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Voltage-gated calcium channels: Novel targets for cancer therapy

  • Authors:
    • Nam Nhut Phan
    • Chih‑Yang Wang
    • Chien‑Fu Chen
    • Zhengda Sun
    • Ming‑Derg Lai
    • Yen‑Chang Lin
  • View Affiliations / Copyright

    Affiliations: Faculty of Applied Sciences, Ton Duc Thang University, Tan Phong Ward, Ho Chi Minh 700000, Vietnam, Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, R.O.C., School of Chinese Medicine for Post‑Baccalaureate, I‑Shou University, Kaohsiung 84001, Taiwan, R.O.C., Department of Radiology, University of California, San Francisco, CA 94143, USA, Graduate Institute of Biotechnology, Chinese Culture University, Taipei 1114, Taiwan, R.O.C.
    Copyright: © Phan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2059-2074
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    Published online on: June 22, 2017
       https://doi.org/10.3892/ol.2017.6457
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Abstract

Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L‑type; R‑type; N‑type; P/Q‑type; and T‑type, which are encoded by α1 subunit genes. Calcium ion channels also have confirmed roles in cellular functions, including mitogenesis, proliferation, differentiation, apoptosis and metastasis. An association between VGCCs, a reduction in proliferation and an increase in apoptosis in prostate cancer cells has also been reported. Therefore, in the present study, the online clinical database Oncomine was used to identify the alterations in the mRNA expression level of VGCCs in 19 cancer subtypes. Overall, VGCC family genes exhibited under‑expression in numerous types of cancer, including brain, breast, kidney and lung cancers. Notably, the majority of VGCC family members (CACNA1C, CACNA1D, CACNA1A, CACNA1B, CACNA1E, CACNA1H and CACNA1I) exhibited low expression in brain tumors, with mRNA expression levels in the top 1‑9% of downregulated gene rankings. A total of 5 VGCC family members (CACNA1A, CACNA1B, CACNA1E, CACNA1G and CACNA1I) were under‑expressed in breast cancer, with a gene ranking in the top 1‑10% of the low‑expressed genes compared with normal tissue. In kidney and lung cancers, CACNA1S, CACNA1C, CACNA1D, CACNA1A and CACNA1H exhibited low expression, with gene rankings in the top 1‑8% of downregulated genes. In conclusion, the present findings may contribute to the development of new cancer treatment approaches by identifying target genes involved in specific types of cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Phan NN, Wang CY, Chen CF, Sun Z, Lai MD and Lin YC: Voltage-gated calcium channels: Novel targets for cancer therapy. Oncol Lett 14: 2059-2074, 2017.
APA
Phan, N.N., Wang, C., Chen, C., Sun, Z., Lai, M., & Lin, Y. (2017). Voltage-gated calcium channels: Novel targets for cancer therapy. Oncology Letters, 14, 2059-2074. https://doi.org/10.3892/ol.2017.6457
MLA
Phan, N. N., Wang, C., Chen, C., Sun, Z., Lai, M., Lin, Y."Voltage-gated calcium channels: Novel targets for cancer therapy". Oncology Letters 14.2 (2017): 2059-2074.
Chicago
Phan, N. N., Wang, C., Chen, C., Sun, Z., Lai, M., Lin, Y."Voltage-gated calcium channels: Novel targets for cancer therapy". Oncology Letters 14, no. 2 (2017): 2059-2074. https://doi.org/10.3892/ol.2017.6457
Copy and paste a formatted citation
x
Spandidos Publications style
Phan NN, Wang CY, Chen CF, Sun Z, Lai MD and Lin YC: Voltage-gated calcium channels: Novel targets for cancer therapy. Oncol Lett 14: 2059-2074, 2017.
APA
Phan, N.N., Wang, C., Chen, C., Sun, Z., Lai, M., & Lin, Y. (2017). Voltage-gated calcium channels: Novel targets for cancer therapy. Oncology Letters, 14, 2059-2074. https://doi.org/10.3892/ol.2017.6457
MLA
Phan, N. N., Wang, C., Chen, C., Sun, Z., Lai, M., Lin, Y."Voltage-gated calcium channels: Novel targets for cancer therapy". Oncology Letters 14.2 (2017): 2059-2074.
Chicago
Phan, N. N., Wang, C., Chen, C., Sun, Z., Lai, M., Lin, Y."Voltage-gated calcium channels: Novel targets for cancer therapy". Oncology Letters 14, no. 2 (2017): 2059-2074. https://doi.org/10.3892/ol.2017.6457
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