Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2017 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2017 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients

  • Authors:
    • Qinghai Guan
    • Zhiqiang Chen
    • Qiangpu Chen
    • Xuting Zhi
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China, Department of General Surgery, The Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256603, P.R. China
    Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2783-2788
    |
    Published online on: July 5, 2017
       https://doi.org/10.3892/ol.2017.6522
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In this study genotyping of hepatocellular carcinoma (HCC) patients was conducted to detect polymorphisms on the X-ray repair cross-complementing 1 (XRCC1) and xeroderma pigmentosum complementary group D (XPD) genes and analyze the relationship of their presence with the clinical features of the cancer. A total of 172 patients with HCC were selected in Qilu Hospital, Shandong University, from January 2010 to September 2011. All patients underwent resection of HCC and no tumor metastases were found. Peripheral venous blood samples (3-5 ml) were collected from the patients to extract genomic DNA. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and gene sequencing. During the five-year follow-up, the survival of patients with various genotypes of XRCC1 and XPD genes were observed and compared. Logistic regression analysis was used to analyze the association between single nucleotide polymorphisms of XRCC1 and XPD genes and the prognosis of patients with HCC. χ2 tests showed that XRCC1-194, XRCC1-280 and XPD-312 gene polymorphisms were significantly correlated with the number, location and diameter of the tumors (p<0.05). No significant difference was found in the survival curve of patients presenting different genotypes of the XRCC1-194 locus (p>0.05). Nevertheless, a significant difference was found in the survival curve of patients with AA and GG genotypes of the XRCC1-280 locus and in the patients with AA, GA and GG genotypes of the XPD-312 locus (p<0.05). Logistic regression analysis showed that the XRCC1-194 genotype was not an independent risk factor for HCC mortality risk (p>0.05), but XRCC1-280 (OR=1.815, p<0.01) and XPD-312 (OR=1.815, p<0.01) genotypes were independent risk factors for a poor prognosis. Taken together our results point to polymorphisms in XRCC1 and XPD genes as being related to the clinical characteristics of HCC, making them suitable prognostic markers of HCC.
View Figures

Figure 1

Figure 2

View References

1 

Bruix J, Gores GJ and Mazzaferro V: Hepatocellular carcinoma: Clinical frontiers and perspectives. Gut. 63:844–855. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Lee SS, Shin HS, Kim HJ, Lee SJ, Lee HS, Hyun KH, Kim YH, Kwon BW, Han JH, Choi H, et al: Analysis of prognostic factors and 5-year survival rate in patients with hepatocellular carcinoma: A single-center experience. Korean J Hepatol. 18:48–55. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Kew MC: Hepatocellular carcinoma: Epidemiology and risk factors. J Hepatocell Carcinoma. 1:115–125. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Seguí N, Mina LB, Lázaro C, Sanz-Pamplona R, Pons T, Navarro M, Bellido F, López-Doriga A, Valdés-Mas R, Pineda M, et al: Germline mutations in FAN1 cause hereditary colorectal cancer by impairing DNA repair. Gastroenterology. 149:563–566. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Patrono C, Sterpone S, Testa A, Verna L, Palma V, Gentile P and Cozzi R: Polymorphisms in X-ray repair cross-complementing group 1 gene: Haplotypes, breast cancer risk and individual radiosensitivity. Open Med J. 2:25–30. 2015. View Article : Google Scholar

6 

Tamura D, DiGiovanna JJ, Khan SG and Kraemer KH: Living with xeroderma pigmentosum: Comprehensive photoprotection for highly photosensitive patients. Photodermatol Photoimmunol Photomed. 30:146–152. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Wang YX, De Baere T, Idee JM and Ballet S: Transcatheter embolization therapy in liver cancer: An update of clinical evidences. Chin J Cancer Res. 27:96–121. 2015.PubMed/NCBI

8 

Hung HH, Chao Y, Chiou YY, Li CP, Lee RC, Huo TI, Huang YH, Chau GY, Su CW, Yeh YC, et al: A comparison of clinical manifestations and prognoses between patients with hepatocellular carcinoma and Child-Pugh scores of 5 or 6. Medicine (Baltimore). 93:e3482014. View Article : Google Scholar : PubMed/NCBI

9 

Liu F, Wang J, Chang H, Lu J and Li H: Relevance between HLA-DP gene rs2281388 polymorphism and hepatocellular carcinoma risk. Int J Clin Exp Pathol. 8:7431–7435. 2015.PubMed/NCBI

10 

Huang X, Zeng Y, Xing X, Zeng J, Gao Y, Cai Z, Xu B, Liu X, Huang A and Liu J: Quantitative proteomics analysis of early recurrence/metastasis of huge hepatocellular carcinoma following radical resection. Proteome Sci. 12:222014. View Article : Google Scholar : PubMed/NCBI

11 

Petta S, Miele L, Bugianesi E, Cammà C, Rosso C, Boccia S, Cabibi D, Di Marco V, Grimaudo S, Grieco A, et al: Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease. PLoS One. 9:e875232014. View Article : Google Scholar : PubMed/NCBI

12 

Akhdar H, El Shamieh S, Musso O, Désert R, Joumaa W, Guyader D, Aninat C, Corlu A and Morel F: The rs3957357C>T SNP in GSTA1 is associated with a higher risk of occurrence of hepatocellular carcinoma in european individuals. PLoS One. 11:e01675432016. View Article : Google Scholar : PubMed/NCBI

13 

Duxin JP and Walter JC: What is the DNA repair defect underlying Fanconi anemia? Curr Opin Cell Biol. 37:49–60. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Bharati R, Jenkins MA, Lindor NM, Le Marchand L, Gallinger S, Haile RW, Newcomb PA, Hopper JL and Win AK: Does risk of endometrial cancer for women without a germline mutation in a DNA mismatch repair gene depend on family history of endometrial cancer or colorectal cancer? Gynecol Oncol. 133:287–292. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Caldecott KW: DNA single-strand break repair. Exp Cell Res. 329:2–8. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Fahmideh M Adel, Schwartzbaum J, Frumento P and Feychting M: Association between DNA repair gene polymorphisms and risk of glioma: A systematic review and meta-analysis. Neuro Oncol. 16:807–814. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Wang JY and Cai Y: X-ray repair cross-complementing group 1 codon 399 polymorphism and lung cancer risk: An updated meta-analysis. Tumour Biol. 35:411–418. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Li Y, Ma QH, Huang ZY, Li SW, Liu F and Tan S: P0163 X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and cervical cancer risk: A systematic review and meta-analysis. Eur J Cancer. 50:e552014. View Article : Google Scholar

19 

Liu J, Fang H, Chi Z, Wu Z, Wei D, Mo D, Niu K, Balajee AS, Hei TK, Nie L, et al: XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage. Nucleic Acids Res. 43:5476–5488. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Bănescu C, Trifa AP, Demian S, Lazar E Benedek, Dima D, Duicu C and Dobreanu M: Polymorphism of XRCC1, XRCC3, and XPD genes and risk of chronic myeloid leukemia. BioMed Res Int. 2014:2137902014. View Article : Google Scholar : PubMed/NCBI

21 

Li P, Wang YD, Cheng J, Chen JC and Ha MW: Association between polymorphisms of BAG-1 and XPD and chemotherapy sensitivity in advanced non-small-cell lung cancer patients treated with vinorelbine combined cisplatin regimen. Tumour Biol. 36:9465–9473. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Guan Q, Chen Z, Chen Q and Zhi X: XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients. Oncol Lett 14: 2783-2788, 2017.
APA
Guan, Q., Chen, Z., Chen, Q., & Zhi, X. (2017). XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients. Oncology Letters, 14, 2783-2788. https://doi.org/10.3892/ol.2017.6522
MLA
Guan, Q., Chen, Z., Chen, Q., Zhi, X."XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients". Oncology Letters 14.3 (2017): 2783-2788.
Chicago
Guan, Q., Chen, Z., Chen, Q., Zhi, X."XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients". Oncology Letters 14, no. 3 (2017): 2783-2788. https://doi.org/10.3892/ol.2017.6522
Copy and paste a formatted citation
x
Spandidos Publications style
Guan Q, Chen Z, Chen Q and Zhi X: XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients. Oncol Lett 14: 2783-2788, 2017.
APA
Guan, Q., Chen, Z., Chen, Q., & Zhi, X. (2017). XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients. Oncology Letters, 14, 2783-2788. https://doi.org/10.3892/ol.2017.6522
MLA
Guan, Q., Chen, Z., Chen, Q., Zhi, X."XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients". Oncology Letters 14.3 (2017): 2783-2788.
Chicago
Guan, Q., Chen, Z., Chen, Q., Zhi, X."XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients". Oncology Letters 14, no. 3 (2017): 2783-2788. https://doi.org/10.3892/ol.2017.6522
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team