A novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: A case report Corrigendum in /10.3892/ol.2017.6875

Lee,Jaehyeon; Kim,Dal  Sik; Lee,Hye  Soo; Choi,Sam  Im; Cho,Yong  Gon

doi:10.3892/ol.2017.5668

A novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: A case report

Corrigendum in: /10.3892/ol.2017.6875

Authors:
- Jaehyeon Lee
- Dal Sik Kim
- Hye Soo Lee
- Sam Im Choi
- Yong Gon Cho
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Affiliations: Department of Laboratory Medicine, Chonbuk National University Medical School, Jeonju, Jeollabuk-do 54907, Republic of Korea
Published online on: February 1, 2017 https://doi.org/10.3892/ol.2017.5668
Pages: 1711-1713
Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Variant Philadelphia chromosome translocations involving chromosomes other than 9 and 22 have been reported in 5‑10% of patients with chronic myeloid leukemia (CML). As part of the three‑way variant t(9;22;11) in patients with CML, 11q24 is a novel region that has not previously been investigated. A 22‑year‑old male exhibiting chronic phase CML developed a recurrence of the same phase subsequent to the interruption of imatinib treatment and showed the same chromosomal abnormality, t(9;22;11)(q34;q11.2;q24), that was detected at the initial diagnosis. The recurrent CML responded well to imatinib therapy. These findings suggest that the three‑way variant, t(9;22;11), involving 11q24 may be associated with a good prognosis and response to imatinib. This is the first report of three‑way variant involving 11q24 in a patient with CML.

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