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Article

Clinicopathological significance of glucose transporter protein-1 overexpression in human osteosarcoma

  • Authors:
    • Jian Fan
    • Jiong Mei
    • Ming‑Zhu Zhang
    • Feng Yuan
    • Shan‑Zhu Li
    • Guang‑Rong Yu
    • Long‑Hui Chen
    • Qian Tang
    • Cory J. Xian
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Tongji Hospital, Tongji University, Shanghai 200065, P.R. China, Pi‑wei Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, P.R. China, Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia 5001, Australia
  • Pages: 2439-2445
    |
    Published online on: June 21, 2017
       https://doi.org/10.3892/ol.2017.6437
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Abstract

Although previous studies have demonstrated that Glut‑1 is the predominant glucose transporter, is significantly overexpressed in various types of tumor and is correlated with poor prognosis, the potential function and clinical value of Glut‑1 expression in osteosarcoma remains largely unclear. In particular, the prospective associations between Glut‑1 expression levels and clinicopathological factors remains to be elucidated. In the present study, immunohistochemistry was performed to detect Glut‑1 protein expression in 51 paired osteosarcoma specimens and adjacent non‑cancerous tissues, and reverse transcription‑quantitative polymerase chain reaction analysis was performed to examine Glut‑1 mRNA expression levels in 6 pairs of these tissues. Statistical analyses were conducted to determine the associations between Glut‑1 expression and various clinicopathological parameters. Glut‑1 protein was revealed to be overexpressed in 38 (74.5%) osteosarcoma tissues, but only in 6 (11.8%) adjacent non‑cancerous tissues. Glut‑1 mRNA levels were also upregulated in osteosarcoma tissues compared with adjacent non‑cancerous tissues. While there were no clear statistical relationships between Glut‑1 expression and patient sex, resection, tumor location, size, T stage and adjuvant treatment, Glut‑1 expression levels were significantly associated with age, tumor‑node‑metastasis stage, lymph node metastasis and survival. The median survival time in patients with low Glut‑1 expression levels was longer than in patients with a high expression level. Glut‑1 was significantly overexpressed in osteosarcoma tissues, and Glut‑1 expression was associated with clinicopathological factors which upregulate the invasion and metastasis of osteosarcoma, and may be a potential predictor of survival in patients with osteosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Fan J, Mei J, Zhang MZ, Yuan F, Li SZ, Yu GR, Chen LH, Tang Q and Xian CJ: Clinicopathological significance of glucose transporter protein-1 overexpression in human osteosarcoma. Oncol Lett 14: 2439-2445, 2017.
APA
Fan, J., Mei, J., Zhang, M., Yuan, F., Li, S., Yu, G. ... Xian, C.J. (2017). Clinicopathological significance of glucose transporter protein-1 overexpression in human osteosarcoma. Oncology Letters, 14, 2439-2445. https://doi.org/10.3892/ol.2017.6437
MLA
Fan, J., Mei, J., Zhang, M., Yuan, F., Li, S., Yu, G., Chen, L., Tang, Q., Xian, C. J."Clinicopathological significance of glucose transporter protein-1 overexpression in human osteosarcoma". Oncology Letters 14.2 (2017): 2439-2445.
Chicago
Fan, J., Mei, J., Zhang, M., Yuan, F., Li, S., Yu, G., Chen, L., Tang, Q., Xian, C. J."Clinicopathological significance of glucose transporter protein-1 overexpression in human osteosarcoma". Oncology Letters 14, no. 2 (2017): 2439-2445. https://doi.org/10.3892/ol.2017.6437
Copy and paste a formatted citation
x
Spandidos Publications style
Fan J, Mei J, Zhang MZ, Yuan F, Li SZ, Yu GR, Chen LH, Tang Q and Xian CJ: Clinicopathological significance of glucose transporter protein-1 overexpression in human osteosarcoma. Oncol Lett 14: 2439-2445, 2017.
APA
Fan, J., Mei, J., Zhang, M., Yuan, F., Li, S., Yu, G. ... Xian, C.J. (2017). Clinicopathological significance of glucose transporter protein-1 overexpression in human osteosarcoma. Oncology Letters, 14, 2439-2445. https://doi.org/10.3892/ol.2017.6437
MLA
Fan, J., Mei, J., Zhang, M., Yuan, F., Li, S., Yu, G., Chen, L., Tang, Q., Xian, C. J."Clinicopathological significance of glucose transporter protein-1 overexpression in human osteosarcoma". Oncology Letters 14.2 (2017): 2439-2445.
Chicago
Fan, J., Mei, J., Zhang, M., Yuan, F., Li, S., Yu, G., Chen, L., Tang, Q., Xian, C. J."Clinicopathological significance of glucose transporter protein-1 overexpression in human osteosarcoma". Oncology Letters 14, no. 2 (2017): 2439-2445. https://doi.org/10.3892/ol.2017.6437
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