Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2017 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma

  • Authors:
    • Ying‑Fen Hong
    • Zhan‑Hong Chen
    • Li Wei
    • Xiao‑Kun Ma
    • Xing Li
    • Jing‑Yun Wen
    • Tian‑Tian Wang
    • Xiu‑Rong Cai
    • Dong‑Hao Wu
    • Jie Chen
    • Dan‑Yun Ruan
    • Ze‑Xiao Lin
    • Qu Lin
    • Min Dong
    • Xiang‑Yuan Wu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Giangdong 510630, P.R. China
    Copyright: © Hong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2089-2096
    |
    Published online on: June 19, 2017
       https://doi.org/10.3892/ol.2017.6420
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The inflammatory microenvironment serves an important function in the progression of hepatocellular carcinoma (HCC). Peripheral blood lymphocyte-to-monocyte ratio (LMR), as a novel inflammatory biomarker combining an estimate of host immune homeostasis with the tumor microenvironment, has been identified to be a predictor of clinical outcomes in a number of malignancies. The present study aimed at investigating the prognostic value of LMR in patients with hepatitis B virus (HBV)-associated advanced HCC. A total of 174 patients with HBV‑associated advanced HCC, without fever or signs of infections, were analyzed. Clinicopathological parameters, including LMR, were eva­luated to identify predictors of overall survival time. Univariate and multivariate analysis was performed using Cox's proportional hazards model. A threshold value was determined using a time‑dependent receiver operating characteristic curve. Univariate and multivariate analysis identified LMR as an independent prognostic factor in overall survival (OS) time in patients with HBV‑associated advanced HCC (P<0.05). The threshold value of LMR was 2.22. All patients were divided into either a low LMR group (≤2.22) or a high LMR group (>2.22). The OS time of the high LMR group was significantly longer compared with the low LMR group (P<0.001). Patients in the high LMR group exhibited a significantly increased 3‑month and 6‑month OS rate, compared with that of the patients within the low LMR group (P<0.001). An increased level of LMR was significantly associated with the presence of metastasis, ascites and increased tumor size (P<0.01). LMR is an independent prognostic factor of HBV‑associated advanced HCC patients and an increased baseline LMR level indicates an improved prognosis.
View Figures

Figure 1

Figure 2

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Yuan JM, Govindarajan S, Arakawa K and Yu MC: Synergism of alcohol, diabetes and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S. Cancer. 101:1009–1017. 2014. View Article : Google Scholar

4 

Bruix J and Sherman M: Practice Guidelines Committee, American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma. Hepatology. 42:1208–1236. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Li J, Wang L, Cong N, Shi C, Bu W, Song J and Chen H: Efficacy of sorafenib for advanced hepatocellular carcinoma and prognostic factors. Hepatogastroenterology. 61:954–957. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Ogasawara S, Chiba T, Ooka Y, Suzuki E, Kanogawa N, Saito T, Motoyama T, Tawada A, Kanai F and Yokosuka O: Post-progression survival in patients with advanced hepatocellular carcinoma resistant to sorafenib. Invest New Drugs. 34:255–260. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Hong YF, Chen ZH, Ma XK, Li X, Wu DH, Chen J, Dong M, Wei L, Wang TT, Ruan DY, et al: Comparison of five models for end-stage liver disease in predicting the survival rate of patients with advanced hepatocellular carcinoma. Tumour Biol. 37:5265–5273. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Sherman M: Hepatocellular carcinoma: Epidemiology, surveillance, and diagnosis. Semin Liver Dis. 30:3–16. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Bugada D, Allegri M, Lavand'homme P, De Kock M and Fanelli G: Inflammation-based scores: A new method for patient-targeted strategies and improved perioperative outcome in cancer patients. Biomed Res Int. 2014:1424252014. View Article : Google Scholar : PubMed/NCBI

10 

Deng Q, He B, Liu X, Yue J, Ying H, Pan Y, Sun H, Chen J, Wang F, Gao T, et al: Prognostic value of pre-operative inflammatory response biomarkers in gastric cancer patients and the construction of a predictive model. J Transl Med. 13:662015. View Article : Google Scholar : PubMed/NCBI

11 

Shiels MS, Katki HA, Hildesheim A, Pfeiffer RM, Engels EA, Williams M, Kemp TJ, Caporaso NE, Pinto LA and Chaturvedi AK: Circulating inflammation markers, risk of lung cancer, and utility for risk stratification. J Natl Cancer Inst. 107:djv1992015. View Article : Google Scholar : PubMed/NCBI

12 

Morrison L, Laukkanen JA, Ronkainen K, Kurl S, Kauhanen J and Toriola AT: Inflammatory biomarker score and cancer: A population-based prospective cohort study. BMC Cancer. 16:802016. View Article : Google Scholar : PubMed/NCBI

13 

Fang S, Wang Y, Sui D, Liu H, Ross MI, Gershenwald JE, Cormier JN, Royal RE, Lucci A, Schacherer CW, et al: C-reactive protein as a marker of melanoma progression. J Clin Oncol. 33:1389–1396. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Aleksandrova K, Boeing H, Nöthlings U, Jenab M, Fedirko V, Kaaks R, Lukanova A, Trichopoulou A, Trichopoulos D, Boffetta P, et al: Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer. Hepatology. 60:858–871. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Schumacher D, Strilic B, Sivaraj KK, Wettschureck N and Offermanns S: Platelet-derived nucleotides promote tumor-cell transendothelialmigration and metastasis via p2y2 receptor. Cancer Cell. 24:130–137. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Grosse-Steffen T, Giese T, Giese N, Longerich T, Schirmacher P, Hansch GM and Gaida MM: Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma and pancreatic tumor cell lines: The role of neutrophils and neutrophil-derived elastase. Clin Dev Immunol. 2012:7207682012. View Article : Google Scholar : PubMed/NCBI

17 

Ren QQ, Fu SJ, Zhao Q, Guo ZY, Ji F, Chen MG, Wu LW and He XS: Prognostic value of preoperative peripheral monocyte count in patients with hepatocellular carcinoma after liver transplantation. Tumor Biol. 37:8973–8988. 2016. View Article : Google Scholar

18 

Jia W, Wu J, Jia H, Yang Y, Zhang X, Chen K and Su F: The peripheral blood Neutrophil-to-Lymphocyte ratio is superior to the Lymphocyte-to-Monocyte ratio for predicting the long-term survival of triple-negative breast cancer patients. PLoS One. 10:e01430612015. View Article : Google Scholar : PubMed/NCBI

19 

Chang Y, Fu Q, Xu L, Zhou L, Liu Z, Yang Y, Lin Z and Xu J: Prognostic value of preoperative lymphocyte to monocyte ratio in patients with nonmetastatic clear cell renal cell carcinoma. Tumor Biol. 37:4613–4620. 2016. View Article : Google Scholar

20 

Chang Y, An H, Xu L, Zhu Y, Yang Y, Lin Z and Xu J: Systemic inflammation score predicts postoperative prognosis of patients with clear-cell renal cell carcinoma. Br J Cancer. 113:626–633. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Chen YM, Lai CH, Chang HC, Chao TY, Tseng CC, Fang WF, Wang CC, Chung YH, Wang YH, Su MC, et al: Baseline and trend of Lymphocyte-to-Monocyte ratio as prognostic factors in epidermal growth factor receptor mutant non-small cell lung cancer patients treated with first-line epidermal growth factor tyrosine kinase inhibitors. PLoS One. 10:e01362522015. View Article : Google Scholar : PubMed/NCBI

22 

Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, et al: Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer. World J Gastroenterol. 21:9966–9973. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Lin ZX, Ruan DY, Li Y, Wu DH, Ma XK, Chen J, Chen ZH, Li X, Wang TT, Lin Q, et al: Lymphocyte-to-monocyte ratio predicts survival of patients with hepatocellular carcinoma after curative resection. World J Gastroenterol. 21:10898–10906. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Llovet JM, Brú C and Bruix J: Prognosis of hepatocellular carcinoma: The BCLC staging classification. Semin Liver Dis. 19:329–338. 1999. View Article : Google Scholar : PubMed/NCBI

25 

National Comprehensive Cancer Network. NCCN Guidelines Version 2.2105 Hepatocellular Carcinoma.

26 

Schag CC, Heinrich RL and Ganz PA: Karnofsky performance status revisited: Reliability, validity, and guidelines. J Clin Oncol. 2:187–193. 1984. View Article : Google Scholar : PubMed/NCBI

27 

Fluss R, Faraggi D and Reiser B: Estimation of the Youden Index and its associated cutoff point. Biom J. 47:458–472. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Keibel A, Singh V and Sharma MC: Inflammation, microenvironment, and the immune system in cancer progression. Curr Pharm Des. 15:1949–1955. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Balkwill F and Mantovani A: Inflammation and cancer: Back to Virchow? Lancet. 357:539–545. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Mantovani A, Allavena P, Sica A and Balkwill F: Cancer-related inflammation. Nature. 454:436–444. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Wang Y, Niu XL, Qu Y, Wu J, Zhu YQ, Sun WJ and Li LZ: Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells. Cancer Lett. 295:110–123. 2015. View Article : Google Scholar

32 

Kuang DM, Zhao Q, Wu Y, Peng C, Wang J, Xu Z, Yin XY and Zheng L: Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J Hepatol. 54:948–955. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Lee IK, Vansaun MN, Shim JH, Matrisian LM and Gorden DL: Increased metastases are associated with inflammation and matrix metalloproteinase-9 activity at incision sites in a murine model of peritoneal dissemination of colorectal cancer. J Surg Res. 180:252–259. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Mishalian I, Granot Z and Fridlender ZG: The diversity of circulating neutrophils in cancer. Immunobiology. 222:82–88. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Dunn GP, Old LJ and Schreiber RD: The immunobiology of cancer immunosurveillance and immunoediting. Immunity. 21:137–148. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Condeelis J and Pollard JW: Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis. Cell. 124:263–266. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Leek RD and Harris AL: Tumor-associated macrophages in breast cancer. J Mammary Gland Biol Neoplasia. 7:177–189. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Gay LJ and Felding-Habermann B: Contribution of platelets to tumour metastasis. Nat Rev Cancer. 11:123–134. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Buergy D, Wenz F, Groden C and Brockmann MA: Tumor-platelet interaction in solid tumors. Int J Cancer. 130:2747–2760. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Chen XF, Qian J, Pei D, Zhou C, Røe OD, Zhu F, He SH, Qian YY, Zhou Y, Xu J, et al: Prognostic value of perioperative leukocyte count in resectable gastric cancer. World J Gastroenterol. 22:2818–2827. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Kitayama J, Yasuda K, Kawai K, Sunami E and Nagawa H: Circulating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancer. Radiat Oncol. 5:472010. View Article : Google Scholar : PubMed/NCBI

42 

Gu L, Li H, Chen L, Ma X, Li X, Gao Y, Zhang Y, Xie Y and Zhang X: Prognostic role of lymphocyte to monocyte ratio for patients with cancer: Evidence from a systematic review and meta-analysis. Oncotarget. 7:31926–31942. 2016.PubMed/NCBI

43 

Hoffmann TK, Dworacki G, Tsukihiro T, Meidenbauer N, Gooding W, Johnson JT and Whiteside TL: Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance. Clin Cancer Res. 8:2553–2562. 2002.PubMed/NCBI

44 

Rabinowich H, Cohen R, Bruderman I, Steiner Z and Klajman A: Functional analysis of mononuclear cells infiltrating into tumors: Lysis of autologous human tumor cells by cultured infiltrating lymphocytes. Cancer Res. 47:173–177. 1987.PubMed/NCBI

45 

Stotz M, Pichler M, Absenger G, Szkandera J, Arminger F, Schaberl-Moser R, Samonigg H, Stojakovic T and Gerger A: The preoperative lymphocyte to monocyte ratio predicts clinical outcome in patients with stage III colon cancer. Br J Cancer. 110:435–440. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Unitt E, Marshall A, Gelson W, Rushbrook SM, Davies S, Vowler SL, Morris LS, Coleman N and Alexander GJ: Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation. J Hepatol. 45:246–253. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Zikos TA, Donnenberg AD, Landreneau RJ, Luketich JD and Donnenberg VS: Lung T-cell subset composition at the time of surgical resection is a prognostic indicator in nonsmall cell lung cancer. Cancer Immunol Immunother. 60:819–827. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Gao Q, Qiu SJ, Fan J, Zhou J, Wang XY, Xiao YS, Xu Y, Li YW and Tang ZY: Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol. 25:2586–2593. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Evani SJ, Prabhu RG, Gnanaruban V, Finol EA and Ramasubramanian AK: Monocytes mediate metastatic breast tumor cell adhesion to endothelium under flow. FASEB J. 27:3017–3029. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Shi C and Pamer EG: Monocyte recruitment during infection and inflammation. Nat Rev Immunol. 11:762–774. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Pollard JW: Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer. 4:71–78. 2004. View Article : Google Scholar : PubMed/NCBI

52 

Hagemann T and Lawrence T: Investigating macrophage and malign interactions in vitro. Methods Mol Biol. 512:325–332. 2009. View Article : Google Scholar : PubMed/NCBI

53 

Tadmor T: Does monocyte count have prognostic significance in cancer? Leuk Res. 37:1193–1194. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Sasaki A, Iwashita Y, Shibata K, Matsumoto T, Ohta M and Kitano S: Prognostic value of preoperative peripheral blood monocyte count inpatients with hepatocellular carcinoma. Surgery. 139:755–764. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Lin GN, Jiang XM, Peng JW, Xiao JJ, Liu DY and Xia ZJ: Prognostic significance of the peripheral blood absolute monocyte count inpatients with locally advanced or metastatic hepatocellular carcinoma receiving systemic chemotherapy. Asian Pac J Cancer Prev. 15:6387–6390. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Zhang J, Feng G, Zhao Y, Zhang J, Feng L and Yang J: Association between lymphocyte-to-monocyte ratio (LMR) and the mortality of HBV-related liver cirrhosis: A retrospective cohort study. BMJ Open. 5:e0080332015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hong YF, Chen ZH, Wei L, Ma XK, Li X, Wen JY, Wang TT, Cai XR, Wu DH, Chen J, Chen J, et al: Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma. Oncol Lett 14: 2089-2096, 2017.
APA
Hong, Y., Chen, Z., Wei, L., Ma, X., Li, X., Wen, J. ... Wu, X. (2017). Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma. Oncology Letters, 14, 2089-2096. https://doi.org/10.3892/ol.2017.6420
MLA
Hong, Y., Chen, Z., Wei, L., Ma, X., Li, X., Wen, J., Wang, T., Cai, X., Wu, D., Chen, J., Ruan, D., Lin, Z., Lin, Q., Dong, M., Wu, X."Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma". Oncology Letters 14.2 (2017): 2089-2096.
Chicago
Hong, Y., Chen, Z., Wei, L., Ma, X., Li, X., Wen, J., Wang, T., Cai, X., Wu, D., Chen, J., Ruan, D., Lin, Z., Lin, Q., Dong, M., Wu, X."Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma". Oncology Letters 14, no. 2 (2017): 2089-2096. https://doi.org/10.3892/ol.2017.6420
Copy and paste a formatted citation
x
Spandidos Publications style
Hong YF, Chen ZH, Wei L, Ma XK, Li X, Wen JY, Wang TT, Cai XR, Wu DH, Chen J, Chen J, et al: Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma. Oncol Lett 14: 2089-2096, 2017.
APA
Hong, Y., Chen, Z., Wei, L., Ma, X., Li, X., Wen, J. ... Wu, X. (2017). Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma. Oncology Letters, 14, 2089-2096. https://doi.org/10.3892/ol.2017.6420
MLA
Hong, Y., Chen, Z., Wei, L., Ma, X., Li, X., Wen, J., Wang, T., Cai, X., Wu, D., Chen, J., Ruan, D., Lin, Z., Lin, Q., Dong, M., Wu, X."Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma". Oncology Letters 14.2 (2017): 2089-2096.
Chicago
Hong, Y., Chen, Z., Wei, L., Ma, X., Li, X., Wen, J., Wang, T., Cai, X., Wu, D., Chen, J., Ruan, D., Lin, Z., Lin, Q., Dong, M., Wu, X."Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma". Oncology Letters 14, no. 2 (2017): 2089-2096. https://doi.org/10.3892/ol.2017.6420
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team