Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells

  • Authors:
    • Chaoyou Huang
    • Zheng Han
    • Dehua Wu
  • View Affiliations / Copyright

    Affiliations: Department of Breast and Thyroid Surgery, Hexian Memorial Hospital of Panyu, Guangzhou, Guangdong 511400, P.R. China, Department of Radiotherapy, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1531-1535
    |
    Published online on: May 29, 2017
       https://doi.org/10.3892/ol.2017.6277
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study explored the link between the targeting protein for Xenopus kinesin-like protein 2 (TPX2) gene and breast tumor stem cells in order to screen novel radiosensitizers. Expression of TPX2 protein and gene in breast cancer cells was analyzed by western blot analysis and RT-PCR. Three kinds of broad-spectrum sensitizers were selected and their effects on radiotherapy were analyzed by immunohistochemistry in breast tumor stem cells. TPX2 gene and protein were expressed in breast tumor cells and increased gradually along with the expression of cancer cell differentiation; 25 mg/l lovastatin showed best radio-sensitizing effects on breast cancer cells. Furthermore, immunohistochemical results showed that the positive rate of breast cancer cells processed by 25 mg/l lovastatin were significantly decreased. In conclusion, TPX2 gene is closely related to the development of breast cancer stem cells. Moreover, the sensitizing effects of lovastatin on breast tumor stem cells are the result of its influence on the TPX2 gene.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Sankaranarayanan R and Swaminathan R: Cancer Survival in Africa, Asia, the Caribbean and Central America. 162. IARC Scientific Publications; Lyon: pp. 23–31. 2011

2 

Li Y, Burns JA, Cheney CA, Zhang N, Vitelli S, Wang F, Bett A, Chastain M, Audoly LP and Zhang ZQ: Distinct expression profiles of Notch-1 protein in human solid tumors: implications for development of targeted therapeutic monoclonal antibodies. Biologics. 24:163–171. 2010.

3 

Leong SP, Shen ZZ, Liu TJ, Agarwal G, Tajima T, Paik NS, Sandelin K, Derossis A, Cody H and Foulkes WD: Is breast cancer the same disease in Asian and Western countries? World J Surg. 34:2308–2324. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Matsuda T, Marugame T, Kamo K, Katanoda K, Ajiki W and Sobue T; Japan Cancer Surveillance Research Group, : Cancer incidence and incidence rates in Japan in 2004: based on data from 14 population-based cancer registries in the Monitoring of Cancer Incidence in Japan (MCIJ) Project. Jpn J Clin Oncol. 40:1192–1200. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Matsuda T, Marugame T, Kamo K, Katanoda K, Ajiki W and Sobue T; Japan Cancer Surveillance Research Group, : Cancer incidence and incidence rates in Japan in 2005: based on data from 12 population-based cancer registries in the Monitoring of Cancer Incidence in Japan (MCIJ) project. Jpn J Clin Oncol. 41:139–147. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Zorba A, Buosi V, Kutter S, Kern N, Pontiggia F, Cho YJ and Kern D: Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2. eLife. 3:e026672014. View Article : Google Scholar : PubMed/NCBI

7 

Petry S, Groen AC, Ishihara K, Mitchison TJ and Vale RD: Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell. 152:768–777. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Scholz C and Wagner E: Therapeutic plasmid DNA versus siRNA delivery: common and different tasks for synthetic carriers. J Control Release. 161:554–565. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Silva SM, Moreira HC and Canavarro MC: Examining the links between perceived impact of breast cancer and psychosocial adjustment: the buffering role of posttraumatic growth. Psychooncology. 21:409–418. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Cohen M and Numa M: Posttraumatic growth in breast cancer survivors: a comparison of volunteers and non-volunteers. Psychooncology. 20:69–76. 2011. View Article : Google Scholar : PubMed/NCBI

11 

O'Shaughnessy J, Osborne C, Pippen JE, Yoffe M, Patt D, Rocha C, Koo IC, Sherman BM and Bradley C: Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med. 36:205–214. 2011. View Article : Google Scholar

12 

Shimura T, Takenaka Y, Fukumori T, Tsutsumi S, Okada K, Hogan V, Kikuchi A, Kuwano H and Raz A: Implication of galectin-3 in Wnt signaling. Cancer Res. 65:3535–3537. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Gürtler A, Kunz N, Gomolka M, Hornhardt S, Friedl AA, McDonald K, Kohn JE and Posch A: Stain-Free technology as a normalization tool in Western blot analysis. Anal Biochem. 433:105–111. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Elbers A, Meiswinkel R, van Weezep E, van Oldruitenborgh-Oosterbaan M Sloet and Kooi B: Schmallenberg virus detected by RT-PCR in Culicoides biting midges captured during the 2011 epidemic in the Netherlands. Emerg Infect Diseases. 433:105–111. 2013.

15 

Vollebergh MA, Jonkers J and Linn SC: Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers. Cell Mol Life Sci. 69:223–245. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, Friedlander M, Arun B, Loman N, Schmutzler RK, et al: Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet. 376:235–244. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Blanco I, Kuchenbaecker K, Cuadras D, Wang X, Barrowdale D, de Garibay GR, Librado P, Sánchez-Gracia A, Rozas J, Bonifaci N, et al: Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers. PLoS One. 10:e1200202016.

18 

Neumayer G, Belzil C, Gruss OJ and Nguyen MD: TPX2: of spindle assembly, DNA damage response, and cancer. Cell Mol Life Sci. 71:3027–3047. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Hsu HT, Dodd MJ, Guo SE, Lee KA, Hwang SL and Lai YH: Predictors of exercise frequency in breast cancer survivors in Taiwan. J Clin Nurs. 20:1923–1935. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Newlaczyl AU and Yu LG: Galectin-3 - a jack-of-all-trades in cancer. Cancer Lett. 313:123–128. 2011. View Article : Google Scholar : PubMed/NCBI

21 

McGuire R, Waltman N and Zimmerman L: Intervention components promoting adherence to strength training exercise in breast cancer survivors with bone loss. West J Nurs Res. 33:671–689. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang C, Han Z and Wu D: Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells. Oncol Lett 14: 1531-1535, 2017.
APA
Huang, C., Han, Z., & Wu, D. (2017). Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells. Oncology Letters, 14, 1531-1535. https://doi.org/10.3892/ol.2017.6277
MLA
Huang, C., Han, Z., Wu, D."Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells". Oncology Letters 14.2 (2017): 1531-1535.
Chicago
Huang, C., Han, Z., Wu, D."Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells". Oncology Letters 14, no. 2 (2017): 1531-1535. https://doi.org/10.3892/ol.2017.6277
Copy and paste a formatted citation
x
Spandidos Publications style
Huang C, Han Z and Wu D: Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells. Oncol Lett 14: 1531-1535, 2017.
APA
Huang, C., Han, Z., & Wu, D. (2017). Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells. Oncology Letters, 14, 1531-1535. https://doi.org/10.3892/ol.2017.6277
MLA
Huang, C., Han, Z., Wu, D."Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells". Oncology Letters 14.2 (2017): 1531-1535.
Chicago
Huang, C., Han, Z., Wu, D."Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells". Oncology Letters 14, no. 2 (2017): 1531-1535. https://doi.org/10.3892/ol.2017.6277
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team