Open Access

MicroRNA‑34a suppresses colorectal cancer metastasis by regulating Notch signaling

  • Authors:
    • Xuemei Zhang
    • Feiyan Ai
    • Xiayu Li
    • Li Tian
    • Xiaoyan Wang
    • Shourong Shen
    • Fen Liu
  • View Affiliations

  • Published online on: June 21, 2017     https://doi.org/10.3892/ol.2017.6444
  • Pages: 2325-2333
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dysregulation of microRNA (miRNA/miR) expression is causally associated with cancer initiation and progression. However, the precise mechanisms by which dysregulated miRNAs induce colorectal tumorigenesis remain unknown. In the present study, downregulation of miR‑34a was identified in colorectal cancer cell lines and clinical specimens. Clinical studies revealed that miR‑34a expression was negatively associated with distant metastasis, and positively associated with differentiation and survival of human colorectal cancer specimens. In vitro miRNA functional assays demonstrated that miR‑34a bound to the putative 3'‑untranslated regions of Notch1 and Jagged1 in SW480 cells, and thereby attenuated the migration and invasion of the colon cancer cells. It was additionally identified that miR‑34a downregulated the expression of vimentin and fibronectin via Notch1 and Jagged1. Overall, these data indicate that miR‑34a serves a key role in suppressing colorectal cancer metastasis by targeting and regulating Notch signaling.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang X, Ai F, Li X, Tian L, Wang X, Shen S and Liu F: MicroRNA‑34a suppresses colorectal cancer metastasis by regulating Notch signaling. Oncol Lett 14: 2325-2333, 2017
APA
Zhang, X., Ai, F., Li, X., Tian, L., Wang, X., Shen, S., & Liu, F. (2017). MicroRNA‑34a suppresses colorectal cancer metastasis by regulating Notch signaling. Oncology Letters, 14, 2325-2333. https://doi.org/10.3892/ol.2017.6444
MLA
Zhang, X., Ai, F., Li, X., Tian, L., Wang, X., Shen, S., Liu, F."MicroRNA‑34a suppresses colorectal cancer metastasis by regulating Notch signaling". Oncology Letters 14.2 (2017): 2325-2333.
Chicago
Zhang, X., Ai, F., Li, X., Tian, L., Wang, X., Shen, S., Liu, F."MicroRNA‑34a suppresses colorectal cancer metastasis by regulating Notch signaling". Oncology Letters 14, no. 2 (2017): 2325-2333. https://doi.org/10.3892/ol.2017.6444