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Article

Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S‑1 adjuvant chemotherapy

  • Authors:
    • Yoshinori Fujiwara
    • Shuichi Fukuda
    • Masanori Tsujie
    • Kotaro Kitani
    • Keisuke Inoue
    • Tomonori Hayashi
    • Hajime Ishikawa
    • Masao Yukawa
    • Masatoshi Inoue
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Surgery, Nara Hospital, Kindai University School of Medicine, Ikoma, Nara 630‑0293, Japan, Department of Pharmacy, Nara Hospital, Kindai University School of Medicine, Ikoma, Nara 630‑0293, Japan
  • Pages: 1621-1627
    |
    Published online on: May 31, 2017
       https://doi.org/10.3892/ol.2017.6286
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Abstract

Predictors of survival in patients with stage II/III gastric cancer (GC) who received tegafur/gimeracil/oteracil (S‑1) adjuvant chemotherapy (ACT) subsequent to gastrectomy were examined. Additionally, the association between dose intensity of S‑1 and survival rate was investigated. A total of 62 patients with stage II/III gastric cancer were retrospectively evaluated, each of whom had received a curative D2 gastrectomy and S‑1 ACT. The relative performance (RP; administered/planned S‑1 doses x100%), body mass index (BMI), prognostic nutritional index (PNI) and body weight (BW) were calculated, and the association of survival with these factors and other clinicopathological parameters was examined. The 1‑year treatment continuation rate for S‑1 was 94.2%, excluding patients who experienced cancer recurrences during their ACT year. The initial S‑1 reduction rate was 38.7%. Patients with stage II/IIIA disease exhibited significantly improved 5‑year overall survival rates compared with patients with stage IIIB GC, 81.6/73.7 vs. 33.8% (P<0.01). No association between RP and survival was observed. BMI, BW and PNI were significantly decreased following surgery compared with preoperative states. In the univariate analysis, postoperative BW loss (BMI loss), pathological stage and >7 lymph node metastases were significantly associated with outcome (P<0.05); in the multivariate analysis, postoperative BW loss >10.6% and pathological stages were independent prognostic factors for survival. Continuing S‑1 ACT for the full year exhibited a greater effect on survival compared with dosage. Early postoperative nutritional deterioration may decrease the survival rates in these patients.
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Copy and paste a formatted citation
Spandidos Publications style
Fujiwara Y, Fukuda S, Tsujie M, Kitani K, Inoue K, Hayashi T, Ishikawa H, Yukawa M and Inoue M: Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S‑1 adjuvant chemotherapy. Oncol Lett 14: 1621-1627, 2017.
APA
Fujiwara, Y., Fukuda, S., Tsujie, M., Kitani, K., Inoue, K., Hayashi, T. ... Inoue, M. (2017). Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S‑1 adjuvant chemotherapy. Oncology Letters, 14, 1621-1627. https://doi.org/10.3892/ol.2017.6286
MLA
Fujiwara, Y., Fukuda, S., Tsujie, M., Kitani, K., Inoue, K., Hayashi, T., Ishikawa, H., Yukawa, M., Inoue, M."Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S‑1 adjuvant chemotherapy". Oncology Letters 14.2 (2017): 1621-1627.
Chicago
Fujiwara, Y., Fukuda, S., Tsujie, M., Kitani, K., Inoue, K., Hayashi, T., Ishikawa, H., Yukawa, M., Inoue, M."Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S‑1 adjuvant chemotherapy". Oncology Letters 14, no. 2 (2017): 1621-1627. https://doi.org/10.3892/ol.2017.6286
Copy and paste a formatted citation
x
Spandidos Publications style
Fujiwara Y, Fukuda S, Tsujie M, Kitani K, Inoue K, Hayashi T, Ishikawa H, Yukawa M and Inoue M: Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S‑1 adjuvant chemotherapy. Oncol Lett 14: 1621-1627, 2017.
APA
Fujiwara, Y., Fukuda, S., Tsujie, M., Kitani, K., Inoue, K., Hayashi, T. ... Inoue, M. (2017). Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S‑1 adjuvant chemotherapy. Oncology Letters, 14, 1621-1627. https://doi.org/10.3892/ol.2017.6286
MLA
Fujiwara, Y., Fukuda, S., Tsujie, M., Kitani, K., Inoue, K., Hayashi, T., Ishikawa, H., Yukawa, M., Inoue, M."Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S‑1 adjuvant chemotherapy". Oncology Letters 14.2 (2017): 1621-1627.
Chicago
Fujiwara, Y., Fukuda, S., Tsujie, M., Kitani, K., Inoue, K., Hayashi, T., Ishikawa, H., Yukawa, M., Inoue, M."Outcome predictors for patients with stage II/III gastric cancer who undergo gastrectomy and S‑1 adjuvant chemotherapy". Oncology Letters 14, no. 2 (2017): 1621-1627. https://doi.org/10.3892/ol.2017.6286
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