MicroRNA profile of hepatic epithelioid hemangioendothelioma: A case report

Morishita,Asahiro; Iwama,Hisakazu; Yoneyama,Hirohito; Sakamoto,Teppei; Fujita,Koji; Nomura,Takako; Tani,Joji; Miyoshi,Hisaaki; Fujihara,Shintaro; Nishiyama,Noriko; Kobara,Hideki; Mori,Hirohito; Yamamoto,Naoki; Okano,Keiichi; Suzuki,Yasuyuki; Ibuki,Emi; Haba,Reiji; Himoto,Takashi; Masaki,Tsutomu

doi:10.3892/ol.2017.5643

March-2017 Volume 13 Issue 3

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March-2017 Volume 13 Issue 3

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Case Report Open Access

MicroRNA profile of hepatic epithelioid hemangioendothelioma: A case report

Authors:
- Asahiro Morishita
- Hisakazu Iwama
- Hirohito Yoneyama
- Teppei Sakamoto
- Koji Fujita
- Takako Nomura
- Joji Tani
- Hisaaki Miyoshi
- Shintaro Fujihara
- Noriko Nishiyama
- Hideki Kobara
- Hirohito Mori
- Naoki Yamamoto
- Keiichi Okano
- Yasuyuki Suzuki
- Emi Ibuki
- Reiji Haba
- Takashi Himoto
- Tsutomu Masaki
View Affiliations / Copyright

Affiliations: Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa 761‑0793, Japan, Life Science Research Center, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa 761‑0793, Japan, Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa 761‑0793, Japan, Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa 761‑0793, Japan, Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Takamatsu, Kagawa 761‑0123, Japan

Copyright: © Morishita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1655-1659
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Published online on: January 25, 2017

https://doi.org/10.3892/ol.2017.5643
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Abstract

A 72-year-old female was referred for further evaluation of epigastralgia. Abdominal contrast computed tomography revealed numerous tumors in the two lobes of the liver. Liver biopsy and immunohistochemical staining revealed that the tumor cells were positive for factor VIII‑associated antigen, platelet endothelial cell adhesion molecule 1 and human hematopoietic progenitor cell antigen, concordant with a diagnosis of hepatic epithelioid hemangioendothelioma (HEH). To elucidate the etiology of HEH, particularly the microRNA (miRNA) profiles, tissue samples obtained from normal and tumor tissues were analyzed using a miRNA array system. A total of 14 miRNAs were significantly upregulated and 93 miRNAs were downregulated in the tumor tissues (P<0.01). Additionally, unsupervised hierarchical clustering analysis using Pearson's correlation revealed that the tumor tissues clustered separately from the normal tissues. The miRNA expression profile was analyzed in HEH and compared with angiosarcoma, which exhibits histology similar to HEH. Out of a total of 107 miRNAs, only miR‑122‑5p and miR‑1290 demonstrated a differential expression pattern in angiosarcoma. Therefore, these miRNAs may be novel biological markers for the determination of a diagnosis of HEH in primary mesenchymal tumors of the liver. To the best of our knowledge, this study is the first report of a miRNA microarray analysis in HEH.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

MicroRNA profile of hepatic epithelioid hemangioendothelioma: A case report

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Abstract

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