Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2017 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2017 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma

  • Authors:
    • Xiaodong Huo
    • Bin Huo
    • Huixing Wang
    • Hongdian Zhang
    • Zhao Ma
    • Mingjian Yang
    • Haitao Wang
    • Zhentao Yu
  • View Affiliations / Copyright

    Affiliations: Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, P.R. China, Department of Oncology, Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China, Pain Management Center, Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China
    Copyright: © Huo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2683-2690
    |
    Published online on: July 8, 2017
       https://doi.org/10.3892/ol.2017.6559
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Zinc finger E‑box‑binding homeobox 2 (ZEB2) has been reported to mediate epithelial‑mesenchymal transition (EMT) and disease progression in several cancer types. However, the expression of ZEB2 in esophageal squamous cell carcinoma (OSCC) and its association with prognosis remains unclear. In the present study, a tissue microarray and immunohistochemistry were used to investigate ZEB2 and epithelial (E‑)cadherin expression in OSCC tissues (n=218) and peritumoral esophageal tissues (POT; n=60). There was a significantly increased incidence of positive ZEB2 expression in OSCC tissues compared with the expression in POTs (P<0.012). By contrast, the incidence of positive E‑cadherin expression in OSCC tissues was significantly decreased compared with the expression in POTs (P<0.004). ZEB2 expression in OSCC was associated with a number of clinicopathological factors, and it was also an independent predictive factor for shorter overall survival time (P<0.001). Overall, ZEB2 may promote OSCC metastasis and is a potential prognostic marker for malignancy.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Xu Y, Yu X, Chen Q and Mao W: Neoadjuvant versus adjuvant treatment: Which one is better for resectable esophageal squamous cell carcinoma? World J Surg Oncol. 10:1732012. View Article : Google Scholar : PubMed/NCBI

2 

Zhao P, Dai M, Chen W and Li N: Cancer trends in China. Jpn J Clin Oncol. 40:281–285. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, et al: Identification of genomic alterations in esophageal squamous cell cancer. Nature. 509:91–95. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Pennathur A, Gibson MK, Jobe BA and Luketich JD: Oesophageal carcinoma. Lancet. 381:400–412. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Rice TW, Rusch VW, Apperson-Hansen C, Allen MS, Chen LQ, Hunter JG, Kesler KA, Law S, Lerut TE, Reed CE, et al: Worldwide esophageal cancer collaboration. Dis Esophagus. 22:1–8. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Shapiro IM, Cheng AW, Flytzanis NC, Balsamo M, Condeelis JS, Oktay MH, Burge CB and Gertler FB: An EMT-driven alternative splicing program occurs in human Breast Cancer and Modulates Cellular Phenotype. PLoS Genet. 7:e10022182011. View Article : Google Scholar : PubMed/NCBI

8 

Polyak K and Weinberg RA: Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits. Nat Rev Cancer. 9:265–273. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Peinado H, Olmeda D and Cano A: Snail, Zeb and bHLH factors in tumor progression: An alliance against the epithelial phenotype? Nat Rev Cancer. 7:415–428. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Niwa Y, Yamada S, Koike M, Kanda M, Fujii T, Nakayama G, Sugimoto H, Nomoto S, Fujiwara M and Kodera Y: Epithelial to mesenchymal transition correlates with tumor budding and predicts prognosis in esophagealsquamous cell carcinoma. J Surg Oncol. 110:764–769. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Jin H, Morohashi S, Sato F, Kudo Y, Akasaka H, Tsutsumi S, Ogasawara H, Miyamoto K, Wajima N, Kawasaki H, et al: Vimentin expression of esophageal squamous cell carcinoma and its aggressive potential for lymph node metastasis. Biomed Res. 31:105–112. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Wang F, Li XK, Xu HY, Shan ZZ, Wang T, Yang ZC, He W, Wang LX and Fan QX: N-cadherin participated in invasion and metastasis of human esophageal squamous cell carcinoma via taking part in the formation of vasculogenic mimicry. Med Oncol. 32:4802015. View Article : Google Scholar : PubMed/NCBI

13 

Dong H, Xie L, Tang C, Chen S, Liu Q, Zhang Q, Zheng W, Zheng Z and Zhang H: Snail1 correlates with patient outcomes in E-cadherin-preserved gastroesophageal junction adenocarcinoma. Clin Transl Oncol. 16:783–791. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Forghanifard MM, Moaven O, Farshchian M, Montazer M, Raeisossadati R, Abdollahi A, Moghbeli M, Nejadsattari T, Parivar K and Abbaszadegan MR: Expression analysis elucidates the roles of MAML1 and Twist1 in esophageal squamous cell carcinoma aggressiveness and metastasis. Ann Surg Oncol. 19:743–749. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Gong T, Xue Z, Tang S, Zheng X, Xu G, Gao L, Zhao G, Hong L, Tang G, Zhang H, et al: Nuclear expression of Twist promotes lymphatic metastasis in esophageal squamous cell carcinoma. Cancer Biol Ther. 13:606–613. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Lee KW, Kim JH, Han S, Sung CO, Do IG, Ko YH, Um SH and Kim SH: Twist1 is an independent prognostic factor of esophageal squamous cell carcinoma and associated with its epithelial-mesenchymal transition. Ann Surg Oncol. 19:326–335. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Song X, Han P, Liu J, Wang Y, Li D, He J, Gong J, Li M, Tu W, Yan W, et al: Up-regulation of SPOCK1 induces epithelial-mesenchymal transition and promotes migration and invasion inesophageal squamous cell carcinoma. J Mol Histol. 46:347–356. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Wang N, Liu F, Cao F, Jia Y, Wang J, Ma W, Tan B, Wang K, Song Q and Cheng Y: RACK1 predicts poor prognosis and regulates progression of esophageal squamous cell carcinoma through its epithelial-mesenchymal transition. Cancer Biol Ther. 16:528–540. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Beck TN, Chikwem AJ, Solanki NR and Golemis EA: Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer. Physiol Genomics. 46:699–724. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Postigo AA, Depp JL, Taylor JJ and Kroll KL: Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J. 22:2453–2462. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Hegarty SV, Sullivan AM and O'Keeffe GW: Zeb2: A multifunctional regulator of nervous system development. Prog Neurobiol. 132:81–95. 2015. View Article : Google Scholar : PubMed/NCBI

22 

National Comprehensive Cancer Network. (NCCN) Clinical Practice Guidelines in Oncology. Esophageal and Esophagogastric Junction Cancers. version 1. 2015.https://www.nccn.org/professionals/physician_gls/f_guidelines.asp#esophageal

23 

Hao XP, Pretlow TG, Rao JS and Pretlow TP: Beta-catenin expression is altered in human colonic aberrant crypt foci. Cancer Res. 61:8085–8088. 2001.PubMed/NCBI

24 

Jolly MK, Boareto M, Huang B, Jia D, Lu M, Ben-Jacob E, Onuchic JN and Levine H: Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis. Front Oncol. 5:1552015. View Article : Google Scholar : PubMed/NCBI

25 

Du HF, Ou LP, Yang X, Song XD, Fan YR, Tan B, Luo CL and Wu XH: A new PKCα/β/TBX3/E-cadherin pathway is involved in PLCε-regulated invasion and migration in human bladder cancer cells. Cell Signal. 26:580–593. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Wu W, Tian Y, Wan H, Ma J, Song Y, Wang Y and Zhang L: Expression of β-catenin and E- and N-cadherin in human brainstem gliomas and clinicopathological correlations. Int J Neurosci. 123:318–323. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Koay MH, Crook M and Stewart CJ: Cyclin D1, E-cadherin and beta-catenin expression in FIGO Stage IA cervical squamous carcinoma: Diagnostic value and evidence for epithelial-mesenchymal transition. Histopathology. 61:1125–1133. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Carneiro P, Figueiredo J, Bordeira-Carriço R, Fernandes MS, Carvalho J, Oliveira C and Seruca R: Therapeutic targets associated to E-cadherin dysfunction in gastric cancer. Expert Opin Ther Targets. 17:1187–1201. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Liu TA, Jan YJ, Ko BS, Liang SM, Chen SC, Wang J, Hsu C, Wu YM and Liou JY: 14-3-3ε overexpression contributes to epithelial-mesenchymal transition of hepatocellular carcinoma. PLoS One. 8:e579682013. View Article : Google Scholar : PubMed/NCBI

30 

Yoshida R, Morita M, Shoji F, Nakashima Y, Miura N, Yoshinaga K, Koga T, Tokunaga E, Saeki H, Oki E, et al: Clinical Significance of SIP1 and E-cadherin in Patients with Esophageal Squamous Cell Carcinoma. Ann Surg Oncol. 22:2608–2614. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Muir AB, Dods K, Noah Y, Toltzis S, Chandramouleeswaran PM, Lee A, Benitez A, Bedenbaugh A, Falk GW, Wells RG, et al: Esophageal epithelial cells acquire functional characteristics of activated myofibroblasts after undergoing an epithelial to mesenchymal transition. Exp Cell Res. 330:102–110. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Fang WK, Liao LD, Zeng FM, Zhang PX, Wu JY, Shen J, Xu LY and Li EM: Desmocollin-2 affects the adhesive strength and cytoskeletal arrangement in esophageal squamous cell carcinoma cells. Mol Med Rep. 10:2358–2364. 2014.PubMed/NCBI

33 

Wong TS, Gao W and Chan JY: Transcription regulation of E-cadherin by zinc finger E-box binding homeobox proteins in solid tumors. Biomed Res Int. 2014:9215642014. View Article : Google Scholar : PubMed/NCBI

34 

Bhardwaj M, Sen S, Sharma A, Kashyap S, Chosdol K, Pushker N, Bajaj MS and Bakhshi S: ZEB2/SIP1 as novel prognostic indicator in eyelid sebaceous gland carcinoma. Hum Pathol. 46:1437–1442. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Prislei S, Martinelli E, Zannoni GF, Petrillo M, Filippetti F, Mariani M, Mozzetti S, Raspaglio G, Scambia G and Ferlini C: Role and prognostic significance of the epithelial-mesenchymal transition factor ZEB2 in ovarian cancer. Oncotarget. 6:18966–18979. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Galván JA, Zlobec I, Wartenberg M, Lugli A, Gloor B, Perren A and Karamitopoulou E: Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumor and stromal cells influences tumor-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer. Br J Cancer. 112:1944–1950. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Miyoshi A, Kitajima Y, Sumi K, Sato K, Hagiwara A, Koga Y and Miyazaki K: Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer. 90:1265–1273. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Davalos V, Moutinho C, Villanueva A, Boque R, Silva P, Carneiro F and Esteller M: Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene. 31:2062–2074. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Sun X, Sun Z, Zhu Z, Li C, Zhang J, Xu H and Sun M: Expression of SIP1 is strongly correlated with LDHA and shows a significantly poor outcome in gastric cancer. Tumour Biol. 36:7521–7530. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Jouppila-Mättö A, Mannermaa A, Sironen R, Kosma VM, Soini Y and Pukkila M: SIP1 predicts progression and poor prognosis in pharyngeal squamous cell carcinoma. Histol Histopathol. 30:569–579. 2015.PubMed/NCBI

41 

Kong YH, Syed Zanaruddin SN, Lau SH, Ramanathan A, Kallarakkal TG, Vincent-Chong VK, Wan Mustafa WM, Abraham MT, Abdul Rahman ZA, Zain RB and Cheong SC: Co-Expression of TWIST1 and ZEB2 in oral squamous cell carcinoma is associated with poor Survival. PLoS One. 10:e01340452015. View Article : Google Scholar : PubMed/NCBI

42 

Miura N, Yano T, Shoji F, Kawano D, Takenaka T, Ito K, Morodomi Y, Yoshino I and Maehara Y: Clinicopathological significance of Sip1-associated epithelial mesenchymal transition in non-small cell lung cancer progression. Anticancer Res. 29:4099–4106. 2009.PubMed/NCBI

43 

Mehendiratta M, Solomon MC, Boaz K, Guddattu V and Mohindra A: Clinico-pathological correlation of Ecadherin expression at the invasive tumor front of Indian oral squamous cell carcinomas: An immunohistochemical study. J Oral Maxillofac Pathol. 18:217–222. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Mostaan LV, Khorsandi MT, Sharifian SM, Shandiz FH, Mirashrafi F, Sabzari H, Badiee R, Borghei H and Yazdani N: Correlation between E-cadherin and CD44 adhesion molecules expression and cervical lymph node metastasis in oral tongue SCC: Predictive significance or not. Pathol Res Pract. 207:448–451. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Gamba CO, Campos LC, Negreiros-Lima GL, Maciel-Lima K, Sousa LP, Estrela-Lima A, Ferreira E and Cassali GD: ZEB2 and ZEB1 expression in a spontaneous canine model of invasive micropapillary carcinoma of the mammary gland. Res Vet Sci. 97:554–559. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Fang Y, Wei J, Cao J, Zhao H, Liao B, Qiu S, Wang D, Luo J and Chen W: Protein expression of ZEB2 in renal cell carcinoma and its prognostic significance in patient survival. PLoS One. 8:e625582013. View Article : Google Scholar : PubMed/NCBI

47 

Chu PY, Hu FW, Yu CC, Tsai LL, Yu CH, Wu BC, Chen YW, Huang PI and Lo WL: Epithelial-mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer. Oral Oncol. 49:34–41. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Okugawa Y, Inoue Y, Tanaka K, Kawamura M, Saigusa S, Toiyama Y, Ohi M, Uchida K, Mohri Y and Kusunoki M: Smad interacting protein 1 (SIP1) is associated with peritoneal carcinomatosis in intestinal type gastric cancer. Clin Exp Metastasis. 30:417–429. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Sayan AE, Griffiths TR, Pal R, Browne GJ, Ruddick A, Yagci T, Edwards R, Mayer NJ, Qazi H, Goyal S, et al: SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer. Proc Natl Acad Sci USA. 106:14884–14889. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Maeda G, Chiba T, Okazaki M, Satoh T, Taya Y, Aoba T, Kato K, Kawashiri S and Imai K: Expression of SIP1 in oral squamous cell carcinomas: Implications for E-cadherin expression and tumor progression. Int J Oncol. 27:1535–1541. 2005.PubMed/NCBI

51 

Torlakovic EE, Nielsen S, Vyberg M and Taylor CR: Getting controls under control: The time is now for immunohistochemistry. J Clin Pathol. 68:879–882. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huo X, Huo B, Wang H, Zhang H, Ma Z, Yang M, Wang H and Yu Z: Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma. Oncol Lett 14: 2683-2690, 2017.
APA
Huo, X., Huo, B., Wang, H., Zhang, H., Ma, Z., Yang, M. ... Yu, Z. (2017). Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma. Oncology Letters, 14, 2683-2690. https://doi.org/10.3892/ol.2017.6559
MLA
Huo, X., Huo, B., Wang, H., Zhang, H., Ma, Z., Yang, M., Wang, H., Yu, Z."Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma". Oncology Letters 14.3 (2017): 2683-2690.
Chicago
Huo, X., Huo, B., Wang, H., Zhang, H., Ma, Z., Yang, M., Wang, H., Yu, Z."Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma". Oncology Letters 14, no. 3 (2017): 2683-2690. https://doi.org/10.3892/ol.2017.6559
Copy and paste a formatted citation
x
Spandidos Publications style
Huo X, Huo B, Wang H, Zhang H, Ma Z, Yang M, Wang H and Yu Z: Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma. Oncol Lett 14: 2683-2690, 2017.
APA
Huo, X., Huo, B., Wang, H., Zhang, H., Ma, Z., Yang, M. ... Yu, Z. (2017). Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma. Oncology Letters, 14, 2683-2690. https://doi.org/10.3892/ol.2017.6559
MLA
Huo, X., Huo, B., Wang, H., Zhang, H., Ma, Z., Yang, M., Wang, H., Yu, Z."Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma". Oncology Letters 14.3 (2017): 2683-2690.
Chicago
Huo, X., Huo, B., Wang, H., Zhang, H., Ma, Z., Yang, M., Wang, H., Yu, Z."Prognostic significance of the epithelial‑mesenchymal transition factor zinc finger E‑box‑binding homeobox 2 in esophageal squamous cell carcinoma". Oncology Letters 14, no. 3 (2017): 2683-2690. https://doi.org/10.3892/ol.2017.6559
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team