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Article Open Access

Independent prognostic miRNAs for bladder urothelial carcinoma

  • Authors:
    • Yingbo Hu
    • Cheng Cheng
    • Zhengdong Hong
    • Ziming Shi
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3001-3005
    |
    Published online on: June 23, 2017
       https://doi.org/10.3892/ol.2017.6471
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Abstract

Bladder cancer is the most common malignant tumor of the urinary system, and it is also an important cause of death by cancer globally. Increasing number of studies have shown that miRNAs can be used as prognostic markers for cancers. This study made use of the data available in the Cancer Genome Atlas in order to statistically analyze reported expression levels of miRNAs in samples from bladder urothelial carcinoma patients. Clinical features from a total of 399 patients and the expression data for 1,581 kinds of miRNA were included in the study. Single factor Cox regression analysis was used to identify miRNAs related to survival times for the patients. Then, through multifactors Cox regression we sorted out the independent prognostic miRNAs for the carcinoma. According to our results, 19 miRNAs were closely related to the survival times of patients with bladder urothelial carcinoma, and 3 miRNAs including hsa-mir-518b (p=0.02), hsa-mir-192 (p=0.04) and hsa-mir-7705 (p=0.04) should be useful as independent prognostic factors in patients. In addition, the survival time of those expressing high levels of hsa-mir-7705 and hsa-mir-192 was less than the survival time of those with low expression levels. However, there were no obvious differences in the survival times between high and low expressors of hsa‑mir‑518b. According to our results, hsa-mir-7705, hsa-mir-192 and hsa‑mir-518b can be applied as independent prognostic markers for bladder urothelial carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Hu Y, Cheng C, Hong Z and Shi Z: Independent prognostic miRNAs for bladder urothelial carcinoma. Oncol Lett 14: 3001-3005, 2017.
APA
Hu, Y., Cheng, C., Hong, Z., & Shi, Z. (2017). Independent prognostic miRNAs for bladder urothelial carcinoma. Oncology Letters, 14, 3001-3005. https://doi.org/10.3892/ol.2017.6471
MLA
Hu, Y., Cheng, C., Hong, Z., Shi, Z."Independent prognostic miRNAs for bladder urothelial carcinoma". Oncology Letters 14.3 (2017): 3001-3005.
Chicago
Hu, Y., Cheng, C., Hong, Z., Shi, Z."Independent prognostic miRNAs for bladder urothelial carcinoma". Oncology Letters 14, no. 3 (2017): 3001-3005. https://doi.org/10.3892/ol.2017.6471
Copy and paste a formatted citation
x
Spandidos Publications style
Hu Y, Cheng C, Hong Z and Shi Z: Independent prognostic miRNAs for bladder urothelial carcinoma. Oncol Lett 14: 3001-3005, 2017.
APA
Hu, Y., Cheng, C., Hong, Z., & Shi, Z. (2017). Independent prognostic miRNAs for bladder urothelial carcinoma. Oncology Letters, 14, 3001-3005. https://doi.org/10.3892/ol.2017.6471
MLA
Hu, Y., Cheng, C., Hong, Z., Shi, Z."Independent prognostic miRNAs for bladder urothelial carcinoma". Oncology Letters 14.3 (2017): 3001-3005.
Chicago
Hu, Y., Cheng, C., Hong, Z., Shi, Z."Independent prognostic miRNAs for bladder urothelial carcinoma". Oncology Letters 14, no. 3 (2017): 3001-3005. https://doi.org/10.3892/ol.2017.6471
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