Composite Nasopharyngeal plasmacytoma with nodal paraimmunoblastic variant of small lymphocytic lymphoma: A case report

Nalbandyan,Karen; Benharroch,Daniel; Rouvio,Ory; Gurevitch,Anna

doi:10.3892/ol.2017.6308

Composite Nasopharyngeal plasmacytoma with nodal paraimmunoblastic variant of small lymphocytic lymphoma: A case report

Authors:
- Karen Nalbandyan
- Daniel Benharroch
- Ory Rouvio
- Anna Gurevitch
View Affiliations

Affiliations: Department of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of The Negev, Beer‑Sheva 84101, Israel, Department of Hematology, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of The Negev, Beer‑Sheva 84101, Israel
Published online on: June 2, 2017 https://doi.org/10.3892/ol.2017.6308
Pages: 1745-1747

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

A 78‑year‑old male who presented with severe shortness of breath and bilateral nasal congestion was shown to exhibit ta mass localized in the nasopharynx. The tumor was diagnosed as an extramedullary plasmacytoma. Peripheral blood eosinophilia had been persistently noted in the preceding 12 years. The plasmacytoma exhibited a predominance of κ‑light chain monotypic Mott cells and was admixed with numerous eosinophils. No history of allergic rhinitis, asthma or aspirin sensitivity was elicited. An axillary lymph node was excised two weeks after the nasopharyngeal biopsy, and it exhibited a paraimmunoblastic transformation of small lymphocytic lymphoma. A review of the literature identified few occurrences of such simultaneous tumors in individual patients.

View Figures

View References

1	Chang YL, Chen PY and Hung SH: Extramedullary plasmacytoma of the nasopharynx: A case report and review of the literature. Oncol Lett. 7:458–460. 2014.PubMed/NCBI
2	Ichimura K, Sugimura H, Naito A and Maeda Y: How to manage patients with hard to recognize postnasal drip? Rhinology. 37:164–167. 1999.PubMed/NCBI
3	Kroft SH, Dawson DB and McKenna RW: Large cell lymphoma transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma. A flow cytometry analysis of seven cases. Am J ClinPathol. 115:385–395. 2001.
4	Creach KM, Foote RL, Neben-Wittich MA and Kyle RA: Radiotherapy for extramedullary plasmacytoma of the head and neck. Int J Radiat Oncol Biol Phys. 73:789–794. 2009. View Article : Google Scholar : PubMed/NCBI
5	Tournier-Rangeard L, Lapeyre M, Graff-Caillaud P, Mege A, Dolivet G, Toussaint B, Charra-Brunaud C, Hoffstetter S, Marchal C and Peiffert D: Radiotherapy for solitary extramedullary plasmacytoma in the head and neck region: A dose greater than 45 Gy to the target volume improves the local control. Int J Radiat Oncol Biol Phys. 64:1013–1017. 2006. View Article : Google Scholar : PubMed/NCBI
6	Horiguti S: Asthma and nasopharyngitis. Allerg Immunol (Leipz). 20-21:1–425. 1975.
7	Obtulowicz K, Chlap Z and Olszewski E: Bronchial asthma and pathological processes of the nasopharynx. I Clinical analysis during remission and attack. Ann Allergy. 42:44–48. 1979.PubMed/NCBI
8	Rebhun J: A new approach to the treatment of allergic nasopharyngitis. Ann Allergy. 39:175–178. 1977.PubMed/NCBI
9	Chantepie SP, Cabrera Q, Mear JB, Salaun V, Lechapt-Zalcman E and Macro M: Unusual extramedullary plasmacytoma: A rare but possible cause of lymphadenopathy in chronic lymphocytic leukemia. Case Rep Med. 2015:6570492015. View Article : Google Scholar : PubMed/NCBI
10	Yahata N, Iwase O, Iwama H, Tauchi T, Kawanishi Y, Serizawa H and Ohyashiki K: Chronic lymphocytic leukemia complicated by plasmacytoma originating from different clones. Leuk Lymphoma. 39:203–207. 2000. View Article : Google Scholar : PubMed/NCBI
11	Pines A, Ben-Bassat I, Selzer G and Ramot B: Transformation of chronic lymphocytic leukemia to plasmacytoma. Cancer. 54:1904–1907. 1984. View Article : Google Scholar : PubMed/NCBI
12	Chuang SS, Liao YL, Liou CP, Wiggins ML, Ye H, Du MQ, Isaacson PG and Chang CC: Chronic lymphocytic leukemia with paraimmunoblastic transformation - with comparative genomic hybridization and review of the literature. Pathol Res Pract. 206:276–281. 2010. View Article : Google Scholar : PubMed/NCBI
13	Sakata S, Tsuyama N and Takeuchi K: Pathology of indolent B-cell neoplasms other than follicular lymphoma. J Clin Exp Hematop. 54:11–22. 2014. View Article : Google Scholar : PubMed/NCBI