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Article

WNT1-inducible signaling pathway protein-1 contributes to tumor progression and treatment failure in oral squamous cell carcinoma

  • Authors:
    • Eun Kyung Jung
    • Sun‑Ae Kim
    • Tae Mi Yoon
    • Kyung‑Hwa Lee
    • Hee Kyung Kim
    • Dong Hoon Lee
    • Joon Kyoo Lee
    • Ik‑Joo Chung
    • Young‑Eun Joo
    • Sang Chul Lim
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology‑Head and Neck Surgery, Chonnam National University Medical School, Gwangju, Chonnam 58128, Republic of Korea, Department of Pathology, Chonnam National University Medical School, Gwangju, Chonnam 58128, Republic of Korea, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Chonnam 58128, Republic of Korea
  • Pages: 1719-1724
    |
    Published online on: June 6, 2017
       https://doi.org/10.3892/ol.2017.6313
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Abstract

WNT1-inducible-signaling pathway protein-1 (WISP-1) belongs to the family of cysteine rich 61/connective tissue growth factor/nephroblastoma overexpressed matricellular proteins, which are involved in various biological processes, including cell adhesion, proliferation, differentiation, angiogenesis and carcinogenesis. In the present study, the expression of WISP‑1 was investigated, and its association with clinicopathological factors and prognosis in patients with oral squamous cell carcinoma (OSCC) was evaluated. Additionally, the role of WISP‑1 in invasion and apoptosis of human OSCC cells was evaluated. Immunoreactivity of WISP‑1 was increased in OSCC tissue compared with adjacent normal tissue samples. High expression of WISP‑1 protein was observed in 24/84 (28.57%) OSCC specimens. Additionally, high WISP‑1 expression was significantly associated with treatment failure (P=0.042). The 5‑year overall survival rate was 33% in patients with high WISP1 expression, and 66% in patients with low WISP‑1 expression. WISP‑1 expression in the human OSCC SCC‑1483 cell line was observed. Furthermore, WISP‑1 knockdown using small interfering (si)RNA significantly reduced cell invasion and induced apoptosis compared with control siRNA‑transfected cells. These findings suggested that WISP‑1 is associated with tumor progression and poor prognosis by increasing tumor cell invasion and inhibiting cell apoptosis in human OSCC.
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View References

1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Kleer CG, Zhang Y, Pan Q and Merajver SD: WISP3 (CCN6) is a secreted tumor-suppressor protein that modulates IGF signaling in inflammatory breast cancer. Neoplasia. 6:179–185. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Holbourn KP, Acharya KR and Perbal B: The CCN family of proteins: Structure-function relationships. Trends Biochem Sci. 33:461–473. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Perbal B: NOV (nephroblastoma overexpressed) and the CCN family of genes: Structural and functional issues. Mol Pathol. 54:57–79. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Pennica D, Swanson TA, Welsh JW, Roy MA, Lawrence DA, Lee J, Brush J, Taneyhill LA, Deuel B, Lew M, et al: WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci USA. 95:pp. 14717–14722. 1998; View Article : Google Scholar : PubMed/NCBI

6 

Calvisi DF, Conner EA, Ladu S, Lemmer ER, Factor VM and Thorgeirsson SS: Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer. J Hepatol. 42:842–849. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Margalit O, Eisenbach L, Amariglio N, Kaminski N, Harmelin A, Pfeffer R, Shohat M, Rechavi G and Berger R: Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines. Br J Cancer. 89:314–319. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Xie D, Nakachi K, Wang H, Elashoff R and Koeffler HP: Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res. 61:8917–8923. 2001.PubMed/NCBI

9 

Konigshoff M, Kramer M, Balsara N, Wilhelm J, Amarie OV, John A, Rose F, Fink L, Seeger W, Schaefer L, et al: WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest. 119:772–787. 2009.PubMed/NCBI

10 

Tian C, Zhou ZG, Meng WJ, Sun XF, Yu YY, Li L, Luo HZ, Yang L, Zhou B and Gu J: Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients. World J Gastroenterol. 13:3878–3882. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL and Tritti A: American joint committee on cancer-cancer staging manual. 7th. New York: Springer; 2010

12 

Myung DS, Park YL, Chung CY, Park HC, Kim JS, Cho SB, Lee WS, Lee KH, Lee JH and Joo YE: Expression of Livin in colorectal cancer and its relationship to tumor cell behavior and prognosis. PLoS One. 8:e732622013. View Article : Google Scholar : PubMed/NCBI

13 

Nagai Y, Watanabe M, Ishikawa S, Karashima R, Kurashige J, Iwagami S, Iwatsuki M, Baba Y, Imamura Y, Hayashi N and Baba H: Clinical significance of Wnt-induced secreted protein-1 (WISP-1/CCN4) in esophageal squamous cell carcinoma. Anticancer Res. 31:991–997. 2011.PubMed/NCBI

14 

Tang Q, Jiang X, Li H, Lin Z, Zhou X, Luo X, Liu L and Chen G: Expression and prognostic value of WISP-1 in patients with endometrial adenocarcinoma. J Obstet Gynaecol Res. 37:606–612. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Chen PP, Li WJ, Wang Y, Zhao S, Li DY, Feng LY, Shi XL, Koeffler HP, Tong XJ and Xie D: Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer. PLoS One. 2:e5342007. View Article : Google Scholar : PubMed/NCBI

16 

Chuang JY, Chang AC, Chiang IP, Tsai MH and Tang CH: Apoptosis signal-regulating kinase 1 is involved in wisp-1-promoted cell motility in human oral squamous cell carcinoma cells. PLoS One. 8:e780222013. View Article : Google Scholar : PubMed/NCBI

17 

Igney FH and Krammer PH: Death and anti-death: Tumour resistance to apoptosis. Nat Rev Cancer. 2:277–288. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Jung J, Cho NH, Kim J, Choi EC, Lee SY, Byeon HK, Park YM, Yang WS and Kim SH: Significant invasion depth of early oral tongue cancer originated from the lateral border to predict regional metastases and prognosis. Int J Oral Maxillofac Surg. 38:653–660. 2009. View Article : Google Scholar : PubMed/NCBI

19 

You Z, Saims D, Chen S, Zhang Z, Guttridge DC, Guan KL, MacDougald OA, Brown AM, Evan G, Kitajewski J and Wang CY: Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. Cell Biol. 157:429–440. 2002. View Article : Google Scholar

20 

Su F, Overholtzer M, Besser D and Levine AJ: WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev. 16:46–57. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jung EK, Kim SA, Yoon TM, Lee KH, Kim HK, Lee DH, Lee JK, Chung IJ, Joo YE, Lim SC, Lim SC, et al: WNT1-inducible signaling pathway protein-1 contributes to tumor progression and treatment failure in oral squamous cell carcinoma. Oncol Lett 14: 1719-1724, 2017.
APA
Jung, E.K., Kim, S., Yoon, T.M., Lee, K., Kim, H.K., Lee, D.H. ... Lim, S.C. (2017). WNT1-inducible signaling pathway protein-1 contributes to tumor progression and treatment failure in oral squamous cell carcinoma. Oncology Letters, 14, 1719-1724. https://doi.org/10.3892/ol.2017.6313
MLA
Jung, E. K., Kim, S., Yoon, T. M., Lee, K., Kim, H. K., Lee, D. H., Lee, J. K., Chung, I., Joo, Y., Lim, S. C."WNT1-inducible signaling pathway protein-1 contributes to tumor progression and treatment failure in oral squamous cell carcinoma". Oncology Letters 14.2 (2017): 1719-1724.
Chicago
Jung, E. K., Kim, S., Yoon, T. M., Lee, K., Kim, H. K., Lee, D. H., Lee, J. K., Chung, I., Joo, Y., Lim, S. C."WNT1-inducible signaling pathway protein-1 contributes to tumor progression and treatment failure in oral squamous cell carcinoma". Oncology Letters 14, no. 2 (2017): 1719-1724. https://doi.org/10.3892/ol.2017.6313
Copy and paste a formatted citation
x
Spandidos Publications style
Jung EK, Kim SA, Yoon TM, Lee KH, Kim HK, Lee DH, Lee JK, Chung IJ, Joo YE, Lim SC, Lim SC, et al: WNT1-inducible signaling pathway protein-1 contributes to tumor progression and treatment failure in oral squamous cell carcinoma. Oncol Lett 14: 1719-1724, 2017.
APA
Jung, E.K., Kim, S., Yoon, T.M., Lee, K., Kim, H.K., Lee, D.H. ... Lim, S.C. (2017). WNT1-inducible signaling pathway protein-1 contributes to tumor progression and treatment failure in oral squamous cell carcinoma. Oncology Letters, 14, 1719-1724. https://doi.org/10.3892/ol.2017.6313
MLA
Jung, E. K., Kim, S., Yoon, T. M., Lee, K., Kim, H. K., Lee, D. H., Lee, J. K., Chung, I., Joo, Y., Lim, S. C."WNT1-inducible signaling pathway protein-1 contributes to tumor progression and treatment failure in oral squamous cell carcinoma". Oncology Letters 14.2 (2017): 1719-1724.
Chicago
Jung, E. K., Kim, S., Yoon, T. M., Lee, K., Kim, H. K., Lee, D. H., Lee, J. K., Chung, I., Joo, Y., Lim, S. C."WNT1-inducible signaling pathway protein-1 contributes to tumor progression and treatment failure in oral squamous cell carcinoma". Oncology Letters 14, no. 2 (2017): 1719-1724. https://doi.org/10.3892/ol.2017.6313
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