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Article Open Access

Overexpression of dendritic cell‑specific intercellular adhesion molecule‑3‑grabbing nonintegrin‑related protein in cervical cancer and correlation with squamous cell carcinoma antigen

  • Authors:
    • Xiangdong Wang
    • Yangmei Jiang
    • Menglang Yuan
    • Chunlin Chen
    • Keyong Wang
    • Qianshi Zhang
    • Yunfei Zuo
    • Shuangyi Ren
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Department of Clinical Laboratory, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, Dalian, Liaoning 116044, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2813-2821
    |
    Published online on: June 30, 2017
       https://doi.org/10.3892/ol.2017.6508
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Abstract

Dendritic cell‑specific intercellular adhesion molecule‑3‑grabbing nonintegrin‑related protein (DC‑SIGNR) is a type II transmembrane protein that has been reported to bind to various pathogens and participate in immunoregulation and tumorigenesis. However, further research is required to investigate whether the level of DC‑SIGNR and cervical cancer are associated. The present study aimed to explore the clinical diagnostic significance of DC‑SIGNR in cervical cancer. Immunohistochemical staining of DC‑SIGNR was performed in samples from 25 patients with early stage cervical cancer, 14 patients with cervical intraepithelial neoplasia (CIN) and cervical polyp samples from 15 individuals. DC‑SIGNR expression in cervical cancer tissue was significantly higher compared with that in CIN and cervical polyp tissue (P=0.0184 and P=0.0236, respectively). However, there was no significant difference in DC‑SIGNR expression between CIN and cervical polyp tissue (P=0.8103). Additionally, the serum DC‑SIGNR levels in 84 cervical cancer patients and 69 healthy female individuals were measured using an ELISA. Serum (s)DC‑SIGNR levels were significantly higher in cervical cancer patients compared with healthy female individuals (P<0.0001). A sDC‑SIGNR level of 93.7 ng/ml was revealed by receiver operating characteristic curve analysis to predict the presence of cervical cancer with 69.57% sensitivity and 66.67% specificity (area under the curve, 0.6989; P<0.0001). Levels of sDC‑SIGNR in cervical cancer patients were also correlated with serum levels of squamous cell carcinoma antigen (r=0.2583; P=0.0348). The results of the present study demonstrate that DC‑SIGNR is overexpressed in cervical cancer tissue, and suggest that DC‑SIGNR could serve as a biomarker for the early diagnosis of cervical cancer. Nevertheless, further studies are required to demonstrate what role DC‑SIGNR serves in cervical cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Jiang Y, Yuan M, Chen C, Wang K, Zhang Q, Zuo Y and Ren S: Overexpression of dendritic cell‑specific intercellular adhesion molecule‑3‑grabbing nonintegrin‑related protein in cervical cancer and correlation with squamous cell carcinoma antigen. Oncol Lett 14: 2813-2821, 2017.
APA
Wang, X., Jiang, Y., Yuan, M., Chen, C., Wang, K., Zhang, Q. ... Ren, S. (2017). Overexpression of dendritic cell‑specific intercellular adhesion molecule‑3‑grabbing nonintegrin‑related protein in cervical cancer and correlation with squamous cell carcinoma antigen. Oncology Letters, 14, 2813-2821. https://doi.org/10.3892/ol.2017.6508
MLA
Wang, X., Jiang, Y., Yuan, M., Chen, C., Wang, K., Zhang, Q., Zuo, Y., Ren, S."Overexpression of dendritic cell‑specific intercellular adhesion molecule‑3‑grabbing nonintegrin‑related protein in cervical cancer and correlation with squamous cell carcinoma antigen". Oncology Letters 14.3 (2017): 2813-2821.
Chicago
Wang, X., Jiang, Y., Yuan, M., Chen, C., Wang, K., Zhang, Q., Zuo, Y., Ren, S."Overexpression of dendritic cell‑specific intercellular adhesion molecule‑3‑grabbing nonintegrin‑related protein in cervical cancer and correlation with squamous cell carcinoma antigen". Oncology Letters 14, no. 3 (2017): 2813-2821. https://doi.org/10.3892/ol.2017.6508
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Jiang Y, Yuan M, Chen C, Wang K, Zhang Q, Zuo Y and Ren S: Overexpression of dendritic cell‑specific intercellular adhesion molecule‑3‑grabbing nonintegrin‑related protein in cervical cancer and correlation with squamous cell carcinoma antigen. Oncol Lett 14: 2813-2821, 2017.
APA
Wang, X., Jiang, Y., Yuan, M., Chen, C., Wang, K., Zhang, Q. ... Ren, S. (2017). Overexpression of dendritic cell‑specific intercellular adhesion molecule‑3‑grabbing nonintegrin‑related protein in cervical cancer and correlation with squamous cell carcinoma antigen. Oncology Letters, 14, 2813-2821. https://doi.org/10.3892/ol.2017.6508
MLA
Wang, X., Jiang, Y., Yuan, M., Chen, C., Wang, K., Zhang, Q., Zuo, Y., Ren, S."Overexpression of dendritic cell‑specific intercellular adhesion molecule‑3‑grabbing nonintegrin‑related protein in cervical cancer and correlation with squamous cell carcinoma antigen". Oncology Letters 14.3 (2017): 2813-2821.
Chicago
Wang, X., Jiang, Y., Yuan, M., Chen, C., Wang, K., Zhang, Q., Zuo, Y., Ren, S."Overexpression of dendritic cell‑specific intercellular adhesion molecule‑3‑grabbing nonintegrin‑related protein in cervical cancer and correlation with squamous cell carcinoma antigen". Oncology Letters 14, no. 3 (2017): 2813-2821. https://doi.org/10.3892/ol.2017.6508
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