Effect of laser therapy on plasma expression of VEGF and bFGF in infants with cutaneous hemangioma

Wang,Fagang; Xu,Rongjian; Xu,Qian; Cao,Yongqian; Lin,Li; Dang,Wei

doi:10.3892/ol.2017.5640

March-2017 Volume 13 Issue 3

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March-2017 Volume 13 Issue 3

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Article

Effect of laser therapy on plasma expression of VEGF and bFGF in infants with cutaneous hemangioma

Authors:
- Fagang Wang
- Rongjian Xu
- Qian Xu
- Yongqian Cao
- Li Lin
- Wei Dang
View Affiliations / Copyright

Affiliations: Department of Aesthetic Plastic and Burn Surgery, Provincial Hospital Afﬁliated to Shandong University, Jinan, Shandong 250021, P.R. China
Pages: 1861-1865
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Published online on: January 25, 2017

https://doi.org/10.3892/ol.2017.5640
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Abstract

The present study aimed to investigate the effect of laser therapy on the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the plasma of infants diagnosed with cutaneous hemangioma, in order to identify biomarkers for assessing the clinical efficacy of laser therapy. In total, 109 infants with superficial abdominal hemangioma received laser treatment, of which 74 were diagnosed in the proliferation phase, 20 in the regression phase and 15 in the involution phase. In addition, 10 infants without cutaneous hemangioma were recruited as normal controls. The concentrations of VEGF and bFGF in peripheral plasma samples were measured using ELISAs. Dynamic changes in the VEGF and bFGF concentrations of 23 infants diagnosed in the proliferation phase were compared before and after laser therapy. The plasma concentration of VEGF in the proliferation phase group was significantly higher compared with that in the regression phase, involution phase and normal control groups (all P<0.01), whereas it did not differ significantly among the regression phase, involution phase and normal control groups (all P>0.05). The plasma concentration of bFGF in the proliferation phase group was significantly higher compared with that in the regression phase, involution phase and normal control groups (all P<0.01), while the bFGF level did not differ significantly among the regression phase, involution phase and normal control groups (all P>0.05). Following laser therapy, the plasma concentrations of VEGF and bFGF in infants with cutaneous hemangioma were significantly decreased (both P<0.01). These results suggested that VEGF and bFGF may serve as reliable indexes to evaluate the clinical efficacy of laser therapy for treating infantile cutaneous hemangioma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of laser therapy on plasma expression of VEGF and bFGF in infants with cutaneous hemangioma

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