Astrocyte elevated gene-1 promotes the proliferation and invasion of breast cancer cells by activating the Wnt/β‑catenin signaling pathway

  • Authors:
    • Mengxi Li
    • Yuna Dai
    • Li Wang
    • Lei Li
  • View Affiliations

  • Published online on: February 8, 2017     https://doi.org/10.3892/ol.2017.5695
  • Pages: 2385-2390
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Abstract

Astrocyte elevated gene-1 (AEG1) was identified to be overexpressed in breast cancer, and to be associated with the development of breast cancer. In the present study, AEG1 was identified as highly expressed in the MCF-7, MDA-MB-231 and SK‑BR‑3 breast cancer cell lines and was detected in the MCF‑10A normal breast epithelial cell line. The present study established an AEG1-knockdown MCF-7 cell line to investigate the expression status of certain cancer‑associated proteins. Western blotting demonstrated that AEG1 may affect cancer cell proliferation and invasion via activating the Wnt/β-catenin signaling pathway, a hypothesis that has been supported by cell function tests. The results of the present study demonstrated that when AEG1 was significantly overexpressed in breast cancer cells it promoted cell proliferation and invasion via activating the Wnt/β-catenin signaling pathway. Therefore, AEG1 may serve as a novel therapeutic target in breast cancer.

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April-2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li M, Dai Y, Wang L and Li L: Astrocyte elevated gene-1 promotes the proliferation and invasion of breast cancer cells by activating the Wnt/β‑catenin signaling pathway. Oncol Lett 13: 2385-2390, 2017
APA
Li, M., Dai, Y., Wang, L., & Li, L. (2017). Astrocyte elevated gene-1 promotes the proliferation and invasion of breast cancer cells by activating the Wnt/β‑catenin signaling pathway. Oncology Letters, 13, 2385-2390. https://doi.org/10.3892/ol.2017.5695
MLA
Li, M., Dai, Y., Wang, L., Li, L."Astrocyte elevated gene-1 promotes the proliferation and invasion of breast cancer cells by activating the Wnt/β‑catenin signaling pathway". Oncology Letters 13.4 (2017): 2385-2390.
Chicago
Li, M., Dai, Y., Wang, L., Li, L."Astrocyte elevated gene-1 promotes the proliferation and invasion of breast cancer cells by activating the Wnt/β‑catenin signaling pathway". Oncology Letters 13, no. 4 (2017): 2385-2390. https://doi.org/10.3892/ol.2017.5695