MicroRNA‑433 regulates apoptosis by targeting PDCD4 in human osteosarcoma cells

  • Authors:
    • Yinghua Sun
    • Fuchao Wang
    • Li Wang
    • Zhaode Jiao
    • Jun Fang
    • Jianmin Li
  • View Affiliations

  • Published online on: June 21, 2017     https://doi.org/10.3892/ol.2017.6441
  • Pages: 2353-2358
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Abstract

Osteosarcoma is the most common aggressive sarcoma of the bone in children and adolescents. It is characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. microRNAs (miRNAs) play a key role in cancer initiation, progression and metastasis; however, the potential role of miRNAs in osteosarcoma remains largely unknown. In the present study, miR‑433 was shown to be overexpressed in osteosarcoma tissues compared with normal human osteoblasts. Transfection of miR‑433 mimics into osteosarcoma cell lines significantly decreased apoptosis by targeting programmed cell death 4, a tumor suppressor that is involved in apoptosis. In contrast, inhibition of miR‑433 enhanced apoptosis. Furthermore, in vivo miR‑433 overexpression inhibited the apoptosis of tumor cells and increased tumor growth. The results of the present study suggested that miR‑433 is a potential molecular target for osteosarcoma therapy.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Sun Y, Wang F, Wang L, Jiao Z, Fang J and Li J: MicroRNA‑433 regulates apoptosis by targeting PDCD4 in human osteosarcoma cells. Oncol Lett 14: 2353-2358, 2017.
APA
Sun, Y., Wang, F., Wang, L., Jiao, Z., Fang, J., & Li, J. (2017). MicroRNA‑433 regulates apoptosis by targeting PDCD4 in human osteosarcoma cells. Oncology Letters, 14, 2353-2358. https://doi.org/10.3892/ol.2017.6441
MLA
Sun, Y., Wang, F., Wang, L., Jiao, Z., Fang, J., Li, J."MicroRNA‑433 regulates apoptosis by targeting PDCD4 in human osteosarcoma cells". Oncology Letters 14.2 (2017): 2353-2358.
Chicago
Sun, Y., Wang, F., Wang, L., Jiao, Z., Fang, J., Li, J."MicroRNA‑433 regulates apoptosis by targeting PDCD4 in human osteosarcoma cells". Oncology Letters 14, no. 2 (2017): 2353-2358. https://doi.org/10.3892/ol.2017.6441