Open Access

Gastrointestinal tract cancers: Genetics, heritability and germ line mutations (Review)

  • Authors:
    • Xiao-Peng Lv
  • View Affiliations

  • Published online on: January 20, 2017     https://doi.org/10.3892/ol.2017.5629
  • Pages: 1499-1508
  • Copyright: © Lv . This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastrointestinal (GI) tract cancers that arise due to genetic mutations affect a large number of individuals worldwide. Even though many of the GI tract cancers arise sporadically, few of these GI tract cancers harboring a hereditary predisposition are now recognized and well characterized. These include Cowden syndrome, MUTYH‑associated polyposis, hereditary pancreatic cancer, Lynch syndrome, Peutz-Jeghers syndrome, familial adenomatous polyposis (FAP), attenuated FAP, serrated polyposis syndrome, and hereditary gastric cancer. Molecular characterization of the genes that are involved in these syndromes was useful in the development of genetic testing for diagnosis and also facilitated understanding of the genetic basis of GI cancers. Current knowledge on the genetics of GI cancers with emphasis on heritability and germ line mutations forms the basis of the present review.
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March-2017
Volume 13 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lv X: Gastrointestinal tract cancers: Genetics, heritability and germ line mutations (Review). Oncol Lett 13: 1499-1508, 2017
APA
Lv, X. (2017). Gastrointestinal tract cancers: Genetics, heritability and germ line mutations (Review). Oncology Letters, 13, 1499-1508. https://doi.org/10.3892/ol.2017.5629
MLA
Lv, X."Gastrointestinal tract cancers: Genetics, heritability and germ line mutations (Review)". Oncology Letters 13.3 (2017): 1499-1508.
Chicago
Lv, X."Gastrointestinal tract cancers: Genetics, heritability and germ line mutations (Review)". Oncology Letters 13, no. 3 (2017): 1499-1508. https://doi.org/10.3892/ol.2017.5629