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Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients

  • Authors:
    • Hongtao Wei
    • Xiaotong Yu
    • Xiaowei Xue
    • Hui Liu
    • Menglong Wang
    • Yingying Li
    • Xuejiang Wang
    • Huiguo Ding
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Beijing Friendship Hospital, Capital Medical University, Beijing 100069, P.R. China, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, P.R. China, Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China, Department of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2749-2756
    |
    Published online on: July 8, 2017
       https://doi.org/10.3892/ol.2017.6545
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Abstract

Urotensin II and the associated urotensin II receptor (UTR) are important in the carcinogenesis of hepatocellular carcinoma (HCC). However, the clinical significance of UTR remains to be elucidated. The aim of the present study was to investigate if UTR exhibits the potential to act as a biomarker to predict the prognosis of HCC patients. The effects of UTR on motility and invasion of HCC cells were additionally investigated. UTR expression levels were determined by immunohistochemistry, in 83 HCC patients that previously underwent curative liver resection. The association between UTR levels and clinicopathological data were analyzed. In vitro, the expressions of UTR in QSG‑7701, BEL‑7402 and MHCC‑97H cell lines were determined via western blotting. Small interfering (si)RNA was used to downregulate UTR in BEL‑7402 and MHCC‑97H cell lines, and the effects of UTR on tumor cell motility were tested by Transwell assay. UTR expression was associated with tumor number, size, histology and tumor node metastasis/Barcelona Clinic Liver Cancer HCC stage. UTR expression levels were additionally associated with recurrence‑free and overall survival in HCC patients by Kaplan‑Meier curve analysis (P<0.0001). In vitro, UTR expression levels were increased in BEL‑7402 and MHCC‑97H cell lines, compared with QSG‑7701 (P<0.05). siRNA‑mediated silencing of the UTR gene significantly inhibited cell motility in BEL‑7402 and MHCC‑97H cells. The results indicated that UTR may be regarded as a novel biomarker to predict outcomes following radical liver resection and as a potential therapeutic target to inhibit invasion and metastasis of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Wei H, Yu X, Xue X, Liu H, Wang M, Li Y, Wang X and Ding H: Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients. Oncol Lett 14: 2749-2756, 2017.
APA
Wei, H., Yu, X., Xue, X., Liu, H., Wang, M., Li, Y. ... Ding, H. (2017). Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients. Oncology Letters, 14, 2749-2756. https://doi.org/10.3892/ol.2017.6545
MLA
Wei, H., Yu, X., Xue, X., Liu, H., Wang, M., Li, Y., Wang, X., Ding, H."Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients". Oncology Letters 14.3 (2017): 2749-2756.
Chicago
Wei, H., Yu, X., Xue, X., Liu, H., Wang, M., Li, Y., Wang, X., Ding, H."Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients". Oncology Letters 14, no. 3 (2017): 2749-2756. https://doi.org/10.3892/ol.2017.6545
Copy and paste a formatted citation
x
Spandidos Publications style
Wei H, Yu X, Xue X, Liu H, Wang M, Li Y, Wang X and Ding H: Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients. Oncol Lett 14: 2749-2756, 2017.
APA
Wei, H., Yu, X., Xue, X., Liu, H., Wang, M., Li, Y. ... Ding, H. (2017). Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients. Oncology Letters, 14, 2749-2756. https://doi.org/10.3892/ol.2017.6545
MLA
Wei, H., Yu, X., Xue, X., Liu, H., Wang, M., Li, Y., Wang, X., Ding, H."Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients". Oncology Letters 14.3 (2017): 2749-2756.
Chicago
Wei, H., Yu, X., Xue, X., Liu, H., Wang, M., Li, Y., Wang, X., Ding, H."Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients". Oncology Letters 14, no. 3 (2017): 2749-2756. https://doi.org/10.3892/ol.2017.6545
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