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Case Report Open Access

BRAFV600E mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review

  • Authors:
    • Wanjia Xing
    • Xiaohong Liu
    • Qingqing He
    • Zongjing Zhang
    • Zhaoshun Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, General Hospital of Jinan Military Command, Jinan, Shandong 250031, P.R. China, Department of Pathology, General Hospital of Jinan Military Command, Jinan, Shandong 250031, P.R. China, Department of Thyroid and Breast Surgery, General Hospital of Jinan Military Command, Jinan, Shandong 250031, P.R. China
    Copyright: © Xing et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2903-2911
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    Published online on: June 28, 2017
       https://doi.org/10.3892/ol.2017.6486
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Abstract

Resistance to thyroid hormone (RTH) is a rare autosomal hereditary disorder characterized by increased serum thyroid hormone (TH) levels with unsuppressed or increased thyrotropin concentration. It remains unknown whether the coexistence of RTH with papillary thyroid carcinoma (PTC) and Hashimoto thyroiditis (HT) is incidental or whether it possesses a genetic or pathophysiological association. In the present study, a case of RTH with PTC and HT in an 11‑year‑old Chinese patient was examined and the clinical presentation of RTH with PTC was discussed. In addition, the possible associations between RTH, PTC and HT were determined. HT was confirmed in the patient using an autoimmune assay and thyroid ultrasound. RTH was diagnosed on the basis of clinical manifestations, laboratory information and gene analysis, and PTC was diagnosed according to histological results. Results of BRAFV600E mutation analysis were positive. A literature review of 14 cases of RTH with PTC was included for comparison. The present case report indicates an association of RTH with PTC and HT coexistence in the patient. Close follow‑up, histological evaluation and BRAFV600E mutation detection should be performed in each RTH case with HT, since a persistent increase in TSH may be a risk factor for the development of thyroid neoplasm.
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Copy and paste a formatted citation
Spandidos Publications style
Xing W, Liu X, He Q, Zhang Z and Jiang Z: BRAFV600E mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review. Oncol Lett 14: 2903-2911, 2017.
APA
Xing, W., Liu, X., He, Q., Zhang, Z., & Jiang, Z. (2017). BRAFV600E mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review. Oncology Letters, 14, 2903-2911. https://doi.org/10.3892/ol.2017.6486
MLA
Xing, W., Liu, X., He, Q., Zhang, Z., Jiang, Z."BRAFV600E mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review". Oncology Letters 14.3 (2017): 2903-2911.
Chicago
Xing, W., Liu, X., He, Q., Zhang, Z., Jiang, Z."BRAFV600E mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review". Oncology Letters 14, no. 3 (2017): 2903-2911. https://doi.org/10.3892/ol.2017.6486
Copy and paste a formatted citation
x
Spandidos Publications style
Xing W, Liu X, He Q, Zhang Z and Jiang Z: BRAFV600E mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review. Oncol Lett 14: 2903-2911, 2017.
APA
Xing, W., Liu, X., He, Q., Zhang, Z., & Jiang, Z. (2017). BRAFV600E mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review. Oncology Letters, 14, 2903-2911. https://doi.org/10.3892/ol.2017.6486
MLA
Xing, W., Liu, X., He, Q., Zhang, Z., Jiang, Z."BRAFV600E mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review". Oncology Letters 14.3 (2017): 2903-2911.
Chicago
Xing, W., Liu, X., He, Q., Zhang, Z., Jiang, Z."BRAFV600E mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review". Oncology Letters 14, no. 3 (2017): 2903-2911. https://doi.org/10.3892/ol.2017.6486
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