Anti-apoptotic protein Lifeguard does not act as a tumor marker in breast cancer

Maurer,Viktor; Reimers,Kerstin; Lück,Hans   J.; Vogt,Peter   M.; Bucan,Vesna

doi:10.3892/ol.2017.5658

March-2017 Volume 13 Issue 3

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March-2017 Volume 13 Issue 3

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Anti-apoptotic protein Lifeguard does not act as a tumor marker in breast cancer

Authors:
- Viktor Maurer
- Kerstin Reimers
- Hans J. Lück
- Peter M. Vogt
- Vesna Bucan
View Affiliations / Copyright

Affiliations: Department of Plastic, Hand and Reconstructive Surgery, Hanover Medical School, D‑30652 Hanover, Germany, Gynecologic Oncology Practice, D‑30177 Hanover, Germany

Copyright: © Maurer et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1518-1524
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Published online on: January 27, 2017

https://doi.org/10.3892/ol.2017.5658
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Abstract

The aim of the present study was to use an enzyme-linked immunosorbent assay (ELISA) to determine the concentrations of Lifeguard (LFG) protein in the serum of 36 patients diagnosed with breast cancer and to compare these values with the concentrations of LFG protein in the serum of 7 healthy volunteers in order to detect a possible association between the expression of LFG in the serum and the degree of malignancy of the disease. Although there is no direct association between the LFG protein concentration in the serum and the degree of malignancy of breast cancer, a statistically significant distribution of the concentration in all investigated samples was observed. This indicated an association between the LFG protein concentration in human serum with a currently unknown factor.

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1	Stewart BW and Wild CP: World Cancer Report 2014. IARC Publications; Lyon: 2014
2	Robert Koch Institute and the Association of Population-Based Cancer Registries in Germany, . Cancer in Germany 2009/2010. 9th. Robert Koch Institute; Berlin: 2013, (In German).
3	Malvezzi M, Bertuccio P, Levi F, La Vecchia C and Negri E: European cancer mortality predictions for the year 2014. Ann Oncol. 25:1650–1656. 2014. View Article : Google Scholar : PubMed/NCBI
4	Weinberg RA: The Biology of Cancer. 2nd. Garland Science; New York, NY: pp. 252013
5	Bucan V, Adili MY, Choi CY, Eddy MT, Vogt PM and Reimers K: Transactivation of Lifeguard (LFG) by Akt-/LEF-1 pathway in MCF-7 and MDA-MB 231 human breast cancer cells. Apoptosis. 15:814–821. 2010. View Article : Google Scholar : PubMed/NCBI
6	Bucan V, Choi CY, Lazaridis A, Vogt PM and Reimers K: Silencing of anti-apoptotic transmembrane protein lifeguard sensitizes solid tumor cell lines MCF-7 and SW872 to perifosine-induced cell death activation. Oncol Lett. 2:419–422. 2011.PubMed/NCBI
7	Gratzke AL, Reimers K, Vogt PM and Bucan V: Sensitising breast cancer cells to chemotherapy by downregulation of Lifeguard. Cancer Sci Ther. 6:411–416. 2014.
8	Bucan V, Mandel K, Bertram C, Lazaridis A, Reimers K, Park-Simon TW, Vogt PM and Hass R: LEF-1 regulates proliferation and MMP-7 transcription in breast cancer cells. Genes Cells. 17:559–567. 2012. View Article : Google Scholar : PubMed/NCBI
9	Dastagir N, Lazaridis A, Dastagir K, Reimers K, Vogt PM and Bucan V: Role of lifeguard β-isoform in the development of breast cancer. Oncol Rep. 32:1335–1340. 2014.PubMed/NCBI
10	Wada K, Niida M, Tanaka M and Kamitani T: Ro52-mediated monoubiquitination of IKKβ down-regulates NF-κB Signalling. J Biochem. 146:821–832. 2009. View Article : Google Scholar : PubMed/NCBI
11	Freemont PS: RING for destruction? Curr Biol. 10:R84–R87. 2000. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Anti-apoptotic protein Lifeguard does not act as a tumor marker in breast cancer

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