Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population

  • Authors:
    • Wen Li
    • Shuang Shuang Wang
    • Jing Deng
    • Jian Xin Tang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou, Hunan 412007, P.R. China, College of Packaging and Material Engineering, Hunan University of Technology, Zhuzhou, Hunan 412007, P.R. China
  • Pages: 1817-1822
    |
    Published online on: June 7, 2017
       https://doi.org/10.3892/ol.2017.6327
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the association of p73 G4C14-A4T14 polymorphism and murine double minute 2 (MDM2) 309 T/G single nucleotide polymorphisms (SNPs) with the risk of developing non‑small cell lung cancer (NSCLC) in Sothern China. The p73 and MDM2 genotypes of peripheral blood DNA from 186 patients with NSCLC and 196 normal controls were detected by polymerase chain reaction (PCR) with confronting two‑pair primers (CTPP) and high resolution melting (HRM), respectively. The results of genotyping were consistent with those of direct sequencing. The p73 AT/AT [odds ratio (OR)=0.46; 95% confidence interval (CI)=0.22‑0.97] and MDM2 TT (OR=0.48; 95% CI=0.26‑0.86) genotypes were associated with a decreased risk of developing NSCLC compared with that of the p73 GC/GC and MDM2 GG genotypes, respectively. In addition, the interaction between the p73 and MDM2 polymorphisms reduced the risk of developing NSCLC in multiple ways (OR=0.13; 95% CI=0.03‑0.59) for subjects carrying both the p73 AT/AT and MDM2 TT genotypes. Therefore, the SNP in p73 G4C14‑A4T14 and the MDM2 309 polymorphism may be markers of genetic susceptibility to NSCLC in a Chinese population, and there is a possible gene‑gene interaction involved in the incidence of NSCLC.
View Figures

Figure 1

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Zhou BB and Elledge SJ: The DNA damage response: Putting checkouts in perspective. Nature. 408:433–439. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Hu ZB, Ma HX, Tan W, et al: The research between genetic susceptibility to lung cancer and p73 gene polymorphism. Chin J Epidemiol. 26:106–109. 2005.

4 

Cheng Z, Wang W, Song YN, Kang Y and Xia J: hoGG1, p53 genes and smoking interactions are associated with the development of lung cancer. Asian Pac J Cancer Prev. 13:1803–1808. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, et al: Monoallelically expressed gene related to p53 at lp36, a region frequently deleted in neuroblastoma and other human cancers. Cell. 90:809–819. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Melino G, De Laurenzi V and Vousden KH: p73: Friend or foe in tumorigenesis. Nat Rev Cancer. 2:605–615. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Peters MA, Janer M, Kolb S, Jarvik GP, Ostrander EA and Stanford JL: Germline mutations in the p73 gene do not predispose to familial prostate-brain cancer. Prostate. 48:292–296. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Ryan BM, Mcmanus R, Daly JS, Carton E, Keeling PW, Reynolds JV and Kelleher D: A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma. Br J Cancer. 85:1499–1503. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Huang XE, Hamajima N, Katsuda N, Matsuo K, Hirose K, Mizutani M, Iwata H, Miura S, Xiang J, Tokudome S and Tajima K: Association of p53 codon Arg72pro and p73 G4C14-to-A4T14 at exon 2 genetic polymorphisms with the risk of Japanese breast cancer. Breast Cancer. 10:307–311. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Li G, Sturgis EM, Wang LE, Chamberlain RM, Amos CI, Spitz MR, El-Naggar AK, Hong WK and Wei Q: Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck. Carcinogenesis. 25:1911–1916. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Lee KE, Hong YS, Kim BG, Kim NY, Lee KM, Kwak JY and Roh MS: p73 G4C14 to A4T14 polymorphism is associated with colorectal cancer risk and survival. World J Gastroenterol. 16:4448–4454. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Niwa Y, Hamajima N, Atsuta Y, Yamamoto K, Tamakoshi A, Saito T, Hirose K, Nakanishi T, Nawa A, Kuzuya K and Tajima K: Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical cancer in Japanese. Cancer Lett. 205:55–60. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Pfeifer D, Arbman G and Sun XF: Polymorphism of the p73 gene in relation to colorectal cancer risk and survival. Carcinogenesis. 26:103–107. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Niwa Y, Hirose K, Matsuo K, Tajima K, Ikoma Y, Nakanishi T, Nawa A, Kuzuya K, Tamakoshi A and Hamajima N: Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk of endometrial cancer in Japanese subjects. Cancer Lett. 219:183–190. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Li G, Wang LE, Chamberlain RM, Amos CI, Spitz MR and Wei Q: p73 G4C14-to-A4T14 polymorphism and risk of lung cancer. Cancer Res. 64:6863–6866. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Hu Z, Miao X, Ma H, Tan W, Wang X, Lu D, Wei Q, Lin D and Shen H: Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population. Int J Cancer. 114:455–460. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Zhang X, Li X, Wu Z, Lin F and Zhou H: The p73 G4C14-to-A4T14 polymorphism is associated with risk of lung cancer in the Han Nationality of North China. Mol Carcinog. 52:387–391. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Ozaki T and Nakagawara A: p73, a sophisticated p53 family member in the cancer world. Cancer Sci. 96:729–737. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Levrero M, De Laurenzi V, Costanzo A, Gong J, Melino G and Wang JY: Structure, function and regulation of p63 and p73. Cell Death Differ. 6:1146–1153. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Zeng X, Chen L, Jost CA, Maya R, Keller D, Wang X, Kaelin WG Jr, Oren M, Chen J and Lu H: MDM2 suppresses p73 function without promoting p73 degradation. Mol Cell Biol. 19:3257–3266. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Lundgren K, de Oca Luna R Montes, McNeill YB, Emerick EP, Spencer B, Barfield CR, Lozano G, Rosenberg MP and Finlay CA: Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev. 11:714–725. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Bond GL, Hu W, Bond EE, Robins H, Lutzker SG, Arva NC, Bargonetti J, Bartel F, Taubert H, Wuerl P, et al: A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell. 119:591–602. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Bougeard G, Baert-Desurmont S, Tournier I, Vasseur S, Martin C, Brugieres L, Chompret A, Bressac-de Paillerets B, Stoppa-Lyonnet D, Bonaiti-Pellie C and Frebourg T: Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age tumor onset in Li-Fraumeni syndrome. J Med Genet. 43:531–533. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Cheng H, Xie L, Hu WJ, et al: Detection of the MDM2 SNP309 by QRT-PCR. J Clin Oncol. 16:577–581. 2011.

25 

Wang SS, Guo HY, Dong LL, Zhu XQ, Ma L, Li W and Tang JX: Association between a p73 gene polymorphism and genetic susceptibility to non-small cell lung cancer in the South of China. Asian Pac J Cancer Prev. 15:10387–19391. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Zhu J, Jiang J, Zhou W and Chen X: The potential tumor suppressor p73 differently regulates cellular p53 target genes. Cancer Res. 58:5061–5065. 1998.PubMed/NCBI

27 

Jost CA, Marin MC and Kaelin WG Jr: p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature. 389:191–194. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Hamajima N, Matsuo K, Suzuki T, Nakamura T, Matsuura A, Hatooka S, Shinoda M, Kodera Y, Yamamura Y, Hirai T, et al: No association of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphism with the risk of digestive tract cancers in Japanese. Cancer Lett. 181:81–85. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Choi JE, Kang HG, Chae MH, Kim EJ, Lee WK, Cha SI, Kim CH, Jung TH and Park JY: No association between p73 G4C14-to-A4T14 polymorphism and the risk of lung cancer in a Korean population. Biochem Genet. 44:543–550. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Bond GL, Hirshfield KM, Kirchhoff T, Alexe G, Bond EE, Robins H, Bartel F, Taubert H, Wuerl P, Hait W, et al: MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. Cancer Res. 66:5104–5110. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Jun HJ, Park SH, Lee WK, Choi JE, Jang JS, Kim EJ, Cha SI, Kim DS, Kam S, Kim CH, et al: Combined effects off p73 and MDM2 polymorphisms on the risk of lung cancer. Mol Carcinog. 46:100–105. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Zhang X, Miao X, Guo Y, Tan W, Zhou Y, Sun T, Wang Y and Lin D: Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. Hum Mutat. 27:110–117. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Ma H, Hu Z, Zhai X, Wang S, Wang X, Qin J, Jin G, Liu J, Wang X, Wei Q and Shen H: Polymorphisms in the MDM2 promoter and risk of breast cancer: A case-control analysis in a Chinese population. Cancer Lett. 240:261–267. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Campbell IG, Eccles DM and Choong DY: No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer. Cancer Lett. 240:195–197. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Hu Z, Ma H, Lu D, Qian J, Zhou J, Chen Y, Xu L, Wang X, Wei Q and Shen H: Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population. Int J Cancer. 118:1275–1278. 2006. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li W, Wang SS, Deng J and Tang JX: Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population. Oncol Lett 14: 1817-1822, 2017.
APA
Li, W., Wang, S.S., Deng, J., & Tang, J.X. (2017). Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population. Oncology Letters, 14, 1817-1822. https://doi.org/10.3892/ol.2017.6327
MLA
Li, W., Wang, S. S., Deng, J., Tang, J. X."Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population". Oncology Letters 14.2 (2017): 1817-1822.
Chicago
Li, W., Wang, S. S., Deng, J., Tang, J. X."Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population". Oncology Letters 14, no. 2 (2017): 1817-1822. https://doi.org/10.3892/ol.2017.6327
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Wang SS, Deng J and Tang JX: Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population. Oncol Lett 14: 1817-1822, 2017.
APA
Li, W., Wang, S.S., Deng, J., & Tang, J.X. (2017). Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population. Oncology Letters, 14, 1817-1822. https://doi.org/10.3892/ol.2017.6327
MLA
Li, W., Wang, S. S., Deng, J., Tang, J. X."Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population". Oncology Letters 14.2 (2017): 1817-1822.
Chicago
Li, W., Wang, S. S., Deng, J., Tang, J. X."Association of p73 gene G4C14-A4T14 polymorphism and MDM2 gene SNP309 with non-small cell lung cancer risk in a Chinese population". Oncology Letters 14, no. 2 (2017): 1817-1822. https://doi.org/10.3892/ol.2017.6327
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team