Expression, regulation and function of miR-495 in healthy and tumor tissues (Review)

  • Authors:
    • Hongli Chen
    • Xiaman Wang
    • Ju Bai
    • Aili He
  • View Affiliations

  • Published online on: February 13, 2017     https://doi.org/10.3892/ol.2017.5727
  • Pages: 2021-2026
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Abstract

MicroRNA-495 (miR-495) is a small non-coding RNA encoded by a gene located on chromosome 14 (14q32.31). Its expression is regulated by the transcription factors EF12 and EF47, in addition to promoter methylation status and the fusion oncoprotein mixed-lineage leukemia‑AF9. Previous studies suggest that miR‑495 is involved in various developmental, immunological and inflammatory processes in healthy tissue, and in the proliferation, invasion, metastasis and drug resistance of cancer cells. The role miR‑495 serves in tumors is controversial. miR‑495 primarily functions as a tumor suppressor; however, in a number of cases it acts as an oncogene. miR‑495 has potential applications as a diagnostic and prognostic marker, and as a therapeutic target for genetic and pharmacological manipulation in the treatment of various diseases.

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April 2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Chen, H., Wang, X., Bai, J., & He, A. (2017). Expression, regulation and function of miR-495 in healthy and tumor tissues (Review). Oncology Letters, 13, 2021-2026. https://doi.org/10.3892/ol.2017.5727
MLA
Chen, H., Wang, X., Bai, J., He, A."Expression, regulation and function of miR-495 in healthy and tumor tissues (Review)". Oncology Letters 13.4 (2017): 2021-2026.
Chicago
Chen, H., Wang, X., Bai, J., He, A."Expression, regulation and function of miR-495 in healthy and tumor tissues (Review)". Oncology Letters 13, no. 4 (2017): 2021-2026. https://doi.org/10.3892/ol.2017.5727