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Case Report Open Access

Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report

  • Authors:
    • Kiminobu Sato
    • Jun Akiba
    • Ken Nakamura
    • Hideyuki Abe
    • Akihiko Kawahara
    • Takeichiro Aso
    • Hirohito Umeno
    • Hiroshi Harada
    • Hirohisa Yano
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan, Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830‑0011, Japan, Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan, Department of Diagnostic Pathology, Seichokai Fuchu Hospital, Izumi, Osaka 594‑0076, Japan
    Copyright: © Sato et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2970-2974
    |
    Published online on: July 8, 2017
       https://doi.org/10.3892/ol.2017.6550
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Abstract

Among tumors of the major salivary glands, tumors in the sublingual gland are rare. Although mucoepidermoid carcinoma (MEC) represents a histological type of salivary gland tumor, it is occasionally difficult to diagnose due to its histological variation. The present study reports a case of MEC harboring a mastermind‑like transcriptional coactivator 2 (MAML2) gene translocation in the sublingual gland. A 76‑year‑old Japanese woman with a mass in the left submandibular region was referred to Kurume University Hospital (Kurume, Japan). Computed tomography scans revealed that the tumor was predominantly located in the sublingual gland, and tumor resection was performed. Histologically, the tumor was composed of cells that exhibited low‑grade nuclear atypia and clear and/or granular eosinophilic cytoplasm, and that were proliferating in solid patterns. Periodic acid‑Schiff and alcian blue staining revealed a small number of mucinous cells in the tumor. Immunohistochemically, the tumor cells were positive for p40 and p63. Fluorescence in situ hybridization (FISH) analysis revealed a MAML2 gene split. The definitive pathological diagnosis was low‑grade MEC, as the case lacked any factors indicative of high‑grade malignancy. To the best of our knowledge, this is the first report of MEC in the sublingual gland with MAML2 gene translocation confirmed by FISH.
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Copy and paste a formatted citation
Spandidos Publications style
Sato K, Akiba J, Nakamura K, Abe H, Kawahara A, Aso T, Umeno H, Harada H and Yano H: Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report. Oncol Lett 14: 2970-2974, 2017.
APA
Sato, K., Akiba, J., Nakamura, K., Abe, H., Kawahara, A., Aso, T. ... Yano, H. (2017). Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report. Oncology Letters, 14, 2970-2974. https://doi.org/10.3892/ol.2017.6550
MLA
Sato, K., Akiba, J., Nakamura, K., Abe, H., Kawahara, A., Aso, T., Umeno, H., Harada, H., Yano, H."Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report". Oncology Letters 14.3 (2017): 2970-2974.
Chicago
Sato, K., Akiba, J., Nakamura, K., Abe, H., Kawahara, A., Aso, T., Umeno, H., Harada, H., Yano, H."Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report". Oncology Letters 14, no. 3 (2017): 2970-2974. https://doi.org/10.3892/ol.2017.6550
Copy and paste a formatted citation
x
Spandidos Publications style
Sato K, Akiba J, Nakamura K, Abe H, Kawahara A, Aso T, Umeno H, Harada H and Yano H: Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report. Oncol Lett 14: 2970-2974, 2017.
APA
Sato, K., Akiba, J., Nakamura, K., Abe, H., Kawahara, A., Aso, T. ... Yano, H. (2017). Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report. Oncology Letters, 14, 2970-2974. https://doi.org/10.3892/ol.2017.6550
MLA
Sato, K., Akiba, J., Nakamura, K., Abe, H., Kawahara, A., Aso, T., Umeno, H., Harada, H., Yano, H."Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report". Oncology Letters 14.3 (2017): 2970-2974.
Chicago
Sato, K., Akiba, J., Nakamura, K., Abe, H., Kawahara, A., Aso, T., Umeno, H., Harada, H., Yano, H."Mucoepidermoid carcinoma of the sublingual gland harboring a translocation of the MAML2 gene: A case report". Oncology Letters 14, no. 3 (2017): 2970-2974. https://doi.org/10.3892/ol.2017.6550
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