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Article

miR-198 functions as a tumor suppressor in breast cancer by targeting CUB domain-containing protein 1

  • Authors:
    • Yingbin Hu
    • Ziyuan Tang
    • Bonian Jiang
    • Juying Chen
    • Zhongpin Fu
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China
  • Pages: 1753-1760
    |
    Published online on: February 2, 2017
       https://doi.org/10.3892/ol.2017.5673
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Abstract

The molecular mechanisms underlying the dysregulation of microRNAs (miRs) have been previously documented in breast cancer. miR-198 has been reported to be deregulated in several human cancers. However, the detailed effects of miR-198 on breast cancer progression remain unclear. Using quantitative polymerase chain reaction analysis, we demonstrated in the present study that miR‑198 was downregulated in breast cancer tissues and cell lines, and that downregulation of miR‑198 was significantly correlated with lymph node metastasis. Functional studies revealed that miR‑198 inhibited cell proliferation and migration and promoted cell adhesion in aggressive breast cancer cells in vitro. In addition, we observed that CUB domain‑containing protein 1 (CDCP1) was a direct target of miR‑198, and that knockdown of CDCP1 inhibited cell proliferation and migration, and promoted cell adhesion, which was similar to the effects of overexpression of miR‑198. Taken together, we provide evidence to characterize the role of miR‑198/CDCP1 interaction in breast cancer, which may be useful in breast cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Hu Y, Tang Z, Jiang B, Chen J and Fu Z: miR-198 functions as a tumor suppressor in breast cancer by targeting CUB domain-containing protein 1. Oncol Lett 13: 1753-1760, 2017.
APA
Hu, Y., Tang, Z., Jiang, B., Chen, J., & Fu, Z. (2017). miR-198 functions as a tumor suppressor in breast cancer by targeting CUB domain-containing protein 1. Oncology Letters, 13, 1753-1760. https://doi.org/10.3892/ol.2017.5673
MLA
Hu, Y., Tang, Z., Jiang, B., Chen, J., Fu, Z."miR-198 functions as a tumor suppressor in breast cancer by targeting CUB domain-containing protein 1". Oncology Letters 13.3 (2017): 1753-1760.
Chicago
Hu, Y., Tang, Z., Jiang, B., Chen, J., Fu, Z."miR-198 functions as a tumor suppressor in breast cancer by targeting CUB domain-containing protein 1". Oncology Letters 13, no. 3 (2017): 1753-1760. https://doi.org/10.3892/ol.2017.5673
Copy and paste a formatted citation
x
Spandidos Publications style
Hu Y, Tang Z, Jiang B, Chen J and Fu Z: miR-198 functions as a tumor suppressor in breast cancer by targeting CUB domain-containing protein 1. Oncol Lett 13: 1753-1760, 2017.
APA
Hu, Y., Tang, Z., Jiang, B., Chen, J., & Fu, Z. (2017). miR-198 functions as a tumor suppressor in breast cancer by targeting CUB domain-containing protein 1. Oncology Letters, 13, 1753-1760. https://doi.org/10.3892/ol.2017.5673
MLA
Hu, Y., Tang, Z., Jiang, B., Chen, J., Fu, Z."miR-198 functions as a tumor suppressor in breast cancer by targeting CUB domain-containing protein 1". Oncology Letters 13.3 (2017): 1753-1760.
Chicago
Hu, Y., Tang, Z., Jiang, B., Chen, J., Fu, Z."miR-198 functions as a tumor suppressor in breast cancer by targeting CUB domain-containing protein 1". Oncology Letters 13, no. 3 (2017): 1753-1760. https://doi.org/10.3892/ol.2017.5673
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