Open Access

Mesenchymal stem cell-conditioned medium promotes MDA-MB-231 cell migration and inhibits A549 cell migration by regulating insulin receptor and human epidermal growth factor receptor 3 phosphorylation

  • Authors:
    • Pengfei Li
    • Hongwei Zhou
    • Guohu Di
    • Jin Liu
    • Yang Liu
    • Zhihong Wang
    • Yinxuan Sun
    • Haifeng Duan
    • Junzhong Sun
  • View Affiliations

  • Published online on: January 25, 2017     https://doi.org/10.3892/ol.2017.5641
  • Pages: 1581-1586
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Various in vitro and in vivo studies have linked mesenchymal stem cells (MSCs) with cancer, but little is known about the effect of MSCs on tumor progression. The present study aimed to analyze the role of the MSCs from different tissues, consisting of human bone marrow, adipose and the umbilical cord tissues, and the heterogeneity of tumors in tumor progression. By collecting the culture supernatants of MSCs as MSC‑conditioned media (CMs), the present study found that MSC‑CM produces no significant effect on the proliferation of MDA‑MB‑231 and A549 tumor cells. The migration of MDA‑MB‑231 cells was enhanced upon incubation with MSC‑CM, while that of A549 cells was inhibited. Furthermore, the phosphorylation of insulin receptors (IRs) was upregulated in MSC‑CM‑treated MDA‑MB‑231 cells, while in MSC‑CM‑treated A549 cells, the phosphorylation of human epidermal growth factor receptor 3 (Her3) was downregulated. Taken together, the findings suggest that the phosphorylation of IR and Her3 may contribute to the discrepant effects of MSC‑CM on the migration of the 2 cell lines.
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March-2017
Volume 13 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li P, Zhou H, Di G, Liu J, Liu Y, Wang Z, Sun Y, Duan H and Sun J: Mesenchymal stem cell-conditioned medium promotes MDA-MB-231 cell migration and inhibits A549 cell migration by regulating insulin receptor and human epidermal growth factor receptor 3 phosphorylation. Oncol Lett 13: 1581-1586, 2017
APA
Li, P., Zhou, H., Di, G., Liu, J., Liu, Y., Wang, Z. ... Sun, J. (2017). Mesenchymal stem cell-conditioned medium promotes MDA-MB-231 cell migration and inhibits A549 cell migration by regulating insulin receptor and human epidermal growth factor receptor 3 phosphorylation. Oncology Letters, 13, 1581-1586. https://doi.org/10.3892/ol.2017.5641
MLA
Li, P., Zhou, H., Di, G., Liu, J., Liu, Y., Wang, Z., Sun, Y., Duan, H., Sun, J."Mesenchymal stem cell-conditioned medium promotes MDA-MB-231 cell migration and inhibits A549 cell migration by regulating insulin receptor and human epidermal growth factor receptor 3 phosphorylation". Oncology Letters 13.3 (2017): 1581-1586.
Chicago
Li, P., Zhou, H., Di, G., Liu, J., Liu, Y., Wang, Z., Sun, Y., Duan, H., Sun, J."Mesenchymal stem cell-conditioned medium promotes MDA-MB-231 cell migration and inhibits A549 cell migration by regulating insulin receptor and human epidermal growth factor receptor 3 phosphorylation". Oncology Letters 13, no. 3 (2017): 1581-1586. https://doi.org/10.3892/ol.2017.5641