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Review Open Access

Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy (Review)

  • Authors:
    • Ling‑Li Huang
    • Ling‑Wei Huang
    • Lei Wang
    • Ben‑Ding Tong
    • Qing Wei
    • Xuan‑Sheng Ding
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China, Key Laboratory for Space Biosciences and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shanxi 710072, P.R. China, Department of Pharmacy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1215-1222
    |
    Published online on: June 8, 2017
       https://doi.org/10.3892/ol.2017.6351
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Abstract

MicroRNAs (miRNAs) are short non‑coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, including cancer. Among the miRNAs, differential expression of miR-139-5p serves a significant role in tumorigenesis, metastasis and recurrence, thus suggesting that it may potentially be used as a promising biomarker for cancer diagnosis, prognosis and therapy. miR‑139‑5p is expected to serve as a biomarker to eventually be implemented in a clinical setting. In the present review, we focus on the importance of miR-139-5p in cancer, summarize the association between miR‑139‑5p expression level and diagnosis and prognosis, and discuss the potential therapeutic implications for the future.
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Copy and paste a formatted citation
Spandidos Publications style
Huang LL, Huang LW, Wang L, Tong BD, Wei Q and Ding XS: Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy (Review). Oncol Lett 14: 1215-1222, 2017.
APA
Huang, L., Huang, L., Wang, L., Tong, B., Wei, Q., & Ding, X. (2017). Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy (Review). Oncology Letters, 14, 1215-1222. https://doi.org/10.3892/ol.2017.6351
MLA
Huang, L., Huang, L., Wang, L., Tong, B., Wei, Q., Ding, X."Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy (Review)". Oncology Letters 14.2 (2017): 1215-1222.
Chicago
Huang, L., Huang, L., Wang, L., Tong, B., Wei, Q., Ding, X."Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy (Review)". Oncology Letters 14, no. 2 (2017): 1215-1222. https://doi.org/10.3892/ol.2017.6351
Copy and paste a formatted citation
x
Spandidos Publications style
Huang LL, Huang LW, Wang L, Tong BD, Wei Q and Ding XS: Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy (Review). Oncol Lett 14: 1215-1222, 2017.
APA
Huang, L., Huang, L., Wang, L., Tong, B., Wei, Q., & Ding, X. (2017). Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy (Review). Oncology Letters, 14, 1215-1222. https://doi.org/10.3892/ol.2017.6351
MLA
Huang, L., Huang, L., Wang, L., Tong, B., Wei, Q., Ding, X."Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy (Review)". Oncology Letters 14.2 (2017): 1215-1222.
Chicago
Huang, L., Huang, L., Wang, L., Tong, B., Wei, Q., Ding, X."Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy (Review)". Oncology Letters 14, no. 2 (2017): 1215-1222. https://doi.org/10.3892/ol.2017.6351
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