Open Access

MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats

  • Authors:
    • Bo Ning
    • Geng Guo
    • Hong Liu
    • Lei Ning
    • Bao‑Liang Sun
    • Zhen Li
    • Shuo Wang
    • Zheng‑Wen Lv
    • Cun‑Dong Fan
  • View Affiliations

  • Published online on: June 30, 2017     https://doi.org/10.3892/ol.2017.6496
  • Pages: 2940-2946
  • Copyright: © Ning et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MSK (mitogen‑ and stress‑activated protein kinase) proteins are a family of mitogen‑activated protein kinases. MSKs represent a novel type of pro‑survival genes, potentially enhancing the phosphorylation of Bcl2‑associated agonist of cell death. However, MSK's function and expression are poorly understood in the central nervous system. In the present study, a subarachnoid hemorrhage (SAH) model was established in SD rats and the expression of MSK1 in the brain subsequent to experimental SAH was investigated. In response to SAH, MSK1 mRNA and protein levels gradually declined, reaching the lowest point at 3 days, and increased thereafter. The expression of active caspase‑3 was negatively correlated with MSK1 level. Colocalization and correlating changes in expression of MSK1 and active caspase‑3 at neurons and astrocytes indicated that MSK1 downregulation may contribute to SAH‑induced apoptosis, validating that MSK1 may be involved in the pathophysiology of the brain cortex subsequent to SAH.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ning B, Guo G, Liu H, Ning L, Sun BL, Li Z, Wang S, Lv ZW and Fan CD: MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats. Oncol Lett 14: 2940-2946, 2017.
APA
Ning, B., Guo, G., Liu, H., Ning, L., Sun, B., Li, Z. ... Fan, C. (2017). MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats. Oncology Letters, 14, 2940-2946. https://doi.org/10.3892/ol.2017.6496
MLA
Ning, B., Guo, G., Liu, H., Ning, L., Sun, B., Li, Z., Wang, S., Lv, Z., Fan, C."MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats". Oncology Letters 14.3 (2017): 2940-2946.
Chicago
Ning, B., Guo, G., Liu, H., Ning, L., Sun, B., Li, Z., Wang, S., Lv, Z., Fan, C."MSK1 downregulation is associated with neuronal and astrocytic apoptosis following subarachnoid hemorrhage in rats". Oncology Letters 14, no. 3 (2017): 2940-2946. https://doi.org/10.3892/ol.2017.6496