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Clinical application value of 3.0T MR diffusion tensor imaging in grade diagnosis of gliomas

  • Authors:
    • Wei Shan
    • Xing‑Long Wang
  • View Affiliations / Copyright

    Affiliations: Medical Image Center, The First People's Hospital of Shangqiu, Shangqiu, Henan 476100, P.R. China
    Copyright: © Shan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2009-2014
    |
    Published online on: June 13, 2017
       https://doi.org/10.3892/ol.2017.6378
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Abstract

The clinical value of MR diffusion tensor imaging (DTI) in grade diagnosis of gliomas was investigated. A total of 31 patients with glioma were administered 3.0T MR convention and DTI examination, with quantitative measurement of anisotropy coefficient fractional anisotropy (FA) and apparent dispersion coefficient (ADC) value, and the comparison of quantitative parameters of glioma between low‑ and high‑grade, which was detected by Mann‑Whitney U test. The receiver operation characteristic (ROC) curve was drawn to take the value of ADC and FA in tumor ROI as a critical point, to calculate the area under the curve and to confirm the diagnosis threshold value and evaluate its diagnostic efficiency. The FA value of 14 low‑grade glioma cases was 139.4±81.3, with an ADC value of (1.36±0.21) x10‑3 mm2/sec. The FA value of 17 high‑grade glioma cases was 103.1±41.5, with ADC value of (1.09±0.28)‑3 mm2/sec; the difference between the two groups was statistically significant (P<0.05). The ADC value was taken as the critical point to judge tumor grade and draw the ROC curve; the area under the curve was 0.79. As the diagnosis threshold value, the ADC value of 1.11x10‑3 mm2/sec was used to distinguish between low‑ and high‑grade tumor with a sensitivity of 58.8% and specificity of 92.9%. The FA value was taken as a critical point to judge tumor grade and draw the ROC curve; the area under the curve was 0.62. As the diagnosis threshold value, the FA value of 178.9 was applied to distinguish between low‑ and high‑grade tumor sensitivity of 94.1% and specificity of 35.7%. Therefore, the FA value and ADC value in DTI has an important estimated value for the pathological grade of glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Shan W and Wang XL: Clinical application value of 3.0T MR diffusion tensor imaging in grade diagnosis of gliomas. Oncol Lett 14: 2009-2014, 2017.
APA
Shan, W., & Wang, X. (2017). Clinical application value of 3.0T MR diffusion tensor imaging in grade diagnosis of gliomas. Oncology Letters, 14, 2009-2014. https://doi.org/10.3892/ol.2017.6378
MLA
Shan, W., Wang, X."Clinical application value of 3.0T MR diffusion tensor imaging in grade diagnosis of gliomas". Oncology Letters 14.2 (2017): 2009-2014.
Chicago
Shan, W., Wang, X."Clinical application value of 3.0T MR diffusion tensor imaging in grade diagnosis of gliomas". Oncology Letters 14, no. 2 (2017): 2009-2014. https://doi.org/10.3892/ol.2017.6378
Copy and paste a formatted citation
x
Spandidos Publications style
Shan W and Wang XL: Clinical application value of 3.0T MR diffusion tensor imaging in grade diagnosis of gliomas. Oncol Lett 14: 2009-2014, 2017.
APA
Shan, W., & Wang, X. (2017). Clinical application value of 3.0T MR diffusion tensor imaging in grade diagnosis of gliomas. Oncology Letters, 14, 2009-2014. https://doi.org/10.3892/ol.2017.6378
MLA
Shan, W., Wang, X."Clinical application value of 3.0T MR diffusion tensor imaging in grade diagnosis of gliomas". Oncology Letters 14.2 (2017): 2009-2014.
Chicago
Shan, W., Wang, X."Clinical application value of 3.0T MR diffusion tensor imaging in grade diagnosis of gliomas". Oncology Letters 14, no. 2 (2017): 2009-2014. https://doi.org/10.3892/ol.2017.6378
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