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Article Open Access

TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis

  • Authors:
    • Ling Hao
    • Boyu Du
    • Xueyan Xi
  • View Affiliations / Copyright

    Affiliations: School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
    Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2153-2164
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    Published online on: June 22, 2017
       https://doi.org/10.3892/ol.2017.6467
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Abstract

Lung cancer is the leading cause of cancer-associated mortality worldwide and its prognosis is poor. Few effective biomarkers for non‑small cell lung cancer (NSCLC) have been translated into the clinical practice aiming to assist in the treatment plan design and prognosis evaluation. The aim of the present study was to identify novel potential prognostic biomarkers for NSCLC. Tripartite motif 59 (TRIM59) was identified from a microarray dataset of matched‑samples and was verified as an aberrantly upregulated gene in NSCLC tissue. The expression level of TRIM59 in NSCLC subtypes was observed to be significantly increased in large cell lung carcinoma and squamous cell carcinoma as compared with that in adenocarcinoma. Its expression correlated with several clinicopathological features, including gender, smoking habits, and unfavorable tumor node and pathological stages. Notably, TRIM59 demonstrated a negative correlation with survival time and its overexpression indicated a poor prognosis in NSCLC. Furthermore, univariate and multivariate Cox's regression analyses indicated that TRIM59 was an independent prognostic factor in tumor tissue as compared with age, gender, tumor stage, node stage, and metastasis. Gene set enrichment analysis and protein‑protein interaction network construction revealed that TRIM59 was associated with oncogenic mammalian target of rapamycin (MTOR) and eukaryotic initiation factor 4E (EIF4E) signaling through ubiquitin C binding. In conclusion, it was revealed that TRIM59 is a novel prognostic biomarker modulating oncogenic MTOR and EIF4E signaling pathways in NSCLC. These findings provided a novel insight into the clinical application of TRIM59. Therefore, TRIM59 may serve as an independent predictor for prognosis and a potential therapeutic target for NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Hao L, Du B and Xi X: TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis. Oncol Lett 14: 2153-2164, 2017.
APA
Hao, L., Du, B., & Xi, X. (2017). TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis. Oncology Letters, 14, 2153-2164. https://doi.org/10.3892/ol.2017.6467
MLA
Hao, L., Du, B., Xi, X."TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis". Oncology Letters 14.2 (2017): 2153-2164.
Chicago
Hao, L., Du, B., Xi, X."TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis". Oncology Letters 14, no. 2 (2017): 2153-2164. https://doi.org/10.3892/ol.2017.6467
Copy and paste a formatted citation
x
Spandidos Publications style
Hao L, Du B and Xi X: TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis. Oncol Lett 14: 2153-2164, 2017.
APA
Hao, L., Du, B., & Xi, X. (2017). TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis. Oncology Letters, 14, 2153-2164. https://doi.org/10.3892/ol.2017.6467
MLA
Hao, L., Du, B., Xi, X."TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis". Oncology Letters 14.2 (2017): 2153-2164.
Chicago
Hao, L., Du, B., Xi, X."TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis". Oncology Letters 14, no. 2 (2017): 2153-2164. https://doi.org/10.3892/ol.2017.6467
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