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Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing advanced gastric neuroendocrine carcinoma

  • Authors:
    • Nobuhiro Tsuruta
    • Kotoe Takayoshi
    • Shuji Arita
    • Tomomi Aikawa
    • Hiroshi Ariyama
    • Hitoshi Kusaba
    • Kenoki Ohuchida
    • Eishi Nagai
    • Kenichi Kohashi
    • Minako Hirahashi
    • Kyoko Inadomi
    • Mamoru Tanaka
    • Kosuke Sagara
    • Yuta Okumura
    • Kenta Nio
    • Michitaka Nakano
    • Masafumi Nakamura
    • Yoshinao Oda
    • Koichi Akashi
    • Eishi Baba
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Kyushu University Hospital, Fukuoka 812‑8582, Japan, Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan, Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan, Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan
    Copyright: © Tsuruta et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1500-1504
    |
    Published online on: June 2, 2017
       https://doi.org/10.3892/ol.2017.6299
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Abstract

An advanced granulocyte-colony stimulating factor (G-CSF)-producing tumor is rare, and it exhibits leukocytosis in association with high serum G‑CSF levels. A 67‑year‑old male with a 1‑month history of bloody emesis and black stools was revealed to exhibit leukocytosis, anemia and a high serum concentration of G‑CSF. During a gastrointestinal endoscopy, an ulcerating tumor was identified in the stomach. Computed tomography and a fluorodeoxyglucose‑positron emission tomography scan demonstrated direct invasion of the gastric tumor into the transverse colon, regional lymphadenopathy, lung nodules and diffuse high uptake of FDG in bone marrow. The histological diagnosis was a G-CSF-producing neuroendocrine carcinoma (NEC) (tumor 4b, node 2, metastasis 1, pulmonary, clinical stage IV). Systemic chemotherapy consisting of cisplatin and irinotecan was started. Common terminology criteria of adverse events grade 3 tumor lysis syndrome and gastric penetration appeared. Grade 4 neutropenia lasted for 10 days despite intensive G‑CSF administration. Prominent shrinkage of the primary and the metastatic tumors was observed subsequent to 3 cycles of chemotherapy. Total gastrectomy and resection of the transverse colon were subsequently performed. Systemic chemotherapy was effective for a G-CSF-producing advanced gastric NEC with careful monitoring and appropriate supportive care for severe adverse events.
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Copy and paste a formatted citation
Spandidos Publications style
Tsuruta N, Takayoshi K, Arita S, Aikawa T, Ariyama H, Kusaba H, Ohuchida K, Nagai E, Kohashi K, Hirahashi M, Hirahashi M, et al: Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing advanced gastric neuroendocrine carcinoma. Oncol Lett 14: 1500-1504, 2017.
APA
Tsuruta, N., Takayoshi, K., Arita, S., Aikawa, T., Ariyama, H., Kusaba, H. ... Baba, E. (2017). Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing advanced gastric neuroendocrine carcinoma. Oncology Letters, 14, 1500-1504. https://doi.org/10.3892/ol.2017.6299
MLA
Tsuruta, N., Takayoshi, K., Arita, S., Aikawa, T., Ariyama, H., Kusaba, H., Ohuchida, K., Nagai, E., Kohashi, K., Hirahashi, M., Inadomi, K., Tanaka, M., Sagara, K., Okumura, Y., Nio, K., Nakano, M., Nakamura, M., Oda, Y., Akashi, K., Baba, E."Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing advanced gastric neuroendocrine carcinoma". Oncology Letters 14.2 (2017): 1500-1504.
Chicago
Tsuruta, N., Takayoshi, K., Arita, S., Aikawa, T., Ariyama, H., Kusaba, H., Ohuchida, K., Nagai, E., Kohashi, K., Hirahashi, M., Inadomi, K., Tanaka, M., Sagara, K., Okumura, Y., Nio, K., Nakano, M., Nakamura, M., Oda, Y., Akashi, K., Baba, E."Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing advanced gastric neuroendocrine carcinoma". Oncology Letters 14, no. 2 (2017): 1500-1504. https://doi.org/10.3892/ol.2017.6299
Copy and paste a formatted citation
x
Spandidos Publications style
Tsuruta N, Takayoshi K, Arita S, Aikawa T, Ariyama H, Kusaba H, Ohuchida K, Nagai E, Kohashi K, Hirahashi M, Hirahashi M, et al: Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing advanced gastric neuroendocrine carcinoma. Oncol Lett 14: 1500-1504, 2017.
APA
Tsuruta, N., Takayoshi, K., Arita, S., Aikawa, T., Ariyama, H., Kusaba, H. ... Baba, E. (2017). Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing advanced gastric neuroendocrine carcinoma. Oncology Letters, 14, 1500-1504. https://doi.org/10.3892/ol.2017.6299
MLA
Tsuruta, N., Takayoshi, K., Arita, S., Aikawa, T., Ariyama, H., Kusaba, H., Ohuchida, K., Nagai, E., Kohashi, K., Hirahashi, M., Inadomi, K., Tanaka, M., Sagara, K., Okumura, Y., Nio, K., Nakano, M., Nakamura, M., Oda, Y., Akashi, K., Baba, E."Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing advanced gastric neuroendocrine carcinoma". Oncology Letters 14.2 (2017): 1500-1504.
Chicago
Tsuruta, N., Takayoshi, K., Arita, S., Aikawa, T., Ariyama, H., Kusaba, H., Ohuchida, K., Nagai, E., Kohashi, K., Hirahashi, M., Inadomi, K., Tanaka, M., Sagara, K., Okumura, Y., Nio, K., Nakano, M., Nakamura, M., Oda, Y., Akashi, K., Baba, E."Systemic chemotherapy with pronounced efficacy and neutropenia in a granulocyte-colony stimulating factor-producing advanced gastric neuroendocrine carcinoma". Oncology Letters 14, no. 2 (2017): 1500-1504. https://doi.org/10.3892/ol.2017.6299
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