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Review Open Access

Associations of tumor suppressor SPARCL1 with cancer progression and prognosis (Review)

  • Authors:
    • Ting Li
    • Xia Liu
    • Antai Yang
    • Wenjie Fu
    • Fuqiang Yin
    • Xiaoyun Zeng
  • View Affiliations / Copyright

    Affiliations: Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Centre for Translational Medicine, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Key Laboratory of High‑Incidence‑Tumor Prevention and Treatment, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2603-2610
    |
    Published online on: July 8, 2017
       https://doi.org/10.3892/ol.2017.6546
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Abstract

SPARC‑like protein 1 (SPARCL1), a member of the family of secreted proteins which is acidic and rich in cysteine, is a potential tumor suppressor gene in most types of tumor. A systemic review and bioinformatics analysis was carried out to determine the associations between SPARCL1 and tumor progression and clinical factors. Downregulation of SPARCL1, thought to be regulated by epigenetic modifications including DNA methylation, serves important functions in tumor progression and development, with its regulatory functions on cell viability, migration, invasion, cell adhesion and drug resistance. Downregulation of SPARCL1 was markedly associated with a poor overall survival rate of patients with one of ≥7 solid tumors and predicted increased mortality in patients with one of ≥4 distinct tumor types. The present review indicated that SPARCL1 may be a therapeutic target for cancer treatment and a biomarker to determine prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Li T, Liu X, Yang A, Fu W, Yin F and Zeng X: Associations of tumor suppressor SPARCL1 with cancer progression and prognosis (Review). Oncol Lett 14: 2603-2610, 2017.
APA
Li, T., Liu, X., Yang, A., Fu, W., Yin, F., & Zeng, X. (2017). Associations of tumor suppressor SPARCL1 with cancer progression and prognosis (Review). Oncology Letters, 14, 2603-2610. https://doi.org/10.3892/ol.2017.6546
MLA
Li, T., Liu, X., Yang, A., Fu, W., Yin, F., Zeng, X."Associations of tumor suppressor SPARCL1 with cancer progression and prognosis (Review)". Oncology Letters 14.3 (2017): 2603-2610.
Chicago
Li, T., Liu, X., Yang, A., Fu, W., Yin, F., Zeng, X."Associations of tumor suppressor SPARCL1 with cancer progression and prognosis (Review)". Oncology Letters 14, no. 3 (2017): 2603-2610. https://doi.org/10.3892/ol.2017.6546
Copy and paste a formatted citation
x
Spandidos Publications style
Li T, Liu X, Yang A, Fu W, Yin F and Zeng X: Associations of tumor suppressor SPARCL1 with cancer progression and prognosis (Review). Oncol Lett 14: 2603-2610, 2017.
APA
Li, T., Liu, X., Yang, A., Fu, W., Yin, F., & Zeng, X. (2017). Associations of tumor suppressor SPARCL1 with cancer progression and prognosis (Review). Oncology Letters, 14, 2603-2610. https://doi.org/10.3892/ol.2017.6546
MLA
Li, T., Liu, X., Yang, A., Fu, W., Yin, F., Zeng, X."Associations of tumor suppressor SPARCL1 with cancer progression and prognosis (Review)". Oncology Letters 14.3 (2017): 2603-2610.
Chicago
Li, T., Liu, X., Yang, A., Fu, W., Yin, F., Zeng, X."Associations of tumor suppressor SPARCL1 with cancer progression and prognosis (Review)". Oncology Letters 14, no. 3 (2017): 2603-2610. https://doi.org/10.3892/ol.2017.6546
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