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MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats

  • Authors:
    • Bo Ning
    • Geng Guo
    • Hong Liu
    • Lei Ning
    • Bao‑Liang Sun
    • Zhen Li
    • Shuo Wang
    • Zheng‑Wen Lv
    • Cun‑Dong Fan
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong 510220, P.R. China, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China, Department of Scientific Research, Taian Central Hospital, Taian, Shandong 271000, P.R. China, Department of Medical Records, Affiliated Hospital of Taishan Medical University, Taian, Shandong 271000, P.R. China, Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong 271000, P.R. China, Department of Neurosurgery, Taian Central Hospital, Taian, Shandong 271000, P.R. China
    Copyright: © Ning et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2940-2946
    |
    Published online on: June 30, 2017
       https://doi.org/10.3892/ol.2017.6496
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Abstract

MSK (mitogen‑ and stress‑activated protein kinase) proteins are a family of mitogen‑activated protein kinases. MSKs represent a novel type of pro‑survival genes, potentially enhancing the phosphorylation of Bcl2‑associated agonist of cell death. However, MSK's function and expression are poorly understood in the central nervous system. In the present study, a subarachnoid hemorrhage (SAH) model was established in SD rats and the expression of MSK1 in the brain subsequent to experimental SAH was investigated. In response to SAH, MSK1 mRNA and protein levels gradually declined, reaching the lowest point at 3 days, and increased thereafter. The expression of active caspase‑3 was negatively correlated with MSK1 level. Colocalization and correlating changes in expression of MSK1 and active caspase‑3 at neurons and astrocytes indicated that MSK1 downregulation may contribute to SAH‑induced apoptosis, validating that MSK1 may be involved in the pathophysiology of the brain cortex subsequent to SAH.
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Copy and paste a formatted citation
Spandidos Publications style
Ning B, Guo G, Liu H, Ning L, Sun BL, Li Z, Wang S, Lv ZW and Fan CD: MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats. Oncol Lett 14: 2940-2946, 2017.
APA
Ning, B., Guo, G., Liu, H., Ning, L., Sun, B., Li, Z. ... Fan, C. (2017). MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats. Oncology Letters, 14, 2940-2946. https://doi.org/10.3892/ol.2017.6496
MLA
Ning, B., Guo, G., Liu, H., Ning, L., Sun, B., Li, Z., Wang, S., Lv, Z., Fan, C."MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats". Oncology Letters 14.3 (2017): 2940-2946.
Chicago
Ning, B., Guo, G., Liu, H., Ning, L., Sun, B., Li, Z., Wang, S., Lv, Z., Fan, C."MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats". Oncology Letters 14, no. 3 (2017): 2940-2946. https://doi.org/10.3892/ol.2017.6496
Copy and paste a formatted citation
x
Spandidos Publications style
Ning B, Guo G, Liu H, Ning L, Sun BL, Li Z, Wang S, Lv ZW and Fan CD: MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats. Oncol Lett 14: 2940-2946, 2017.
APA
Ning, B., Guo, G., Liu, H., Ning, L., Sun, B., Li, Z. ... Fan, C. (2017). MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats. Oncology Letters, 14, 2940-2946. https://doi.org/10.3892/ol.2017.6496
MLA
Ning, B., Guo, G., Liu, H., Ning, L., Sun, B., Li, Z., Wang, S., Lv, Z., Fan, C."MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats". Oncology Letters 14.3 (2017): 2940-2946.
Chicago
Ning, B., Guo, G., Liu, H., Ning, L., Sun, B., Li, Z., Wang, S., Lv, Z., Fan, C."MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats". Oncology Letters 14, no. 3 (2017): 2940-2946. https://doi.org/10.3892/ol.2017.6496
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