Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing
advanced gastric neuroendocrine carcinoma

Tsuruta,Nobuhiro; Takayoshi,Kotoe; Arita,Shuji; Aikawa,Tomomi; Ariyama,Hiroshi; Kusaba,Hitoshi; Ohuchida,Kenoki; Nagai,Eishi; Kohashi,Kenichi; Hirahashi,Minako; Inadomi,Kyoko; Tanaka,Mamoru; Sagara,Kosuke; Okumura,Yuta; Nio,Kenta; Nakano,Michitaka; Nakamura,Masafumi; Oda,Yoshinao; Akashi,Koichi; Baba,Eishi

doi:10.3892/ol.2017.6299

Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing advanced gastric neuroendocrine carcinoma

Authors:
- Nobuhiro Tsuruta
- Kotoe Takayoshi
- Shuji Arita
- Tomomi Aikawa
- Hiroshi Ariyama
- Hitoshi Kusaba
- Kenoki Ohuchida
- Eishi Nagai
- Kenichi Kohashi
- Minako Hirahashi
- Kyoko Inadomi
- Mamoru Tanaka
- Kosuke Sagara
- Yuta Okumura
- Kenta Nio
- Michitaka Nakano
- Masafumi Nakamura
- Yoshinao Oda
- Koichi Akashi
- Eishi Baba
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Affiliations: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812‑8582, Japan, Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan, Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan, Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan
Published online on: June 2, 2017 https://doi.org/10.3892/ol.2017.6299
Pages: 1500-1504
Copyright: © Tsuruta et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

An advanced granulocyte-colony stimulating factor (G-CSF)-producing tumor is rare, and it exhibits leukocytosis in association with high serum G‑CSF levels. A 67‑year‑old male with a 1‑month history of bloody emesis and black stools was revealed to exhibit leukocytosis, anemia and a high serum concentration of G‑CSF. During a gastrointestinal endoscopy, an ulcerating tumor was identified in the stomach. Computed tomography and a fluorodeoxyglucose‑positron emission tomography scan demonstrated direct invasion of the gastric tumor into the transverse colon, regional lymphadenopathy, lung nodules and diffuse high uptake of FDG in bone marrow. The histological diagnosis was a G-CSF-producing neuroendocrine carcinoma (NEC) (tumor 4b, node 2, metastasis 1, pulmonary, clinical stage IV). Systemic chemotherapy consisting of cisplatin and irinotecan was started. Common terminology criteria of adverse events grade 3 tumor lysis syndrome and gastric penetration appeared. Grade 4 neutropenia lasted for 10 days despite intensive G‑CSF administration. Prominent shrinkage of the primary and the metastatic tumors was observed subsequent to 3 cycles of chemotherapy. Total gastrectomy and resection of the transverse colon were subsequently performed. Systemic chemotherapy was effective for a G-CSF-producing advanced gastric NEC with careful monitoring and appropriate supportive care for severe adverse events.

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1	Demetri GD and Griffin JD: Granulocyte colony-stimulating factor and its receptor. Blood. 78:2791–2808. 1991.PubMed/NCBI
2	Kojima K, Nakashima F, Boku A, Muroishi Y, Nakanishi I and Oda Y: Clinicopathological study of involvement of granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor in non-lymphohematopoietic malignant tumors accompanied by leukocytosis. Histol Histopathol. 17:1005–1016. 2002.PubMed/NCBI
3	Kawaguchi M, Asada Y, Terada T, Takehara A, Munemoto Y, Fujisawa K, Mitsui T, Iida Y, Miura S and Sudo Y: Aggressive recurrence of gastric cancer as a granulocyte-colony stimulating factor-producing tumor. Int J Clin Oncol. 15:191–195. 2010. View Article : Google Scholar : PubMed/NCBI
4	Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A and Evans DB: One hundred years after ‘carcinoid’: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 26:3063–3072. 2008. View Article : Google Scholar : PubMed/NCBI
5	Bosman FT, Cameiro F, Hruban RH and Theise ND: WHO classification of tumors of the digestive system. 4th. WHO Press; Geneva: pp. 13–14. 2010
6	Wong YN, Jack RH, Mak V, Henrik M and Davies EA: The epidemiology and survival of extrapulmonary small cell carcinoma in South East England, 1970–2004. BMC Cancer. 9:2092009. View Article : Google Scholar : PubMed/NCBI
7	Kulke MH, Shah MH, Benson AB III, Bergsland E, Berlin JD, Blaszkowsky LS, Emerson L, Engstrom PF, Fanta P, Giordano T, et al: Neuroendocrine tumors, version 1.2015. J Natl Compr Canc Netw. 13:78–108. 2015. View Article : Google Scholar : PubMed/NCBI
8	Yamaguchi T, Machida N, Morizane C, Kasuga A, Takahashi H, Sudo K, Nishina T, Tobimatsu K, Ishido K, Furuse J, et al: Multicenter retrospective analysis of systemic chemotherapy for advanced neuroendocrine carcinoma of the digestive system. Cancer Sci. 105:1176–1181. 2014. View Article : Google Scholar : PubMed/NCBI
9	Sato Y, Takahashi Y, Nishiie K, Okubo S, Fujikaw K, Shintani N, Takada K, Sato Y, Takimoto R, Kato J and Niitsu Y: A case of granulocyte-colony stimulating factor producing small cell carcinoma of esophagus. Nihon Shokakibyo Gakkai Zasshi. 102:888–893. 2005.(In Japanese). PubMed/NCBI
10	Watanabe A, Wachi T, Omi H, Nishii H, Ochiai K, Tanaka T and Endo Y: Granulocyte colony-stimulating factor-producing small-cell carcinoma of the uterine cervix: Report of a case. Diaqn Cytopathol. 23:269–274. 2000. View Article : Google Scholar
11	Noda K, Nishiwaki Y, Kawahara M, Negoro S, Sugiura T, Yokoyama A, Fukuoka M, Mori K, Watanabe K, Tamura T, et al: Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med. 346:85–91. 2002. View Article : Google Scholar : PubMed/NCBI
12	Asano S, Urabe A, Okabe T, Sato N and Kondo Y: Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood. 49:845–852. 1977.PubMed/NCBI
13	Tsuyuoka R, Takahashi T, Sasaki Y, Taniguchi Y, Fukumoto M, Suzuki A, Nakamura K, Kobayashi S, Kudo T and Nakao K: Colony-stimulating factor-producing tumours: Production of granulocyte colony-stimulating factor and interleukin-6 is secondary to interleukin-1 production. Eur J Cancer. 30A:2130–2136. 1994. View Article : Google Scholar : PubMed/NCBI
14	Matsumoto M, Nakayama T, Inoue D, Takamatsu K, Itotani R, Ishitoko M, Suzuki S, Sakuramoto M, Yuba Y, Yoshie O, et al: A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. BMC Cancer. 14:5882014. View Article : Google Scholar : PubMed/NCBI
15	Morales-Arias J, Meyers PA, Bolontrade MF, Rodriguez N, Zhou Z, Reddy K, Chou AJ, Koshkina NV and Kleinerman ES: Expression of granulocyte-colony-stimulating factor and its receptor in human Ewing sarcoma cells and patient tumor specimens: Potential consequences of granulocyte-colony-stimulating factor administration. Cancer. 110:1568–1577. 2007. View Article : Google Scholar : PubMed/NCBI
16	Moertel CG, Kvols LK, O'Connell MJ and Rubin J: Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin. Evidence of major therapeutic activity in the anaplastic variants of these neoplasms. Cancer. 68:227–232. 1991. View Article : Google Scholar : PubMed/NCBI
17	Teramachi M, Miyamoto N, Yamamoto Y, Sasaka T, Nakamura T and Kitamura F: A case of large cell carcinoma of the lung which is suspected of producing granulocyte colony-stimulating factor. Nihon Kyobu Shikkan Gakkai Zasshi. 30:1327–1332. 1992.(In Japanese). PubMed/NCBI
18	Hasegawa S, Suda T, Negi K and Hattori Y: Lung large cell carcinoma producing granulocyte-colony-stimulating factor. Ann Thorac Surg. 83:308–310. 2007. View Article : Google Scholar : PubMed/NCBI
19	Gemici C: Tumor lysis syndrome in solid tumors. Clin Oncol (R Coll Radiol). 18:773–780. 2006. View Article : Google Scholar : PubMed/NCBI
20	Amadori S, Suciu S, Jehn U, Stasi R, Thomas X, Marie JP, Muus P, Lefrère F, Berneman Z, Fillet G, et al: Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia: Final results of AML-13, A randomized phase-3 study. Blood. 106:27–34. 2005. View Article : Google Scholar : PubMed/NCBI
21	Burris HA, Belani CP, Kaufman PA, Gordon AN, Schwartzberg LS, Paroly WS, Shahin S, Dreiling L and Saven A: Pegfilgrastim on the same day versus next day of chemotherapy in patients with breast cancer, non-small-cell lung cancer, ovarian cancer, and non-hodgkin's lymphoma: Results of four multicenter, double-blind, randomized phase ii studies. J Oncol Pract. 6:133–140. 2010. View Article : Google Scholar : PubMed/NCBI
22	Yoshida K, Yamaguchi K, Okumura N, Tanahashi T and Kodera Y: Is conversion therapy possible in stage IV gastric cancer: The proposal of new biological categories of classification. Gastric Cancer. 19:329–338. 2016. View Article : Google Scholar : PubMed/NCBI