Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma

  • Authors:
    • Jiehao Huang
    • Hongwu Chen
    • Quantang Wei
    • Ziheng Zhang
    • Zhiwei Zhong
    • Yimin Xu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Medical College, Shantou University, Shantou, Guangdong 515041, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1688-1694
    |
    Published online on: January 23, 2017
       https://doi.org/10.3892/ol.2017.5631
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The liver kinase B1 (LKB1)/5'‑adenosine monophosphate‑activated protein kinase pathway has been reported to facilitate glioma cell growth by improving growth conditions. To investigate the clinical significance of LKB1 in human gliomas western blot analysis and quantitative polymerase chain reaction experiments were performed. The present study demonstrated that LKB1 expression was markedly decreased at the messenger RNA and protein levels in 30 freshly prepared glioma tissues, compared with non‑neoplastic brain tissues (P<0.001). Subsequently, immunohistochemical analysis demonstrated that LKB1 immunostaining in 180 glioma tissues was significantly decreased compared with that in the corresponding non‑neoplastic brain tissues (P<0.001). Notably, this downregulation frequently occurred in high‑grade gliomas, and statistical analysis revealed that low LKB1 expression was significantly associated with large tumor size (P=0.02), advanced World Health Organization grade (P=0.006) and low Karnofsky performance scale (P=0.01). The prognostic value of LKB1 expression in patients with glioma was additionally evaluated using Kaplan‑Meier survival curves and Cox proportional hazards regression models. As a result, the overall survival time of patients with glioma with low LKB1 expression was shorter compared with that of patients with high LKB1 expression (P<0.001), and low LKB1 expression also indicated decreased survival time in patients with high‑grade glioma (P<0.001). Collectively, the present data indicated that the downregulation of LKB1 was closely associated with the malignant degree of human gliomas, exhibiting lower expression at a higher grade. Notably, LKB1 may serve as a potential prognostic biomarker for patients with glioma following surgery.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Shapiro WR and Shapiro JR: Biology and treatment of malignant glioma. Oncology (Williston Park). 12:233–240. 1998.PubMed/NCBI

2 

Preusser M, Haberler C and Hainfellner JA: Malignant glioma: Neuropathology and neurobiology. Wien Med Wochenschr. 156:332–337. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Wang B, Li M, Wu Z, Li X, Li Y, Shi X and Cheng W: Associations between SOX2 and miR-200b expression with the clinicopathological characteristics and prognosis of patients with glioma. Exp Ther Med. 10:88–96. 2015.PubMed/NCBI

4 

Wong ML, Kaye AH and Hovens CM: Targeting malignant glioma survival signalling to improve clinical outcomes. J Clin Neurosci. 14:301–308. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Qi J, Yang H, Wang X and Tu Y: The progress in molecular biomarkers of gliomas. Cancer Transl Med. 2:125–129. 2016. View Article : Google Scholar

6 

Rizzo D, Ruggiero A, Martini M, Rizzo V, Maurizi P and Riccardi R: Molecular biology in pediatric high-grade glioma: Impact on prognosis and treatment. Biomed Res Int. 2015:2151352015. View Article : Google Scholar : PubMed/NCBI

7 

Sun R, Li J, Wang B, Guo Y, Ma L, Quan X, Chu Z and Li T: Liver kinase B1 promoter CpG island methylation is related to lung cancer and smoking. Int J Clin Exp Med. 8:14070–14074. 2015.PubMed/NCBI

8 

Rhodes LV, Tate CR, Hoang VT, Burks HE, Gilliam D, Martin EC, Elliott S, Miller DB, Buechlein A, Rusch D, et al: Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1. Oncogenesis. 4:e1682015. View Article : Google Scholar : PubMed/NCBI

9 

Peng DY, Song H and Liu LB: Resveratrol-downregulated phosphorylated liver kinase B1 is involved in senescence of acute myeloid leukemia stem cells. J Huazhong Univ Sci Technolog Med Sci. 35:485–489. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Rao F, Xu J, Fu C, Cha JY, Gadalla MM, Xu R, Barrow JC and Snyder SH: Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1. Proc Natl Acad Sci USA. 112:1773–1778. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Xia C, Ye F, Hu X, Li Z, Jiang B, Fu Y, Cheng X, Shao Z and Zhuang Z: Liver kinase B1 enhances chemoresistance to gemcitabine in breast cancer MDA-MB-231 cells. Oncol Lett. 8:2086–2092. 2014.PubMed/NCBI

12 

Godlewski J, Bronisz A, Nowicki MO, Chiocca EA and Lawler S: microRNA-451: A conditional switch controlling glioma cell proliferation and migration. Cell Cycle. 9:2742–2748. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Jiang YS, Lei JA, Feng F, Liang QM and Wang FR: Probucol suppresses human glioma cell proliferation in vitro via ROS production and LKB1-AMPK activation. Acta Pharmacol Sin. 35:1556–1565. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Vigneswaran K, Neill S and Hadjipanayis CG: Beyond the world health organization grading of infiltrating gliomas: Advances in the molecular genetics of glioma classification. Ann Transl Med. 3:952015.PubMed/NCBI

15 

Ballester M, Castelló A, Ibáñez E, Sánchez A and Folch JM: Real-time quantitative PCR-based system for determining transgene copy number in transgenic animals. Biotechniques. 37:610–613. 2004.PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C (T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Lu J, Sun P, Sun B and Wang C: Low LKB1 expression results in unfavorable prognosis in prostate cancer patients. Med Sci Monit. 21:3722–3727. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Momcilovic M, McMickle R, Abt E, Seki A, Simko SA, Magyar C, Stout DB, Fishbein MC, Walser TC, Dubinett SM and Shackelford DB: Heightening energetic stress selectively targets LKB1-deficient non-small cell lung cancers. Cancer Res. 75:4910–4922. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Gan RY and Li HB: Recent progress on liver kinase B1 (LKB1): Expression, regulation, downstream signaling and cancer suppressive function. Int J Mol Sci. 15:16698–16718. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Momcilovic M and Shackelford DB: Targeting LKB1 in cancer-exposing and exploiting vulnerabilities. Br J Cancer. 113:574–584. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Zhou W, Zhang J and Marcus AI: LKB1 Tumor Suppressor: Therapeutic opportunities knock when LKB1 is inactivated. Genes Dis. 1:64–74. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Monteverde T, Muthalagu N, Port J and Murphy DJ: Evidence of cancer-promoting roles for AMPK and related kinases. FEBS J. 282:4658–4651. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Huang YH, Chen ZK, Huang KT, Li P, He B, Guo X, Zhong JQ, Zhang QY, Shi HQ, Song QT, et al: Decreased expression of LKB1 correlates with poor prognosis in hepatocellular carcinoma patients undergoing hepatectomy. Asian Pac J Cancer Prev. 14:1985–1988. 2013. View Article : Google Scholar : PubMed/NCBI

24 

He TY, Tsai LH, Huang CC, Chou MC and Lee H: LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer. Ann Surg Oncol. 21:(Suppl 4) S703-S710. 2014. View Article : Google Scholar

25 

Yang JY, Jiang SH, Liu DJ, Yang XM, Huo YM, Li J, Hua R, Zhang ZG and Sun YW: Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma. Sci Rep. 5:105752015. View Article : Google Scholar : PubMed/NCBI

26 

Shen Z, Wen XF, Lan F, Shen ZZ and Shao ZM: The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Clin Cancer Res. 8:2085–2090. 2002.PubMed/NCBI

27 

Jiang L, Liang X, Liu M, Wang W, Ma J, Guo Q, Han L, Yang C and Nan K: Reduced expression of liver kinase B1 and Beclin1 is associated with the poor survival of patients with non-small cell lung cancer. Oncol Rep. 32:1931–1958. 2014.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang J, Chen H, Wei Q, Zhang Z, Zhong Z and Xu Y: Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma. Oncol Lett 13: 1688-1694, 2017.
APA
Huang, J., Chen, H., Wei, Q., Zhang, Z., Zhong, Z., & Xu, Y. (2017). Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma. Oncology Letters, 13, 1688-1694. https://doi.org/10.3892/ol.2017.5631
MLA
Huang, J., Chen, H., Wei, Q., Zhang, Z., Zhong, Z., Xu, Y."Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma". Oncology Letters 13.3 (2017): 1688-1694.
Chicago
Huang, J., Chen, H., Wei, Q., Zhang, Z., Zhong, Z., Xu, Y."Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma". Oncology Letters 13, no. 3 (2017): 1688-1694. https://doi.org/10.3892/ol.2017.5631
Copy and paste a formatted citation
x
Spandidos Publications style
Huang J, Chen H, Wei Q, Zhang Z, Zhong Z and Xu Y: Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma. Oncol Lett 13: 1688-1694, 2017.
APA
Huang, J., Chen, H., Wei, Q., Zhang, Z., Zhong, Z., & Xu, Y. (2017). Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma. Oncology Letters, 13, 1688-1694. https://doi.org/10.3892/ol.2017.5631
MLA
Huang, J., Chen, H., Wei, Q., Zhang, Z., Zhong, Z., Xu, Y."Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma". Oncology Letters 13.3 (2017): 1688-1694.
Chicago
Huang, J., Chen, H., Wei, Q., Zhang, Z., Zhong, Z., Xu, Y."Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma". Oncology Letters 13, no. 3 (2017): 1688-1694. https://doi.org/10.3892/ol.2017.5631
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team