Open Access

Role of the long non-coding RNA HOTAIR in hepatocellular carcinoma (Review)

  • Authors:
    • Liming Wu
    • Lele Zhang
    • Shusen Zheng
  • View Affiliations

  • Published online on: June 6, 2017     https://doi.org/10.3892/ol.2017.6312
  • Pages: 1233-1239
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A number of recent studies have focused on the association between long non-coding RNAs (lncRNAs) and cancer. HOX transcript antisense RNA (HOTAIR), an lncRNA that functions as a transcriptional modulator, has been implicated in various fundamental biological activities. HOTAIR mediates the trimethylation of histone H3 at lysine 27 and the demethylation of histone H3 dimethyl Lys4 by recruiting the polycomb repressive complex 2 and the lysine‑specific demethylase 1/co‑repressor of RE1‑silencing transcription factor (coREST)/REST complex to the target gene promoters, which leads to gene silencing. Overexpression of HOTAIR in hepatocellular carcinoma (HCC) is strongly associated with an unfavorable prognosis for patients with HCC. HOTAIR promotes the carcinogenic activity of HCC cells through the suppression of RNA binding motif protein 38, triggering the epithelial‑mesenchymal transition, and by interacting with microRNAs that act as tumor suppressors. In the present review, the role of the lncRNA HOTAIR in HCC is examined. The potential use of HOTAIR as a biomarker to achieve more accurate prognostic predictions and as an effective therapeutic target for HCC is then discussed.
View Figures
View References

Related Articles

Journal Cover

August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wu L, Zhang L and Zheng S: Role of the long non-coding RNA HOTAIR in hepatocellular carcinoma (Review). Oncol Lett 14: 1233-1239, 2017
APA
Wu, L., Zhang, L., & Zheng, S. (2017). Role of the long non-coding RNA HOTAIR in hepatocellular carcinoma (Review). Oncology Letters, 14, 1233-1239. https://doi.org/10.3892/ol.2017.6312
MLA
Wu, L., Zhang, L., Zheng, S."Role of the long non-coding RNA HOTAIR in hepatocellular carcinoma (Review)". Oncology Letters 14.2 (2017): 1233-1239.
Chicago
Wu, L., Zhang, L., Zheng, S."Role of the long non-coding RNA HOTAIR in hepatocellular carcinoma (Review)". Oncology Letters 14, no. 2 (2017): 1233-1239. https://doi.org/10.3892/ol.2017.6312