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Review Open Access

Circulating tumor cells in prostate cancer: Precision diagnosis and therapy (Review)

  • Authors:
    • Weiwei Liu
    • Binbin Yin
    • Xuchu Wang
    • Pan Yu
    • Xiuzhi Duan
    • Chunhua Liu
    • Ben Wang
    • Zhihua Tao
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1223-1232
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    Published online on: June 7, 2017
       https://doi.org/10.3892/ol.2017.6332
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Abstract

The primary cause of tumor-associated mortality in prostate cancer (PCa) remains distant metastasis. The dissemination of tumor cells from the primary tumor to distant sites through the bloodstream cannot be detected early by standard imaging methods. Circulating tumor cells (CTCs) represent an effective prognostic and predictive biomarker, which are able to monitor efficacy of adjuvant therapies, detect early development of metastases, and finally, assess therapeutic responses of advanced disease earlier than traditional diagnostic methods. In addition, since repeated tissue biopsies are invasive, costly and not always feasible, the assessment of tumor characteristics on CTCs, by a peripheral blood sample as a liquid biopsy, represents an attractive opportunity. The implementation of molecular and genomic characterization of CTCs may contribute to improve the treatment selection and thus, to move toward more precise diagnosis and therapy in PCa. The present study summarizes the current advances in CTC enrichment and detection strategies and reviews how CTCs may contribute to significant insights in the metastatic process, as well as how they may be utilized in clinical application in PCa. Although it is proposed that CTCs may offer insights into the prognosis and management of PCa, there are a number of challenges in the study of circulating tumor cells, and their clinical utility remains under investigation.
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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Yin B, Wang X, Yu P, Duan X, Liu C, Wang B and Tao Z: Circulating tumor cells in prostate cancer: Precision diagnosis and therapy (Review). Oncol Lett 14: 1223-1232, 2017.
APA
Liu, W., Yin, B., Wang, X., Yu, P., Duan, X., Liu, C. ... Tao, Z. (2017). Circulating tumor cells in prostate cancer: Precision diagnosis and therapy (Review). Oncology Letters, 14, 1223-1232. https://doi.org/10.3892/ol.2017.6332
MLA
Liu, W., Yin, B., Wang, X., Yu, P., Duan, X., Liu, C., Wang, B., Tao, Z."Circulating tumor cells in prostate cancer: Precision diagnosis and therapy (Review)". Oncology Letters 14.2 (2017): 1223-1232.
Chicago
Liu, W., Yin, B., Wang, X., Yu, P., Duan, X., Liu, C., Wang, B., Tao, Z."Circulating tumor cells in prostate cancer: Precision diagnosis and therapy (Review)". Oncology Letters 14, no. 2 (2017): 1223-1232. https://doi.org/10.3892/ol.2017.6332
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Yin B, Wang X, Yu P, Duan X, Liu C, Wang B and Tao Z: Circulating tumor cells in prostate cancer: Precision diagnosis and therapy (Review). Oncol Lett 14: 1223-1232, 2017.
APA
Liu, W., Yin, B., Wang, X., Yu, P., Duan, X., Liu, C. ... Tao, Z. (2017). Circulating tumor cells in prostate cancer: Precision diagnosis and therapy (Review). Oncology Letters, 14, 1223-1232. https://doi.org/10.3892/ol.2017.6332
MLA
Liu, W., Yin, B., Wang, X., Yu, P., Duan, X., Liu, C., Wang, B., Tao, Z."Circulating tumor cells in prostate cancer: Precision diagnosis and therapy (Review)". Oncology Letters 14.2 (2017): 1223-1232.
Chicago
Liu, W., Yin, B., Wang, X., Yu, P., Duan, X., Liu, C., Wang, B., Tao, Z."Circulating tumor cells in prostate cancer: Precision diagnosis and therapy (Review)". Oncology Letters 14, no. 2 (2017): 1223-1232. https://doi.org/10.3892/ol.2017.6332
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