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Case Report Open Access

Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review

  • Authors:
    • Saad Alqahtani
    • Amal Y. Alhefdhi
    • Osama Almalik
    • Ihab Anwar
    • Rana Mahmood
    • Zeyad Mahasin
    • Taher Al‑Tweigeri
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, College of Medicine, Al Majmaah University, Academic City, Al Majmaah 15341, Kingdom of Saudi Arabia, Department of General Surgery, King Faisal Specialist Hospital and Research Centre, Alfaisal University, Riyadh 11211, Kingdom of Saudi Arabia, Department of Radiation Oncology, Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Kingdom of Saudi Arabia, Department of Otolaryngology, Head and Neck Surgery and Communication, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Kingdom of Saudi Arabia, Department of Medical Oncology, Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Kingdom of Saudi Arabia
    Copyright: © Alqahtani et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1275-1280
    |
    Published online on: June 2, 2017
       https://doi.org/10.3892/ol.2017.6304
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Abstract

Primary oral malignant melanoma is a rare tumor, which is estimated to comprise 0.2‑8.0% of all melanoma cases. This type of cancer is fairly uncommon, its prognosis is dismal, and it frequently exhibits a biologically aggressive behavior. The common location of primary oral malignant melanoma is the hard palate and maxillary alveolus. In ~85% of cases, the melanoma will metastasize to the liver, lung, bone and brain early in the course of the disease. The present study reports the case of a 50‑year‑old premenopausal woman who presented with primary oral malignant spindle cell melanoma (T3bN2aM0) and underwent complete surgical resection followed by an adjuvant course of radiation therapy. After 1 year, the patient presented with sudden onset slurred speech, and upon examination, was found to have left‑sided hemiparesis and a hard left breast mass. Workup confirmed breast and brain metastasis. The patient developed lung metastasis 4 weeks later and was referred for palliative care.
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Copy and paste a formatted citation
Spandidos Publications style
Alqahtani S, Alhefdhi AY, Almalik O, Anwar I, Mahmood R, Mahasin Z and Al‑Tweigeri T: Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review. Oncol Lett 14: 1275-1280, 2017.
APA
Alqahtani, S., Alhefdhi, A.Y., Almalik, O., Anwar, I., Mahmood, R., Mahasin, Z., & Al‑Tweigeri, T. (2017). Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review. Oncology Letters, 14, 1275-1280. https://doi.org/10.3892/ol.2017.6304
MLA
Alqahtani, S., Alhefdhi, A. Y., Almalik, O., Anwar, I., Mahmood, R., Mahasin, Z., Al‑Tweigeri, T."Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review". Oncology Letters 14.2 (2017): 1275-1280.
Chicago
Alqahtani, S., Alhefdhi, A. Y., Almalik, O., Anwar, I., Mahmood, R., Mahasin, Z., Al‑Tweigeri, T."Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review". Oncology Letters 14, no. 2 (2017): 1275-1280. https://doi.org/10.3892/ol.2017.6304
Copy and paste a formatted citation
x
Spandidos Publications style
Alqahtani S, Alhefdhi AY, Almalik O, Anwar I, Mahmood R, Mahasin Z and Al‑Tweigeri T: Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review. Oncol Lett 14: 1275-1280, 2017.
APA
Alqahtani, S., Alhefdhi, A.Y., Almalik, O., Anwar, I., Mahmood, R., Mahasin, Z., & Al‑Tweigeri, T. (2017). Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review. Oncology Letters, 14, 1275-1280. https://doi.org/10.3892/ol.2017.6304
MLA
Alqahtani, S., Alhefdhi, A. Y., Almalik, O., Anwar, I., Mahmood, R., Mahasin, Z., Al‑Tweigeri, T."Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review". Oncology Letters 14.2 (2017): 1275-1280.
Chicago
Alqahtani, S., Alhefdhi, A. Y., Almalik, O., Anwar, I., Mahmood, R., Mahasin, Z., Al‑Tweigeri, T."Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review". Oncology Letters 14, no. 2 (2017): 1275-1280. https://doi.org/10.3892/ol.2017.6304
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