Low‑risk population among patients with tumor‑node‑metastasis stage III/IV oral squamous cell carcinoma

Ikeda,Tohru; Seki,Sachiko; Fujiwara,Mutsunori; Matsuura,Masaaki; Ozaki‑Honda,Yuu; Fujita,Shuichi; Ikeda,Hisazumi; Umeda,Masahiro; Asahina,Izumi

doi:10.3892/ol.2017.6575

Low‑risk population among patients with tumor‑node‑metastasis stage III/IV oral squamous cell carcinoma

Authors:
- Tohru Ikeda
- Sachiko Seki
- Mutsunori Fujiwara
- Masaaki Matsuura
- Yuu Ozaki‑Honda
- Shuichi Fujita
- Hisazumi Ikeda
- Masahiro Umeda
- Izumi Asahina
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Affiliations: Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113‑8549, Japan, Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852‑8588, Japan, Department of Clinical Pathology, Japanese Red Cross Medical Center, Tokyo 150‑8935, Japan, Graduate School of Public Health, Teikyo University, Tokyo 173‑8605, Japan, Department of Clinical Physiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852‑8588, Japan, Sasebo General Hospital, Sasebo 857‑8511, Japan, Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852‑8588, Japan, Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852‑8588, Japan
Published online on: July 15, 2017 https://doi.org/10.3892/ol.2017.6575
Pages: 3711-3716

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Abstract

A novel system auxiliary to the Union for International Cancer Control classification may allow the prognosis of patients with malignant tumors at similar stages to be predicted, as currently this is challenging. The present study generated a novel system to predict populations at low risk among patients with stage III/IV oral squamous cell carcinoma (OSCC). A total of 41 patients who were diagnosed at stages III/IV OSCC and underwent surgical tumor resection were analyzed. Band‑like or follicular lymphocyte infiltration, intraepithelial micro‑abscess formation and natural killer (NK) cell infiltration were histopathologically evaluated. Cox's proportional hazards regression model was used to identify prognostic factors, and a set of factors was selected from a combination of those prognostic factors to create a logic covariate model. A logic regression analysis for 41 patients with OSCC revealed that the presence of intraepithelial micro‑abscesses and a lower density of NK cells were significantly associated with a favorable prognosis among patients with stage III/IV OSCC. These results suggested that the host innate immune responses, including neutrophil and NK cell infiltrations, are useful for prognostic prediction in patients with advanced malignant tumors.

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