Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Hereditary diffuse gastric cancer in two families: A case report

  • Authors:
    • Irene Feroce
    • Davide Serrano
    • Roberto Biffi
    • Bruno Andreoni
    • Viviana Galimberti
    • Angelica Sonzogni
    • Luca Bottiglieri
    • Edoardo Botteri
    • Cristina Trovato
    • Monica Marabelli
    • Guglielmina Nadia Ranzani
    • Bernardo Bonanni
  • View Affiliations / Copyright

    Affiliations: Division of Cancer Prevention and Genetics, European Institute of Oncology, I‑20141 Milan, Italy, Division of Abdomino‑Pelvic Surgery, European Institute of Oncology, I‑20141 Milan, Italy, Division of Palliative Care, European Institute of Oncology, I‑20141 Milan, Italy, Unit of Molecular Senology, European Institute of Oncology, I‑20141 Milan, Italy, Division of Pathology, European Institute of Oncology, I‑20141 Milan, Italy, Division of Epidemiology and Biostatistics, European Institute of Oncology, I‑20141 Milan, Italy, Division of Endoscopy, European Institute of Oncology, I‑20141 Milan, Italy, Department of Biology and Biotechnology, University of Pavia, I‑27100 Pavia, Italy
  • Pages: 1671-1674
    |
    Published online on: June 8, 2017
       https://doi.org/10.3892/ol.2017.6354
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hereditary diffuse gastric cancer (HDGC) is associated with E-cadherin 1 (CDH1) germline mutations. In the present study, two unusual HDGC cases are described. Case 1 was a female with no family history of gastric cancer who developed Hodgkin's lymphoma at 19 years of age, and DGC at 32 years of age. Due to her young age (32 years), the patient was examined for CDH1 abnormalities and a deleterious mutation was identified. Her father and younger sister were identified to be carriers of the mutation. Case 2 was a 36‑year‑old female diagnosed with lobular breast cancer (LBC); her mother had LBC, and her grandmother had LBC and DGC. The molecular test was wild‑type for breast cancer susceptibility genes 1 and 2; however, a large deletion in CDH1 was identified. At prophylactic gastrectomy, early DGC was identified. Early onset of DGC and LBC justifies testing for CDH1. A better knowledge of tumor natural history in carrier subjects is important to aid genetic counseling, in order to assess the surveillance time required prior to carrying out prophylactic surgery.
View Figures

Figure 1

Figure 2

View References

1 

Crew KD and Neugut AI: Epidemiology of gastric cancer. World J Gastroenterol. 12:354–362. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Lauren P: The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 64:31–49. 1965. View Article : Google Scholar : PubMed/NCBI

3 

Howson CP, Hiyama T and Wynder EL: The decline in gastric cancer: Epidemiology of an unplanned triumph. Epidemiol Rev. 8:1–27. 1986. View Article : Google Scholar : PubMed/NCBI

4 

Sepulveda AR: Helicobacter, Inflammation, and Gastric Cancer. Curr Pathobiol Rep. 1:9–18. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Yakirevich E and Resnick MB: Pathology of gastric cancer and its precursor lesions. Gastroenterol Clin North Am. 42:261–284. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Kluijt I, Siemerink EJ, Ausems MG, van Os TA, de Jong D, Simões-Correia J, van Krieken JH, Ligtenberg MJ, Figueiredo J, van Riel E, et al: CDH1-related hereditary diffuse gastric cancer syndrome: Clinical variations and implications for counseling. Int J Cancer. 131:367–376. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Humar B, Blair V, Charlton A, More H, Martin I and Guilford P: E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man. Cancer Res. 69:2050–2056. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Oliveira C, Sousa S, Pinheiro H, Karam R, Bordeira-Carrico R, Senz J, Kaurah P, Carvalho J, Pereira R, Gusmão L, et al: Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology. 136:2137–2148. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Nakayama S, Sasaki A, Mese H, Alcalde RE, Tsuji T and Matsumura T: The E-cadherin gene is silenced by CpG methylation in human oral squamous cell carcinomas. Int J Cancer. 93:667–673. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Brooks-Wilson AR, Kaurah P, Suriano G, Leach S, Senz J, Grehan N, Butterfield YS, Jeyes J, Schinas J, Bacani J, et al: Germline E-cadherin mutations in hereditary diffuse gastric cancer: Assessment of 42 new families and review of genetic screening criteria. J Med Genet. 41:508–517. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Molinaro V, Pensotti V, Marabelli M, Feroce I, Barile M, Pozzi S, Laghi L, Serrano D, Bernard L, Bonanni B and Ranzani GN: Complementary molecular approaches reveal heterogeneous CDH1 germline defects in Italian patients with hereditary diffuse gastric cancer (HDGC) syndrome. Genes Chromosomes Cancer. 53:432–445. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Pharoah PD, Guilford P and Caldas C: International Gastric Cancer Linkage Consortium: Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. Gastroenterology. 121:1348–1353. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Kaurah P, MacMillan A, Boyd N, Senz J, De Luca A, Chun N, Suriano G, Zaor S, Van Manen L, Gilpin C, et al: Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA. 297:2360–2372. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Shah MA, Salo-Mullen E, Stadler Z, Ruggeri JM, Mirander M, Pristyazhnyuk Y and Zhang L: De novo CDH1 mutation in a family presenting with early-onset diffuse gastric cancer. Clin Genet. 82:283–287. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Salmon A, Amikam D, Sodha N, Davidson S, Basel-Vanagaite L, Eeles RA, Abeliovich D and Peretz T: Rapid development of post-radiotherapy sarcoma and breast cancer in a patient with a novel germline ‘de-novo’ TP53 mutation. Clin Oncol (R Coll Radiol). 19:490–493. 2007. View Article : Google Scholar : PubMed/NCBI

16 

McVeigh TP, Choi JK, Miller NM, Green AJ and Kerin MJ: Lobular breast cancer in a CDH1 splice site mutation carrier: Case report and review of the literature. Clin Breast Cancer. 14:e47–e51. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Corso G, Figueiredo J, Biffi R, Trentin C, Bonanni B, Feroce I, Serrano D, Cassano E, Annibale B, Melo S, et al: E-cadherin germline mutation carriers: Clinical management and genetic implications. Cancer Metastasis Rev. 33:1081–1094. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Tan VP and Wong BC: Gastric cancer chemoprevention: The current evidence. Gastroenterol Clin North Am. 42:299–316. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Yadav SK, Sah AK, Jha RK, Sah P and Shah DK: Turmeric (curcumin) remedies gastroprotective action. Pharmacogn Rev. 7:42–46. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Yatsuya H, Toyoshima H, Mizoue T, Kondo T, Tamakoshi K, Hori Y, Tokui N, Hoshiyama Y, Kikuchi S, Sakata K, et al: Family history and the risk of stomach cancer death in Japan: Differences by age and gender. Int J Cancer. 97:688–694. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Han MA, Oh MG, Choi IJ, Park SR, Ryu KW, Nam BH, Cho SJ, Kim CG, Lee JH and Kim YW: Association of family history with cancer recurrence and survival in patients with gastric cancer. J Clin Oncol. 30:701–708. 2012. View Article : Google Scholar : PubMed/NCBI

22 

van der Post RS, Vogelaar IP, Manders P, van der Kolk LE, Cats A, van Hest LP, Sijmons R, Aalfs CM, Ausems MG, Gómez Garcia EB, et al: Accuracy of hereditary diffuse gastric cancer testing criteria and outcomes in patients with a germline mutation in CDH1. Gastroenterology. 149:897–906.e19. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Feroce I, Serrano D, Biffi R, Andreoni B, Galimberti V, Sonzogni A, Bottiglieri L, Botteri E, Trovato C, Marabelli M, Marabelli M, et al: Hereditary diffuse gastric cancer in two families: A case report. Oncol Lett 14: 1671-1674, 2017.
APA
Feroce, I., Serrano, D., Biffi, R., Andreoni, B., Galimberti, V., Sonzogni, A. ... Bonanni, B. (2017). Hereditary diffuse gastric cancer in two families: A case report. Oncology Letters, 14, 1671-1674. https://doi.org/10.3892/ol.2017.6354
MLA
Feroce, I., Serrano, D., Biffi, R., Andreoni, B., Galimberti, V., Sonzogni, A., Bottiglieri, L., Botteri, E., Trovato, C., Marabelli, M., Ranzani, G. N., Bonanni, B."Hereditary diffuse gastric cancer in two families: A case report". Oncology Letters 14.2 (2017): 1671-1674.
Chicago
Feroce, I., Serrano, D., Biffi, R., Andreoni, B., Galimberti, V., Sonzogni, A., Bottiglieri, L., Botteri, E., Trovato, C., Marabelli, M., Ranzani, G. N., Bonanni, B."Hereditary diffuse gastric cancer in two families: A case report". Oncology Letters 14, no. 2 (2017): 1671-1674. https://doi.org/10.3892/ol.2017.6354
Copy and paste a formatted citation
x
Spandidos Publications style
Feroce I, Serrano D, Biffi R, Andreoni B, Galimberti V, Sonzogni A, Bottiglieri L, Botteri E, Trovato C, Marabelli M, Marabelli M, et al: Hereditary diffuse gastric cancer in two families: A case report. Oncol Lett 14: 1671-1674, 2017.
APA
Feroce, I., Serrano, D., Biffi, R., Andreoni, B., Galimberti, V., Sonzogni, A. ... Bonanni, B. (2017). Hereditary diffuse gastric cancer in two families: A case report. Oncology Letters, 14, 1671-1674. https://doi.org/10.3892/ol.2017.6354
MLA
Feroce, I., Serrano, D., Biffi, R., Andreoni, B., Galimberti, V., Sonzogni, A., Bottiglieri, L., Botteri, E., Trovato, C., Marabelli, M., Ranzani, G. N., Bonanni, B."Hereditary diffuse gastric cancer in two families: A case report". Oncology Letters 14.2 (2017): 1671-1674.
Chicago
Feroce, I., Serrano, D., Biffi, R., Andreoni, B., Galimberti, V., Sonzogni, A., Bottiglieri, L., Botteri, E., Trovato, C., Marabelli, M., Ranzani, G. N., Bonanni, B."Hereditary diffuse gastric cancer in two families: A case report". Oncology Letters 14, no. 2 (2017): 1671-1674. https://doi.org/10.3892/ol.2017.6354
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team