Prevalence of human papillomavirus infection of the anal canal in women: A prospective analysis of high-risk populations

  • Authors:
    • Bernd P. Kost
    • Jörg Hofmann
    • Susanne Stoellnberger
    • Florian Bergauer
    • Thomas Blankenstein
    • Irene Alba‑Alejandre
    • Angela Stein
    • Claudia Stuckart
    • Katharina Weizsäcker
    • Ioannis Mylonas
    • Sven Mahner
    • Andrea Gingelmaier
  • View Affiliations

  • Published online on: February 10, 2017     https://doi.org/10.3892/ol.2017.5714
  • Pages:2495-2501
Metrics: HTML 0 views | PDF 0 views     Cited By (CrossRef): 0 citations

Abstract

Infection with certain types of human papillomavirus (HPV) has been associated with the development of cervical and anal cancer. Worldwide, the incidence of anal cancer has increased markedly. The present study aimed to evaluate the prevalence of HPV infection of the uterine cervix and anal canal in human immunodeficiency virus (HIV)- and non-HIV-infected risk populations. Cervical and anal HPV swabs and cytology samples were collected from 287 patients at the University Hospital of Munich, Germany between 2011 and 2013. Patients were divided into HIV‑negative controls (G1) and two risk groups, including HIV‑negative patients with cytological abnormalities of the cervix (G2) and HIV‑infected patients (G3). Data, including clinical parameters, were analysed. The risk groups had significantly more positive results for HPV in the anus (71.03 and 83.15% for G2 and G3, respectively), as compared with G1. The predominant HPV genotypes found in the anus were high‑risk HPV genotypes, which were significantly correlated with concomittant cervical HPV findings. In the risk groups, a significant association between the cytological findings and HPV detection in the cervix was found, while the results of the anus revealed no significance. The results of the present study suggested that the prevalence of HPV infection in the anal canal of risk populations is high. Furthermore, patients with abnormal cervical cytology results and HIV‑infected women, irrespective of their individual cervical findings, may have a risk of concomittant anal high‑risk HPV infection. Based on the predominant HPV genotypes found in the study, HPV vaccination could reduce the incidence of anal cancer. Nevertheless, high‑risk patients should be intensively screened for anal squamous intraepithelial abnormalities to avoid invasive cancer stages.

Related Articles

Journal Cover

April 2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Kost, B.P., Hofmann, J., Stoellnberger, S., Bergauer, F., Blankenstein, T., Alba‑Alejandre, I. ... Gingelmaier, A. (2017). Prevalence of human papillomavirus infection of the anal canal in women: A prospective analysis of high-risk populations. Oncology Letters, 13, 2495-2501. https://doi.org/10.3892/ol.2017.5714
MLA
Kost, B. P., Hofmann, J., Stoellnberger, S., Bergauer, F., Blankenstein, T., Alba‑Alejandre, I., Stein, A., Stuckart, C., Weizsäcker, K., Mylonas, I., Mahner, S., Gingelmaier, A."Prevalence of human papillomavirus infection of the anal canal in women: A prospective analysis of high-risk populations". Oncology Letters 13.4 (2017): 2495-2501.
Chicago
Kost, B. P., Hofmann, J., Stoellnberger, S., Bergauer, F., Blankenstein, T., Alba‑Alejandre, I., Stein, A., Stuckart, C., Weizsäcker, K., Mylonas, I., Mahner, S., Gingelmaier, A."Prevalence of human papillomavirus infection of the anal canal in women: A prospective analysis of high-risk populations". Oncology Letters 13, no. 4 (2017): 2495-2501. https://doi.org/10.3892/ol.2017.5714