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Article

β‑transducin repeat‑containing E3 ubiquitin protein ligase inhibits migration, invasion and proliferation of glioma cells

  • Authors:
    • Jun Liang
    • Wei‑Feng Wang
    • Shao Xie
    • Xian‑Li Zhang
    • Wei‑Feng Qi
    • Xiu‑Ping Zhou
    • Jin‑Xia Hu
    • Qiong Shi
    • Ru‑Tong Yu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China, Laboratory of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China
  • Pages: 3131-3135
    |
    Published online on: July 7, 2017
       https://doi.org/10.3892/ol.2017.6533
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Abstract

β‑transducin repeat‑containing E3 ubiquitin protein ligase (β‑TrCP) serves as the substrate recognition subunit for the Skp1‑Cullin1‑F‑box protein E3 ubiquitin ligase, which recognizes the double phosphorylated DSG (X)2+nS destruction motif in various substrates that are essential for numerous aspects of tumorigenesis and regulates several important signaling pathways. However, the biological significance of β‑TrCP in glioma progression remains largely unknown. A previous study by the authors demonstrated that the levels of β‑TrCP protein expression in brain glioma tissues were significantly lower compared with non‑tumorous tissues and that higher grades of gliomas exhibited lower levels of β‑TrCP expression in comparison with lower glioma grades. In addition, low β‑TrCP expression was associated with poor prognosis in patients with glioma. Subsequently, the present study aimed to investigate the effect of β‑TrCP on migratory, invasive and proliferative abilities of glioma cells. β‑TrCP plasmids were transfected into cultured U251 and U87 glioma cells, and changes in migration, invasion and proliferation were analyzed using wound healing, Transwell and EdU assays. It was identified that the overexpression of β‑TrCP inhibited migration, invasion and proliferation in glioma cells. In summary, these results indicate that β‑TrCP may serve a protective role against the progression of glioma by suppressing cell migration, invasion and proliferation. The potential mechanism of β‑TrCP I glioma cells requires additional investigation.
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Copy and paste a formatted citation
Spandidos Publications style
Liang J, Wang WF, Xie S, Zhang XL, Qi WF, Zhou XP, Hu JX, Shi Q and Yu RT: β‑transducin repeat‑containing E3 ubiquitin protein ligase inhibits migration, invasion and proliferation of glioma cells. Oncol Lett 14: 3131-3135, 2017.
APA
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X. ... Yu, R. (2017). β‑transducin repeat‑containing E3 ubiquitin protein ligase inhibits migration, invasion and proliferation of glioma cells. Oncology Letters, 14, 3131-3135. https://doi.org/10.3892/ol.2017.6533
MLA
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X., Hu, J., Shi, Q., Yu, R."β‑transducin repeat‑containing E3 ubiquitin protein ligase inhibits migration, invasion and proliferation of glioma cells". Oncology Letters 14.3 (2017): 3131-3135.
Chicago
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X., Hu, J., Shi, Q., Yu, R."β‑transducin repeat‑containing E3 ubiquitin protein ligase inhibits migration, invasion and proliferation of glioma cells". Oncology Letters 14, no. 3 (2017): 3131-3135. https://doi.org/10.3892/ol.2017.6533
Copy and paste a formatted citation
x
Spandidos Publications style
Liang J, Wang WF, Xie S, Zhang XL, Qi WF, Zhou XP, Hu JX, Shi Q and Yu RT: β‑transducin repeat‑containing E3 ubiquitin protein ligase inhibits migration, invasion and proliferation of glioma cells. Oncol Lett 14: 3131-3135, 2017.
APA
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X. ... Yu, R. (2017). β‑transducin repeat‑containing E3 ubiquitin protein ligase inhibits migration, invasion and proliferation of glioma cells. Oncology Letters, 14, 3131-3135. https://doi.org/10.3892/ol.2017.6533
MLA
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X., Hu, J., Shi, Q., Yu, R."β‑transducin repeat‑containing E3 ubiquitin protein ligase inhibits migration, invasion and proliferation of glioma cells". Oncology Letters 14.3 (2017): 3131-3135.
Chicago
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X., Hu, J., Shi, Q., Yu, R."β‑transducin repeat‑containing E3 ubiquitin protein ligase inhibits migration, invasion and proliferation of glioma cells". Oncology Letters 14, no. 3 (2017): 3131-3135. https://doi.org/10.3892/ol.2017.6533
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