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Article

Upregulation of miR‑520b promotes ovarian cancer growth

  • Authors:
    • Rui Guan
    • Shengyun Cai
    • Mingjuan Sun
    • Mingjuan Xu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai 200433, P.R. China
  • Pages: 3155-3161
    |
    Published online on: July 8, 2017
       https://doi.org/10.3892/ol.2017.6552
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Abstract

Ovarian cancer is the most common gynecological malignant cancer in female genitalia. Dysregulation or dysfunction of microRNAs (miRs) contribute to cancer development. The role of miR‑520b in ovarian cancer remains unclear. The present study investigated the role of miR‑520b in ovarian cancer and determined that the expression levels of miR‑520b in ovarian cancer tissues and cell lines were upregulated. By contrast, reverse transcription-quantitative polymerase chain reaction and immunohistochemistry revealed that the mRNA and protein expression levels of ring finger protein 216 (RNF216) were downregulated in ovarian cancer, indicating that there was a negative correlation between miR‑520b and RNF216. In miR-520b-knockdown cells, downregulation of miR‑520b reduced cell proliferation, while upregulation of miR‑520b promoted cell proliferation. In addition, RNF216 was predicted by TargetScanHuman and was observed to be targeted by miR‑520b. In conclusion, the present data indicated that high expression of miR‑520b in ovarian cancer promoted cell growth via RNF216.
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Copy and paste a formatted citation
Spandidos Publications style
Guan R, Cai S, Sun M and Xu M: Upregulation of miR‑520b promotes ovarian cancer growth. Oncol Lett 14: 3155-3161, 2017.
APA
Guan, R., Cai, S., Sun, M., & Xu, M. (2017). Upregulation of miR‑520b promotes ovarian cancer growth. Oncology Letters, 14, 3155-3161. https://doi.org/10.3892/ol.2017.6552
MLA
Guan, R., Cai, S., Sun, M., Xu, M."Upregulation of miR‑520b promotes ovarian cancer growth". Oncology Letters 14.3 (2017): 3155-3161.
Chicago
Guan, R., Cai, S., Sun, M., Xu, M."Upregulation of miR‑520b promotes ovarian cancer growth". Oncology Letters 14, no. 3 (2017): 3155-3161. https://doi.org/10.3892/ol.2017.6552
Copy and paste a formatted citation
x
Spandidos Publications style
Guan R, Cai S, Sun M and Xu M: Upregulation of miR‑520b promotes ovarian cancer growth. Oncol Lett 14: 3155-3161, 2017.
APA
Guan, R., Cai, S., Sun, M., & Xu, M. (2017). Upregulation of miR‑520b promotes ovarian cancer growth. Oncology Letters, 14, 3155-3161. https://doi.org/10.3892/ol.2017.6552
MLA
Guan, R., Cai, S., Sun, M., Xu, M."Upregulation of miR‑520b promotes ovarian cancer growth". Oncology Letters 14.3 (2017): 3155-3161.
Chicago
Guan, R., Cai, S., Sun, M., Xu, M."Upregulation of miR‑520b promotes ovarian cancer growth". Oncology Letters 14, no. 3 (2017): 3155-3161. https://doi.org/10.3892/ol.2017.6552
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