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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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March-2017 Volume 13 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma

  • Authors:
    • Misako Shibamoto
    • Hidenari Hirata
    • Hidetoshi Eguchi
    • Genta Sawada
    • Noritaka Sakai
    • Yoshiaki Kajiyama
    • Koshi Mimori
  • View Affiliations / Copyright

    Affiliations: Department of Esophageal and Gastroenterological Surgery, Juntendo University School of Medicine, Tokyo 113‑8431, Japan, Department of Surgery, Kyushu University Beppu Hospital, Beppu, Oita 874‑0838, Japan
  • Pages: 1761-1766
    |
    Published online on: January 25, 2017
       https://doi.org/10.3892/ol.2017.5646
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Abstract

Esophageal squamous cell carcinoma (ESCC) has high biological malignant potential among the various digestive tract cancers and is associated with a poor prognosis. To identify novel genes involved in tumor progression, the present study analyzed the genetic and transcriptional alterations in two clinical cohorts, totaling 157 cases of ESCC (78 cases from the discovery set and 79 cases from the validation set). From the discovery set, gene expression and copy number profiles were analyzed using expression arrays and array‑comparative genomic hybridization, respectively. Notably, a copy number loss of caspase‑4 (CASP4) was observed in 82% of ESCC cases and CASP4 expression levels were significantly associated with copy number levels. Gene set enrichment analysis demonstrated that the upregulation of CASP4 expression levels was associated with the signaling pathways involved in apoptosis, inflammatory responses and immune responses. The present study demonstrated that CASP4 expression levels were significantly associated with the expression levels of the endoplasmic reticulum (ER) stress marker glucose‑regulated protein 78, indicating that CASP4 has a role in cell death induced by ER stress in ESCC. In the survival analysis the CASP4 low expression group exhibited a poor prognosis, compared with the CASP4 high expression group in the discovery set (P=0.003); this observation was reproduced in the validation set (P=0.037). Therefore, the results of the current study suggest that CASP4 may function as a tumor-suppressor gene and may have applications as a biomarker for the prediction of the prognosis in ESCC.
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View References

1 

Kuwano H, Nishimura Y, Oyama T, Kato H, Kitagawa Y, Kusano M, Shimada H, Takiuchi H, Toh Y, Doki Y, et al: Guidelines for diagnosis and treatment of carcinoma of the esophagus April 2012 edited by the Japan Esophageal Society. Esophagus. 12:1–30. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Enzinger PC and Mayer RJ: Esophageal cancer. N Engl J Med. 349:2241–2252. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Solomon E, Borrow J and Goddard AD: Chromosome aberrations and cancer. Science. 254:1153–1160. 1991. View Article : Google Scholar : PubMed/NCBI

4 

Yan M, Parker BA, Schwab R and Kurzrock R: HER2 aberrations in cancer: Implications for therapy. Cancer Treat Rev. 40:770–780. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Sawada G, Niida A, Hirata H, Komatsu H, Uchi R, Shimamura T, Takahashi Y, Kurashige J, Matsumura T, Ueo H, et al: An integrative analysis to identify driver genes in esophageal squamous cell carcinoma. PLoS One. 10:e01398082015. View Article : Google Scholar : PubMed/NCBI

6 

Hu N, Wang C, Ng D, Clifford R, Yang HH, Tang ZZ, Wang QH, Han XY, Giffen C, Goldstein AM, et al: Genomic characterization of esophageal squamous cell carcinoma from a high-risk population in China. Cancer Res. 69:5908–5917. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Shi ZZ, Shang L, Jiang YY, Hao JJ, Zhang Y, Zhang TT, Lin DC, Liu SG, Wang BS, Gong T, et al: Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization. Clin Cancer Res. 19:5867–5878. 2013. View Article : Google Scholar : PubMed/NCBI

8 

McIlwain DR, Berger T and Mak TW: Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 5:a0086562013. View Article : Google Scholar : PubMed/NCBI

9 

Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, Imaizumi K, et al: Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol. 165:347–356. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Moorwood C and Barton ER: Caspase-12 ablation preserves muscle function in the mdx mouse. Hum Mol Genet. 23:5325–5341. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Bian ZM, Elner SG and Elner VM: Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 50:6006–6014. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Philchenkov A, Zavelevich M, Kroczak TJ and Los M: Caspases and cancer: Mechanisms of inactivation and new treatment modalities. Exp Oncol. 26:82–97. 2004.PubMed/NCBI

13 

Li H, Wang J, Zeng Z, Fu X and Zhang W: Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in head and cervical undifferentiation squamous cell carcinoma. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 17:739–741. 2003.(In Chinese). PubMed/NCBI

14 

Li H, Zeng ZH, Wang LH and Wang JQ: Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in sinonasal squamous carcinoma. Zhonghua Er Bi Yan Hou Ke Za Zhi. 39:324–327. 2004.(In Chinese). PubMed/NCBI

15 

Soung YH, Jeong EG, Ahn CH, Kim SS, Song SY, Yoo NJ and Lee SH: Mutational analysis of caspase 1, 4, and 5 genes in common human cancers. Hum Pathol. 39:895–900. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES and Mesirov JP: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Moenner M, Pluquet O, Bouchecareilh M and Chevet E: Integrated endoplasmic reticulum stress responses in cancer. Cancer Res. 67:10631–10634. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Kobayashi T, Ogawa M, Sanada T, Mimuro H, Kim M, Ashida H, Akakura R, Yoshida M, Kawalec M, Reichhart JM, et al: The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe. 13:570–583. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shibamoto M, Hirata H, Eguchi H, Sawada G, Sakai N, Kajiyama Y and Mimori K: The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma. Oncol Lett 13: 1761-1766, 2017.
APA
Shibamoto, M., Hirata, H., Eguchi, H., Sawada, G., Sakai, N., Kajiyama, Y., & Mimori, K. (2017). The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma. Oncology Letters, 13, 1761-1766. https://doi.org/10.3892/ol.2017.5646
MLA
Shibamoto, M., Hirata, H., Eguchi, H., Sawada, G., Sakai, N., Kajiyama, Y., Mimori, K."The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma". Oncology Letters 13.3 (2017): 1761-1766.
Chicago
Shibamoto, M., Hirata, H., Eguchi, H., Sawada, G., Sakai, N., Kajiyama, Y., Mimori, K."The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma". Oncology Letters 13, no. 3 (2017): 1761-1766. https://doi.org/10.3892/ol.2017.5646
Copy and paste a formatted citation
x
Spandidos Publications style
Shibamoto M, Hirata H, Eguchi H, Sawada G, Sakai N, Kajiyama Y and Mimori K: The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma. Oncol Lett 13: 1761-1766, 2017.
APA
Shibamoto, M., Hirata, H., Eguchi, H., Sawada, G., Sakai, N., Kajiyama, Y., & Mimori, K. (2017). The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma. Oncology Letters, 13, 1761-1766. https://doi.org/10.3892/ol.2017.5646
MLA
Shibamoto, M., Hirata, H., Eguchi, H., Sawada, G., Sakai, N., Kajiyama, Y., Mimori, K."The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma". Oncology Letters 13.3 (2017): 1761-1766.
Chicago
Shibamoto, M., Hirata, H., Eguchi, H., Sawada, G., Sakai, N., Kajiyama, Y., Mimori, K."The loss of CASP4 expression is associated with poor prognosis in esophageal squamous cell carcinoma". Oncology Letters 13, no. 3 (2017): 1761-1766. https://doi.org/10.3892/ol.2017.5646
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