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Article Open Access

Long non‑coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway

Retraction in: /10.3892/ol.2024.14686
  • Authors:
    • Han Bao
    • Chun‑Guang Guo
    • Peng‑Cheng Qiu
    • Xin‑Lei Zhang
    • Qi Dong
    • Yu‑Kun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy Administration and Drug Information, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Second Hepatobiliary Surgery, The First People's Hospital of Xianyang City, Shaanxi 712000, P.R. China, Department of Nano Fusion Technology, Pusan University, Miryang, Kyungnam 609‑735, Republic of Korea
    Copyright: © Bao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2831-2837
    |
    Published online on: June 30, 2017
       https://doi.org/10.3892/ol.2017.6492
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Abstract

Long non‑coding RNAs (lncRNAs) serve an important role in numerous human diseases, including cancer. Abnormal expression of lncRNAs has been associated with a number of tumor types; however, the underlying mechanisms through which lncRNA functions have yet to be elucidated. The present study primarily focuses on insulin‑like growth factor 2 antisense 1 (Igf2as), a lncRNA reported to be differentially expressed in hepatocellular carcinoma (HCC). Reverse transcription‑quantitative polymerase chain reaction analysis was used to determine the level of Igf2as in HCC cells and tissues. Flow cytometry was used to determine the level of cell apoptosis following Igf2as suppression and western blot analysis was used to identify altered protein expression levels. The results demonstrated that Igf2as was upregulated in HCC cells and tissues, and that the inhibition of Igf2as using a targeted small interfering RNA (si‑Igf2as), significantly decreased cell proliferation and increased apoptosis. Western blot analysis identified that the extracellular signal‑regulated kinase/mitogen‑activated protein kinase (ERK/MAPK) signaling pathway was inhibited in cells transfected with si‑Igf2as. In addition, cell migration was markedly reduced by the knockdown of Igf2as. These results suggest that lncRNA Igf2as may control hepatocellular progression primarily through the regulation of the ERK/MAPK signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Bao H, Guo CG, Qiu PC, Zhang XL, Dong Q and Wang YK: Long non‑coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway Retraction in /10.3892/ol.2024.14686. Oncol Lett 14: 2831-2837, 2017.
APA
Bao, H., Guo, C., Qiu, P., Zhang, X., Dong, Q., & Wang, Y. (2017). Long non‑coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway Retraction in /10.3892/ol.2024.14686. Oncology Letters, 14, 2831-2837. https://doi.org/10.3892/ol.2017.6492
MLA
Bao, H., Guo, C., Qiu, P., Zhang, X., Dong, Q., Wang, Y."Long non‑coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway Retraction in /10.3892/ol.2024.14686". Oncology Letters 14.3 (2017): 2831-2837.
Chicago
Bao, H., Guo, C., Qiu, P., Zhang, X., Dong, Q., Wang, Y."Long non‑coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway Retraction in /10.3892/ol.2024.14686". Oncology Letters 14, no. 3 (2017): 2831-2837. https://doi.org/10.3892/ol.2017.6492
Copy and paste a formatted citation
x
Spandidos Publications style
Bao H, Guo CG, Qiu PC, Zhang XL, Dong Q and Wang YK: Long non‑coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway Retraction in /10.3892/ol.2024.14686. Oncol Lett 14: 2831-2837, 2017.
APA
Bao, H., Guo, C., Qiu, P., Zhang, X., Dong, Q., & Wang, Y. (2017). Long non‑coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway Retraction in /10.3892/ol.2024.14686. Oncology Letters, 14, 2831-2837. https://doi.org/10.3892/ol.2017.6492
MLA
Bao, H., Guo, C., Qiu, P., Zhang, X., Dong, Q., Wang, Y."Long non‑coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway Retraction in /10.3892/ol.2024.14686". Oncology Letters 14.3 (2017): 2831-2837.
Chicago
Bao, H., Guo, C., Qiu, P., Zhang, X., Dong, Q., Wang, Y."Long non‑coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway Retraction in /10.3892/ol.2024.14686". Oncology Letters 14, no. 3 (2017): 2831-2837. https://doi.org/10.3892/ol.2017.6492
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