Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinical relevance of Cyr61 expression in patients with hormone-dependent breast cancer

  • Authors:
    • Sebastian Mayer
    • Thalia Erbes
    • Sylvia Timme‑Bronsert
    • Markus Jaeger
    • Gerta Rücker
    • Franciska Kuf
    • Elmar Stickeler
    • Gerald Gitsch
    • Marc Hirschfeld
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Medical Center - University of Freiburg, D‑79106 Freiburg, Germany, Faculty of Medicine, University of Freiburg, D‑79106 Freiburg, Germany, Department of Gynecology and Obstetrics, University Medical Center RWTH Aachen, D‑52062 Aachen, Germany
  • Pages: 2334-2340
    |
    Published online on: June 16, 2017
       https://doi.org/10.3892/ol.2017.6406
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tumor resistance to endocrine therapy triggers estrogen‑independent cancer progression, which is a major obstacle to the successful treatment of hormone receptor positive breast cancer (BC). The underlying molecular mechanisms of endocrine resistance are not fully understood yet. The matricellular protein cysteine‑rich angiogenic inducer 61 (Cyr61) is associated with tumor invasiveness and the induction of tumorigenesis in various malignancies in vivo and the induction of estrogen‑independence and endocrine therapy resistance in BC. The present study evaluated the potential effects and clinical relevance of Cyr61 expression levels in 67 patients with primary non‑metastatic BC. Immunohistochemical analysis of formalin‑fixed paraffin‑embedded tissue sections was performed, and the association between Cyr61 protein expression and clinicopathological factors and survival was analyzed. Cyr61 overexpression was revealed to be significantly associated with a positive estrogen receptor (ER)/progesterone receptor (PR) status (P=0.016) and to the molecular subtype of BC (P=0.039). Compared with patients without Cyr61 overexpression, patients with Cyr61 overexpression exhibited an increased recurrence rate (30.6 vs. 22.6%) and decreased long‑term survival (10‑year overall survival, 62.9 vs. 69.7%); however, these associations did not reach statistically significant levels in Cox regression model analysis. Similar results were identified in the subgroup analysis of patients with ER/PR positive BC. These results indicate that Cyr61 serves a role in the development of endocrine therapy resistance in BC and is thus a potential therapeutic target to overcome endocrine therapy resistance. However, additional long‑term survival analyses with large patient populations are required.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Johnston SR and Dowsett M: Aromatase inhibitors for breast cancer: Lessons from the laboratory. Nat Rev Cancer. 3:821–831. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Massarweh S and Schiff R: Resistance to endocrine therapy in breast cancer: Exploiting estrogen receptor/growth factor signaling crosstalk. Endocr Relat Cancer. 13 Suppl 1:S15–S24. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Early Breast Cancer Trialists' Collaborative Group (EBCTCG), ; Davies C, Godwin J, Gray R, Clarke M, Cutter D, Darby S, McGale P, Pan HC, Taylor C, et al: Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: Patient-level meta-analysis of randomised trials. Lancet. 378:771–784. 2011. View Article : Google Scholar : PubMed/NCBI

4 

García-Becerra R, Santos N, Díaz L and Camacho J: Mechanisms of resistance to endocrine therapy in breast cancer: Focus on signaling pathways, miRNAs and genetically based resistance. Int J Mol Sci. 14:108–145. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Rugo HS, Vidula N and Ma C: Improving response to hormone therapy in breast cancer: New targets, new therapeutic options. Am Soc Clin Oncol Educ Book. 35:e40–e54. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Lau LF: CCN1/CYR61: The very model of a modern matricellular protein. Cell Mol Life Sci. 68:3149–3163. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Chen Y and Du XY: Functional properties and intracellular signaling of CCN1/Cyr61. J Cell Biochem. 100:1337–1345. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Katsube K, Sakamoto K, Tamamura Y and Yamaguchi A: Role of CCN, a vertebrate specific gene family, in development. Dev Growth Differ. 51:55–67. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Leask A and Abraham DJ: All in the CCN family: Essential matricellular signaling modulators emerge from the bunker. J Cell Sci. 119:4803–4810. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Lau LF and Lam SC: The CCN family of angiogenic regulators: The integrin connection. Exp Cell Res. 248:44–57. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Emre Y and Imhof BA: Matricellular protein CCN1/CYR61: A new player in inflammation and leukocyte trafficking. Semin Immunopathol. 36:253–259. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Weiskirchen R and Tacke F: Liver Fibrosis: From pathogenesis to novel therapies. Dig Dis. 34:410–422. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Xu T, He YH, Wang MQ, Yao HW, Ni MM, Zhang L, Meng XM, Huang C, Ge YX and Li J: Therapeutic potential of cysteine-rich protein 61 in rheumatoid arthritis. Gene. 592:179–185. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Li J, Ye L, Owen S, Weeks HP, Zhang Z and Jiang WG: Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review). Int J Mol Med. 36:1451–1463. 2015.PubMed/NCBI

15 

Yeger H and Perbal B: CCN family of proteins: Critical modulators of the tumor cell microenvironment. J Cell Commun Signal. 10:229–240. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Hirschfeld M, Jaeger M, Buratti E, Stuani C, Grueneisen J, Gitsch G and Stickeler E: Expression of tumor-promoting Cyr61 is regulated by hTRA2-β1 and acidosis. Hum Mol Genet. 20:2356–2365. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Hirschfeld M, zur Hausen A, Bettendorf H, Jäger M and Stickeler E: Alternative splicing of Cyr61 is regulated by hypoxia and significantly changed in breast cancer. Cancer Res. 69:2082–2090. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Sánchez-Bailón MP, Calcabrini A, Mayoral-Varo V, Molinari A, Wagner KU, Losada JP, Ciordia S, Albar JP and Martín-Pérez J: Cyr61 as mediator of Src signaling in triple negative breast cancer cells. Oncotarget. 6:13520–13538. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Sarkissyan S, Sarkissyan M, Wu Y, Cardenas J, Koeffler HP and Vadgama JV: IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion. PloS One. 9:e1035342014. View Article : Google Scholar : PubMed/NCBI

20 

Huber MC, Falkenberg N, Hauck SM, Priller M, Braselmann H, Feuchtinger A, Walch A, Schmitt M and Aubele M: Cyr61 and YB-1 are novel interacting partners of uPAR and elevate the malignancy of triple-negative breast cancer. Oncotarget. 7:44062–44075. 2016.PubMed/NCBI

21 

Jia X, Liu G, Cheng J, Shen Z and Shao Z: CYR61 contributes to poor response to letrozole in ER positive breast carcinoma. Curr Cancer Drug Targets. 2016.

22 

Lin J, Huo R, Wang L, Zhou Z, Sun Y, Shen B, Wang R and Li N: A novel anti-Cyr61 antibody inhibits breast cancer growth and metastasis in vivo. Cancer Immunol Immunother. 61:677–687. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Saglam O, Dai F, Husain S, Zhan Y, Toruner G and Haines GK III: Matricellular protein CCN1 (CYR61) expression is associated with high-grade ductal carcinoma in situ. Hum Pathol. 45:1269–1275. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Tsai MS, Bogart DF, Castañeda JM, Li P and Lupu R: Cyr61 promotes breast tumorigenesis and cancer progression. Oncogene. 21:8178–8185. 2002. View Article : Google Scholar : PubMed/NCBI

25 

The world Health Organization Histological Typing of Breast Tumors-Second Edition. The World Organization. Am J Clin Pathol. 78:806–816. 1982. View Article : Google Scholar : PubMed/NCBI

26 

Harbeck N and Rody A: Diagnostik und Therapie primärer metastasierter Mammakarzinome. http://www.ago-online.de/fileadmin/downloads/leitlinien/mamma/2017-03/AGO_deutsch/PDF_Einzeldateien_deutsch/2017D%2005_Prognostische%20und%20praediktive%20Faktoren.pdfAGO in e.V. DGGG e.V., DKG e.V.2017.

27 

Stoilov P, Daoud R, Nayler O and Stamm S: Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA. Hum Mol Genet. 13:509–524. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Schwarz G: Estimating the dimensions of a model. Ann Stat. 6:461–464. 1978. View Article : Google Scholar

29 

R Core Team, . 2016, R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/May 25–2016

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mayer S, Erbes T, Timme‑Bronsert S, Jaeger M, Rücker G, Kuf F, Stickeler E, Gitsch G and Hirschfeld M: Clinical relevance of Cyr61 expression in patients with hormone-dependent breast cancer. Oncol Lett 14: 2334-2340, 2017.
APA
Mayer, S., Erbes, T., Timme‑Bronsert, S., Jaeger, M., Rücker, G., Kuf, F. ... Hirschfeld, M. (2017). Clinical relevance of Cyr61 expression in patients with hormone-dependent breast cancer. Oncology Letters, 14, 2334-2340. https://doi.org/10.3892/ol.2017.6406
MLA
Mayer, S., Erbes, T., Timme‑Bronsert, S., Jaeger, M., Rücker, G., Kuf, F., Stickeler, E., Gitsch, G., Hirschfeld, M."Clinical relevance of Cyr61 expression in patients with hormone-dependent breast cancer". Oncology Letters 14.2 (2017): 2334-2340.
Chicago
Mayer, S., Erbes, T., Timme‑Bronsert, S., Jaeger, M., Rücker, G., Kuf, F., Stickeler, E., Gitsch, G., Hirschfeld, M."Clinical relevance of Cyr61 expression in patients with hormone-dependent breast cancer". Oncology Letters 14, no. 2 (2017): 2334-2340. https://doi.org/10.3892/ol.2017.6406
Copy and paste a formatted citation
x
Spandidos Publications style
Mayer S, Erbes T, Timme‑Bronsert S, Jaeger M, Rücker G, Kuf F, Stickeler E, Gitsch G and Hirschfeld M: Clinical relevance of Cyr61 expression in patients with hormone-dependent breast cancer. Oncol Lett 14: 2334-2340, 2017.
APA
Mayer, S., Erbes, T., Timme‑Bronsert, S., Jaeger, M., Rücker, G., Kuf, F. ... Hirschfeld, M. (2017). Clinical relevance of Cyr61 expression in patients with hormone-dependent breast cancer. Oncology Letters, 14, 2334-2340. https://doi.org/10.3892/ol.2017.6406
MLA
Mayer, S., Erbes, T., Timme‑Bronsert, S., Jaeger, M., Rücker, G., Kuf, F., Stickeler, E., Gitsch, G., Hirschfeld, M."Clinical relevance of Cyr61 expression in patients with hormone-dependent breast cancer". Oncology Letters 14.2 (2017): 2334-2340.
Chicago
Mayer, S., Erbes, T., Timme‑Bronsert, S., Jaeger, M., Rücker, G., Kuf, F., Stickeler, E., Gitsch, G., Hirschfeld, M."Clinical relevance of Cyr61 expression in patients with hormone-dependent breast cancer". Oncology Letters 14, no. 2 (2017): 2334-2340. https://doi.org/10.3892/ol.2017.6406
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team