Associations between the expression of MTA1 and VEGF‑C in esophageal squamous cell carcinoma with lymph angiogenesis and lymph node metastasis

  • Authors:
    • Jianping Liu
    • Juan Xia
    • Yongheng Zhang
    • Maoyong Fu
    • Sheng Gong
    • Yulong Guo
  • View Affiliations

  • Published online on: July 7, 2017     https://doi.org/10.3892/ol.2017.6530
  • Pages: 3275-3281
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Abstract

The aim of the present study was to investigate the association between the expression levels of metastasis‑related gene 1 (MTA1) and vascular endothelial growth factor C (VEGF‑C) in esophageal squamous cell carcinoma (ESCC) with lymph angiogenesis and lymph node metastasis. The paraffin‑embedded tissue samples of 107 cases of ESCC and 56 cases of normal esophageal tissues were collected from the Department of Cardiothoracic Surgery, Suining Central Hospital from March 2013 to January 2014. Immunohistochemical assays were performed to detect the expression levels of MTA1, VEGF‑C and D2‑40 in ESCC, and the micro‑lymphatic vessel density (LVD) was evaluated. Their associations with various clinicopathological parameters were also analyzed. The protein expression levels of MTA1 and VEGF‑C in ESCC were significantly higher compared with those in normal esophageal tissues (P<0.05); the high protein expression levels of MTA1 and VEGF‑C in ESCC tissues at various tumor‑node‑metastasis stages exhibited statistically significant differences, as revealed by the Kruskal‑Wallis test (P<0.05). The protein expression levels of MTA1 and VEGF‑C in ESCC exhibited positive correlations (Spearman's ρ, r=0.512; P=0.000); the LVD level in the group with high expression of MTA1 and VEGF‑C was significantly higher compared with in the low expression group (P<0.05). The comparison between MTA1 and VEGF‑C protein expression levels in the group with a high rate of lymph node metastasis demonstrated statistically significant differences when compared with in the low lymph node metastasis group (P<0.05). The expression levels of MTA1 and VEGF‑C in ESCC exhibited a positive correlation in ESCC, which may co‑promote lymph angiogenesis and lymph node metastasis in ESCC; therefore, they may be used as biomarkers for determining the prognosis of ESCC.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu J, Xia J, Zhang Y, Fu M, Gong S and Guo Y: Associations between the expression of MTA1 and VEGF‑C in esophageal squamous cell carcinoma with lymph angiogenesis and lymph node metastasis. Oncol Lett 14: 3275-3281, 2017.
APA
Liu, J., Xia, J., Zhang, Y., Fu, M., Gong, S., & Guo, Y. (2017). Associations between the expression of MTA1 and VEGF‑C in esophageal squamous cell carcinoma with lymph angiogenesis and lymph node metastasis. Oncology Letters, 14, 3275-3281. https://doi.org/10.3892/ol.2017.6530
MLA
Liu, J., Xia, J., Zhang, Y., Fu, M., Gong, S., Guo, Y."Associations between the expression of MTA1 and VEGF‑C in esophageal squamous cell carcinoma with lymph angiogenesis and lymph node metastasis". Oncology Letters 14.3 (2017): 3275-3281.
Chicago
Liu, J., Xia, J., Zhang, Y., Fu, M., Gong, S., Guo, Y."Associations between the expression of MTA1 and VEGF‑C in esophageal squamous cell carcinoma with lymph angiogenesis and lymph node metastasis". Oncology Letters 14, no. 3 (2017): 3275-3281. https://doi.org/10.3892/ol.2017.6530