Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis

  • Authors:
    • Naohiro Taira
    • Tsutomu Kawabata
    • Atsushi Gabe
    • Tomonori Furugen
    • Takaharu Ichi
    • Kazuaki Kushi
    • Tomofumi Yohena
    • Hidenori Kawasaki
    • Daisuke Higuchi
    • Kenji Chibana
    • Kaori Fujita
    • Atsushi Nakamoto
    • Isoko Owan
    • Mutsuo Kuba
    • Kiyoshi Ishikawa
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, National Hospital Organization, Okinawa National Hospital, Ginowan, Okinawa 9012214, Japan, Department of General Surgery, Okinawa Prefectural Nanbu Medical Center and Children's Medical Center, Haebaru, Okinawa 9011193, Japan, Department of Gastroenterology, National Hospital Organization, Okinawa National Hospital, Ginowan, Okinawa 9012214, Japan, Department of Respiratory Medicine, National Hospital Organization, Okinawa National Hospital, Ginowan, Okinawa 9012214, Japan
  • Pages: 2399-2404
    |
    Published online on: June 14, 2017
       https://doi.org/10.3892/ol.2017.6382
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The prevalence of gastrointestinal metastasis of lung cancer is low. The aim of the present study was to analyze the frequency and clinical characteristics of metastases to the gastrointestinal tract by retrospectively assessing the clinical records of 2,066 patients with lung cancer. A total of 7 patients (0.33%) were diagnosed with gastrointestinal metastasis, including 4 patients with adenocarcinoma, 1 patient with large cell carcinoma and 2 patients with pleomorphic carcinoma. Furthermore, 3 of the patients presented with small bowel metastases, 2 with gastric metastases, 1 with large bowel metastasis and 1 with metastasis of the appendix. The mean time between the diagnosis of the lung tumors and the identification of gastrointestinal metastasis was 13.5 months (range, 3‑49 months). The mean time between the identification of the gastrointestinal metastasis and mortality was 100.6 days (range, 21‑145 days). In conclusion, the prognosis of patients with recurrence in distant organs, including the gastrointestinal tract, may be worse than patients with recurrence in distant organs, excluding the gastrointestinal tract, particularly those with symptomatic gastrointestinal metastasis. Therefore, the presence of clinical gastrointestinal metastasis may be life threatening; comprehensive evaluations are required to detect and monitor gastrointestinal metastasis during follow‑up.
View Figures

Figure 1

Figure 2

View References

1 

Auerbach O, Garfinkel L and Parks VR: Histologic type of lung cancer in relation to smoking habits, year of diagnosis and sites of metastases. Chest. 67:382–387. 1975. View Article : Google Scholar : PubMed/NCBI

2 

Hillers TK, Sauve MD and Guyatt GH: Analysis of published studies on the detection of extrathoracic metastases in patients presumed to have operable non-small cell lung cancer. Thorax. 49:14–19. 1994. View Article : Google Scholar : PubMed/NCBI

3 

McNeill PM, Wagman LD and Neifeld JP: Small bowel metastases from primary carcinoma of the lung. Cancer. 59:1486–1489. 1987. View Article : Google Scholar : PubMed/NCBI

4 

Antler AS, Ough Y, Pitchumoni CS, Davidian M and Thelmo W: Gastrointestinal metastases from malignant tumors of the lung. Cancer. 49:170–172. 1982. View Article : Google Scholar : PubMed/NCBI

5 

Yoshimoto A, Kasahara K and Kawashima A: Gastrointestinal metastases from primary lung cancer. Eur J Cancer. 42:3157–3160. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Kim SY, Ha HK, Park SW, Kang J, Kim KW, Lee SS, Park SH and Kim AY: Gastrointestinal metastasis from primary lung cancer: CT findings and clinicopathologic features. AJR Am J Roentgenol. 193:W197–W201. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Gitt SM, Flint P, Fredell CH and Schmitz GL: Bowel perforation due to metastatic lung cancer. J Surg Oncol. 51:287–291. 1992. View Article : Google Scholar : PubMed/NCBI

8 

Lee PC, Lo C, Lin MT, Liang JT and Lin BR: Role of surgical intervention in managing gastrointestinal metastases from lung cancer. World J Gastroenterol. 17:4314–4320. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Ogata R, Tanio Y, Takashima J, Kato Y, Arizumi T, Takada R, Tabata Y, Shimazu K and Fushimi H: Retrospective analysis of immediate cause of death in lung cancer-two case reports of lung cancer deaths due to bowel necrosis. Gan To Kagaku Ryoho. 38:987–990. 2011.(In Japanese). PubMed/NCBI

10 

Nichols L, Saunders R and Knollmann FD: Causes of death of patients with lung cancer. Arch Pathol Lab Med. 136:1552–1557. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta R, Postmus PE, Rusch V and Sobin L: International Association for the Study of Lung Cancer International Staging Committee; Participating Institutions: The IASLC lung cancer staging project: Proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumors. J Thorac Oncol. 2:706–714. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Leidich RB and Rudolph LE: Small bowel perforation secondary to metastatic lung carcinoma. Ann Surg. 193:67–69. 1981. View Article : Google Scholar : PubMed/NCBI

13 

Simchuk EJ and Low DE: Direct esophageal metastasis from a distant primary tumor is a submucosal process: A review of six cases. Dis Esophagus. 14:247–250. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Stenbygaard LE and Sorensen JB: Small bowel metastases in non-small cell lung cancer. Lung Cancer. 26:95–101. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Stenbygaard LE and Sørensen JB: Small bowel metastases in non-small cell lung cancer. Lung Cancer. 26:95–101. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Okazaki R, Ohtani H, Takeda K, Sumikawa T, Yamasaki A, Matsumoto S and Shimizu E: Gastric metastasis by primary lung adenocarcinoma. World J Gastrointest Oncol. 2:395–398. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Hirasaki S, Suzuki S, Umemura S, Kamei H, Okuda M and Kudo K: Asymptomatic colonic metastases from primary squamous cell carcinoma of the lung with a positive fecal occult blood test. World J Gastroenterol. 14:5481–5483. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Habeşoğlu MA, Oğuzülgen KI, Oztürk C, Akyürek N and Memiş L: A case of bronchogenic carcinoma presenting with acute abdomen. Tuberk Toraks. 53:280–283. 2005.PubMed/NCBI

19 

Carroll D and Rajesh PB: Colonic metastases from primary squamous cell carcinoma of the lung. Eur J Cardiothorac Surg. 19:719–720. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Sakai H, Egi H, Hinoi T, Tokunaga M, Kawaguchi Y, Shinomura M, Adachi T, Arihiro K and Ohdan H: Primary lung cancer presenting with metastasis to the colon: A case report. World J Surg Oncol. 10:1272012. View Article : Google Scholar : PubMed/NCBI

21 

Stinchcombe TE, Socinski MA, Gangarosa LM and Khandani AH: Lung cancer presenting with a solitary colon metastasis detected on positron emission tomography scan. J Clin Oncol. 24:4939–4940. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Yang CJ, Hwang JJ, Kang WY, Chong IW, Wang TH, Sheu CC, Tsai JR and Huang MS: Gastro-intestinal metastasis of primary lung carcinoma: Clinical presentations and outcome. Lung Cancer. 54:319–323. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Jia J, Ren J, Gu J, Di L and Song G: Predominant sarcomatoid carcinoma of the lung concurrent with jejunal metastasis and leukocytosis. Rare Tumors. 2:e442010. View Article : Google Scholar : PubMed/NCBI

24 

Byers TE, Vena JE and Rzepka TF: Predilection of lung cancer for the upper lobes: An epidemiologic inquiry. J Natl Cancer Inst. 72:1271–1275. 1984.PubMed/NCBI

25 

Coleman MP, Babb P, Mayer D, Quinn MJ and Sloggett A: Cancer survival trends in England and Wales, 1971–1995: Deprivation and NHS Region. London: Office for National Statistics; 1999

26 

Casella G, Di Bella C, Cambareri AR, Buda CA, Corti G, Magri F, Crippa S and Baldini V: Gastric metastasis by lung small cell carcinoma. World J Gastroenterol. 12:4096–4097. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Suzaki N, Hiraki A, Ueoka H, Aoe M, Takigawa N, Kishino T, Kiura K, Kanehiro A, Tanimoto M and Harada M: Gastric perforation due to metastasis from adenocarcinomaof the lung. Anticancer Res. 22:1209–1212. 2002.PubMed/NCBI

28 

Yamamoto M, Matsuzaki K, Kusumoto H, Uchida H, Mine H, Kabashima A, Maehara Y and Sugimachi K: Gastric metastasis from lung carcinoma. Case report. Hepatogastroenterology. 49:363–365. 2002.PubMed/NCBI

29 

Garwood RA, Sawyer MD, Ledesma EJ, Foley E and Claridge JA: A case and review of bowel perforation secondary to metastatic lung cancer. Am Surg. 71:110–116. 2005.PubMed/NCBI

30 

Sakorafas GH, Pavlakis G and Grigoriadis KD: Small bowel perforation secondary to metastatic lung cancer: A case report and review of the literature. Mt Sinai J Med. 70:130–132. 2003.PubMed/NCBI

31 

Atsushi G, Tsutomu K, Takao T, Hidenori K, Masayuki K and Kiyoshi S: A case report of colon metastasis from lung cancer with a long survival time. J Jpn Associat Chest Surg. 26:515–519. 2012.(In Japanese). View Article : Google Scholar

32 

Inoshita T, Youngberg GA and De Koos P Thur: Esophageal metastasis from a peripheral lung carcinoma masquerading as a primary esophageal tumor. J Surg Oncol. 24:49–52. 1983. View Article : Google Scholar : PubMed/NCBI

33 

Hsu PK, Shai SE, Wang J and Hsu CP: Esophageal metastasis from occult lung cancer. J Chin Med Assoc. 73:327–330. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Yoshino I, Yohena T, Kitajima M, Ushijima C, Nishioka K, Ichinose Y and Sugimachi K: Survival of non-small cell lung cancer patients with postoperative recurrence at distant organs. Ann Thorac Cardiovasc Surg. 7:204–209. 2001.PubMed/NCBI

35 

Lardinois D, Weder W, Roudas M, von Schulthess GK, Tutic M, Moch H, Stahel RA and Steinert HC: Etiology of solitary extrapulmonary positron emission tomography and computed tomography findings in patients with lung cancer. J Clin Oncol. 23:6846–6853. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Shiono S, Masaoka T, Sato T and Yanagawa N: Positron emission tomography (PET)-computed tomography (CT) suggesting small intestinal metastasis from lung cancer; report of a case. Kyobu Geka. 59:426–429. 2006.(In Japanese). PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Taira N, Kawabata T, Gabe A, Furugen T, Ichi T, Kushi K, Yohena T, Kawasaki H, Higuchi D, Chibana K, Chibana K, et al: Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis. Oncol Lett 14: 2399-2404, 2017.
APA
Taira, N., Kawabata, T., Gabe, A., Furugen, T., Ichi, T., Kushi, K. ... Ishikawa, K. (2017). Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis. Oncology Letters, 14, 2399-2404. https://doi.org/10.3892/ol.2017.6382
MLA
Taira, N., Kawabata, T., Gabe, A., Furugen, T., Ichi, T., Kushi, K., Yohena, T., Kawasaki, H., Higuchi, D., Chibana, K., Fujita, K., Nakamoto, A., Owan, I., Kuba, M., Ishikawa, K."Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis". Oncology Letters 14.2 (2017): 2399-2404.
Chicago
Taira, N., Kawabata, T., Gabe, A., Furugen, T., Ichi, T., Kushi, K., Yohena, T., Kawasaki, H., Higuchi, D., Chibana, K., Fujita, K., Nakamoto, A., Owan, I., Kuba, M., Ishikawa, K."Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis". Oncology Letters 14, no. 2 (2017): 2399-2404. https://doi.org/10.3892/ol.2017.6382
Copy and paste a formatted citation
x
Spandidos Publications style
Taira N, Kawabata T, Gabe A, Furugen T, Ichi T, Kushi K, Yohena T, Kawasaki H, Higuchi D, Chibana K, Chibana K, et al: Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis. Oncol Lett 14: 2399-2404, 2017.
APA
Taira, N., Kawabata, T., Gabe, A., Furugen, T., Ichi, T., Kushi, K. ... Ishikawa, K. (2017). Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis. Oncology Letters, 14, 2399-2404. https://doi.org/10.3892/ol.2017.6382
MLA
Taira, N., Kawabata, T., Gabe, A., Furugen, T., Ichi, T., Kushi, K., Yohena, T., Kawasaki, H., Higuchi, D., Chibana, K., Fujita, K., Nakamoto, A., Owan, I., Kuba, M., Ishikawa, K."Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis". Oncology Letters 14.2 (2017): 2399-2404.
Chicago
Taira, N., Kawabata, T., Gabe, A., Furugen, T., Ichi, T., Kushi, K., Yohena, T., Kawasaki, H., Higuchi, D., Chibana, K., Fujita, K., Nakamoto, A., Owan, I., Kuba, M., Ishikawa, K."Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis". Oncology Letters 14, no. 2 (2017): 2399-2404. https://doi.org/10.3892/ol.2017.6382
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team