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Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males

  • Authors:
    • Xuyang Xiao
    • Wubin He
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China, Biological Therapy Center Laboratory, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1588-1594
    |
    Published online on: June 1, 2017
       https://doi.org/10.3892/ol.2017.6289
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Abstract

The objective of the present study was to analyze the relationship between genetic polymorphisms of the rs2736098 locus of the telomerase reverse transcriptase (TERT) gene and the rs401681 locus of the cleft lip and palate transmembrane protein 1 (CLPTM1L) gene and the risk of developing lung cancer in males in Jinzhou. A total of 214 lung cancer patients who were admitted in Jinzhou Medical University were analyzed, and 216 healthy males were selected as controls. Venous blood from all subjects and data on relevant risk factors were collected. DNA was extracted from peripheral blood by the phenol-chloroform method. Real-time fluorescent quantitative PCR (TaqMan real‑time PCR) was used for DNA amplification. The genotyping results of the genetic polymorphisms of the TERT rs2736098 and CLPTM1L rs401681 loci were detected. The risk of developing lung cancer in the population with the TERT rs2736098 locus carrying the T allele was 1.614 times that with the TERT rs2736098 locus carrying the C allele after adjustment of the age factor. The risk of developing lung cancer in the population carrying the TT mutant genotype and the CT genotype increased significantly compared with that carrying the CC wild genotype [odds ratio (OR)=1.815, 95% CI=1.132-2.957; OR=2.417, 95% CI=1.158‑4.943]. Based on a comparison between the combination of the two mutant genotypes (CT+TT) and the wild homozygous genotype (CC), the mutant genotype increased the risk of developing lung cancer (OR=1.955, 95% CI=1.213-3.157). The risk of developing lung cancer in the population with the CLPTM1L rs401681 locus carrying the T allele was 1.399 times that carrying the C allele (OR=1.343, 95% CI=1.035-1.978). The population with the TERT rs2736098 locus carrying the mutant genotype (CT+TT) was associated with the number of tumors (OR=0.553, 95% CI=0.236-0.928). In conclusion, in males, the TERT rs2736098 and CLPTM1L rs401681 T alleles are the susceptibility factors for developing lung cancer. Individuals, including the smoking population, who carry both the TERT rs2736098 and CLPTM1L rs401681 T alleles are more likely to develop lung cancer.
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1 

Yin J, Li Y, Yin M, Sun J, Liu L, Qin Q, Li X, Long L, Nie S and Wei S: TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publications. PLoS One. 7:e506502012. View Article : Google Scholar : PubMed/NCBI

2 

Mocellin S, Verdi D, Pooley KA, Landi MT, Egan KM, Baird DM, Prescott J, De Vivo I and Nitti D: Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis. J Natl Cancer Inst. 104:840–854. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Chen XF, Cai S, Chen QG, Ni ZH, Tang JH, Xu DW and Wang XB: Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma. Genet Mol Res. 11:370–378. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Jiang M, Wu H and Qin C: Genetic variant rs401681 at 5p15.33 modifies susceptibility to lung cancer but not esophageal squamous cell carcinoma. PLoS One. 8:e842772013. View Article : Google Scholar : PubMed/NCBI

5 

Yang IA, Holloway JW and Fong KM: Genetic susceptibility to lung cancer and co-morbidities. J Thorac Dis. 5 Suppl 5:454–462. 2013.

6 

Zhong R, Liu L, Zou L, Zhu Y, Chen W, Zhu B, Shen N, Rui R, Long L, Ke J, et al: Genetic variations in TERT-CLPTM1L locus are associated with risk of lung cancer in Chinese population. Mol Carcinog. 52 Suppl 1:E118–E126. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Li C, Yin Z, Wu W, Li X, Ren Y and Zhou B: Genetic variations in TERT-CLPTM1L genes and risk of lung cancer in Chinese women nonsmokers. PLoS One. 8:e649882013. View Article : Google Scholar : PubMed/NCBI

8 

Lan Q, Cawthon R, Gao Y, Hu W, Hosgood HD III, Barone-Adesi F, Ji BT, Bassig B, Chow WH, Shu X, et al: Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. PLoS One. 8:e592302013. View Article : Google Scholar : PubMed/NCBI

9 

Myneni AA, Chang SC, Niu R, Liu L, Ochs-Balcom HM, Li Y, Zhang C, Zhao B, Shi J, Han X, et al: Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer - a case-control study in a Chinese population. Lung Cancer. 80:131–137. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Zhao Z, Li C, Yang L, Zhang X, Zhao X, Song X, Li X, Wang J, Qian J, Yang Y, et al: Significant association of 5p15.33 (TERT-CLPTM1L genes) with lung cancer in Chinese Han population. Exp Lung Res. 39:91–98. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Wang H, Zhao Y, Ma J, Zhang G, Mu Y, Qi G, Fang Z, Wang L, Fan Q and Ma Z: The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population. Genet Mol Res. 12:67–73. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Tseng TS, Park JY, Zabaleta J, Moody-Thomas S, Sothern MS, Chen T, Evans DE and Lin HY: Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma. PLoS One. 9:e1072682014. View Article : Google Scholar : PubMed/NCBI

13 

Yin Z, Cui Z, Ren Y, Zhang H, Yan Y, Zhao Y, Ma R, Wang Q, He Q and Zhou B: Genetic polymorphisms of TERT and CLPTM1L, cooking oil fume exposure, and risk of lung cancer: a case-control study in a Chinese non-smoking female population. Med Oncol. 31:1142014. View Article : Google Scholar : PubMed/NCBI

14 

Wang Z, Zhu B, Zhang M, Parikh H, Jia J, Chung CC, Sampson JN, Hoskins JW, Hutchinson A, Burdette L, et al: Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet. 23:6616–6633. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Zhang Y, Zhao M, Shen L, Ren Y, Su L, Li X, Yin Z and Zhou B: Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer: a case-control study in northeast Chinese male population. Med Oncol. 31:182014. View Article : Google Scholar : PubMed/NCBI

16 

Zhao MM, Zhang Y, Shen L, Ren YW, Li XL, Yin ZH and Zhou BS: Genetic variations in TERT-CLPTM1L genes and risk of lung cancer in a Chinese population. Asian Pac J Cancer Prev. 15:2809–2813. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Azad AK, Qiu X, Boyd K, Kuang Q, Emami M, Perera N, Palepu P, Patel D, Chen Z, Cheng D, et al: A genetic sequence variant (GSV) at susceptibility loci of 5p15.33 (TERT-CLPTM1L) is associated with survival outcome in locally advanced and metastatic non-small-cell lung cancer (NSCLC). Lung Cancer. 84:289–294. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Wu H and Zhu R: Quantitative assessment of common genetic variants on chromosome 5p15 and lung cancer risk. Tumour Biol. 35:6055–6063. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Zhang C, Doherty JA, Burgess S, Hung RJ, Lindström S, Kraft P, Gong J, Amos CI, Sellers TA, Monteiro AN, et al: GECCO and GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL: Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study. Hum Mol Genet. 24:5356–5366. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Liu SG, Ma L, Cen QH, Huang JS, Zhang JX and Zhang JJ: Association of genetic polymorphisms in TERT-CLPTM1L with lung cancer in a Chinese population. Genet Mol Res. 14:4469–4476. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Rennert G, Kremer R, Rennert HS, Wollner M, Agbarya A, Pinchev M, Lejbkowicz F, Spitz MR and Muscat JE: Lower lung cancer rates in Jewish smokers in Israel and the USA. Int J Cancer. 137:2155–2162. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Kocarnik JM, Park SL, Han J, Dumitrescu L, Cheng I, Wilkens LR, Schumacher FR, Kolonel L, Carlson CS, Crawford DC, et al: Pleiotropic and sex-specific effects of cancer GWAS SNPs on melanoma risk in the population architecture using genomics and epidemiology (PAGE) study. PLoS One. 10:e01204912015. View Article : Google Scholar : PubMed/NCBI

23 

Kachuri L, Latifovic L, Liu G and Hung RJ: Systematic review of genetic variation in chromosome 5p15.33 and telomere length as predictive and prognostic biomarkers for lung cancer. Cancer Epidemiol Biomarkers Prev. 25:1537–1549. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Karami S, Han Y, Pande M, Cheng I, Rudd J, Pierce BL, Nutter EL, Schumacher FR, Kote-Jarai Z, Lindstrom S, et al: GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL: Telomere structure and maintenance gene variants and risk of five cancer types. Int J Cancer. 139:2655–2670. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiao X and He W: Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males. Oncol Lett 14: 1588-1594, 2017.
APA
Xiao, X., & He, W. (2017). Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males. Oncology Letters, 14, 1588-1594. https://doi.org/10.3892/ol.2017.6289
MLA
Xiao, X., He, W."Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males". Oncology Letters 14.2 (2017): 1588-1594.
Chicago
Xiao, X., He, W."Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males". Oncology Letters 14, no. 2 (2017): 1588-1594. https://doi.org/10.3892/ol.2017.6289
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao X and He W: Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males. Oncol Lett 14: 1588-1594, 2017.
APA
Xiao, X., & He, W. (2017). Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males. Oncology Letters, 14, 1588-1594. https://doi.org/10.3892/ol.2017.6289
MLA
Xiao, X., He, W."Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males". Oncology Letters 14.2 (2017): 1588-1594.
Chicago
Xiao, X., He, W."Genetic polymorphisms in the TERT-CLPTM1L region and lung cancer susceptibility in Chinese males". Oncology Letters 14, no. 2 (2017): 1588-1594. https://doi.org/10.3892/ol.2017.6289
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