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Article

Overexpression of long non‑coding RNA H19 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells

  • Authors:
    • Shan‑Wen Chen
    • Jing Zhu
    • Ju Ma
    • Jun‑Ling Zhang
    • Shuai Zuo
    • Guo‑Wei Chen
    • Xin Wang
    • Yi‑Sheng Pan
    • Yu‑Cun Liu
    • Peng‑Yuan Wang
  • View Affiliations / Copyright

    Affiliations: Division of General Surgery, Peking University First Hospital, Peking University, Beijing 100034, P.R. China
  • Pages: 2446-2452
    |
    Published online on: June 15, 2017
       https://doi.org/10.3892/ol.2017.6390
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Abstract

Long non‑coding RNA‑imprinted maternally expressed transcript (non‑protein coding) (H19) has been previously identified to be involved in the development of a number of types of cancer. However, the function of H19 in the pathogenesis of colorectal cancer remains unclear. The expression level of H19 in colorectal tumor tissues, and the association between H19 expression and clinicopathological variables and prognosis was investigated in the present study. In addition, the effect of H19 overexpression on viability, migration and epithelial‑mesenchymal transition (EMT) of colon cancer cells was investigated in HCT‑116 and SW‑480 cells. The results of the present study suggest that overexpression of H19 is associated with decreased recurrence‑free survival and overall survival rates in patients with colorectal cancer, and increased viability and migration in colon cancer cells. The induction of the EMT process may be an underlying molecular mechanism associated with the H19‑induced increased metastasis potential of colon cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
Chen SW, Zhu J, Ma J, Zhang JL, Zuo S, Chen GW, Wang X, Pan YS, Liu YC, Wang PY, Wang PY, et al: Overexpression of long non‑coding RNA H19 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells. Oncol Lett 14: 2446-2452, 2017.
APA
Chen, S., Zhu, J., Ma, J., Zhang, J., Zuo, S., Chen, G. ... Wang, P. (2017). Overexpression of long non‑coding RNA H19 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells. Oncology Letters, 14, 2446-2452. https://doi.org/10.3892/ol.2017.6390
MLA
Chen, S., Zhu, J., Ma, J., Zhang, J., Zuo, S., Chen, G., Wang, X., Pan, Y., Liu, Y., Wang, P."Overexpression of long non‑coding RNA H19 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells". Oncology Letters 14.2 (2017): 2446-2452.
Chicago
Chen, S., Zhu, J., Ma, J., Zhang, J., Zuo, S., Chen, G., Wang, X., Pan, Y., Liu, Y., Wang, P."Overexpression of long non‑coding RNA H19 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells". Oncology Letters 14, no. 2 (2017): 2446-2452. https://doi.org/10.3892/ol.2017.6390
Copy and paste a formatted citation
x
Spandidos Publications style
Chen SW, Zhu J, Ma J, Zhang JL, Zuo S, Chen GW, Wang X, Pan YS, Liu YC, Wang PY, Wang PY, et al: Overexpression of long non‑coding RNA H19 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells. Oncol Lett 14: 2446-2452, 2017.
APA
Chen, S., Zhu, J., Ma, J., Zhang, J., Zuo, S., Chen, G. ... Wang, P. (2017). Overexpression of long non‑coding RNA H19 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells. Oncology Letters, 14, 2446-2452. https://doi.org/10.3892/ol.2017.6390
MLA
Chen, S., Zhu, J., Ma, J., Zhang, J., Zuo, S., Chen, G., Wang, X., Pan, Y., Liu, Y., Wang, P."Overexpression of long non‑coding RNA H19 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells". Oncology Letters 14.2 (2017): 2446-2452.
Chicago
Chen, S., Zhu, J., Ma, J., Zhang, J., Zuo, S., Chen, G., Wang, X., Pan, Y., Liu, Y., Wang, P."Overexpression of long non‑coding RNA H19 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells". Oncology Letters 14, no. 2 (2017): 2446-2452. https://doi.org/10.3892/ol.2017.6390
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