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Article Open Access

Expression of family with sequence similarity 172 member A and nucleotide‑binding protein 1 is associated with the poor prognosis of colorectal carcinoma

Corrigendum in: /10.3892/ol.2023.13821
  • Authors:
    • Wenjun Liu
    • Shuang Wang
    • Kai Qian
    • Jinqian Zhang
    • Zhi Zhang
    • Hao Liu
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Laboratory Medicine, The Second People's Hospital of Guangdong, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3587-3593
    |
    Published online on: July 15, 2017
       https://doi.org/10.3892/ol.2017.6585
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Abstract

In our previous studies, a functionally unknown gene, family with sequence similarity 172, member A (FAM172A), was identified. High levels of FAM172A suppressed the cell cycle process, arresting HepG2 cells in G1/S and inhibiting cell proliferation. The present study aimed to confirm the expression levels of FAM172A and nucleotide‑binding protein 1 (NUBP1) in colorectal cancer (CRC) tissues and normal colorectal tissues. The impact of FAM172A and NUBP1 on the prognosis of patients with CRC was also analyzed. Immunohistochemical staining for FAM172A and NUBP1 was performed on 180 cancerous tissues and 60 normal paraffin‑embedded tissues from patients with CRC. In total, 85 and 83% of 180 patients revealed positive expression of FAM172A and NUBP1, respectively. FAM172A expression level was associated with Tumor‑Node‑Metastasis (TNM) staging (P<0.001), the levels of serum carcinoembryonic antigen (CEA; P=0.023) and carbohydrate antigen 19‑9 (CA19‑9; P=0.016), lymph node involvement (P=0.004), tissue type (P=0.016), Dukes' staging (P<0.001) and NUBP1 (P=0.026). Furthermore, the expression level of NUBP1 was also markedly associated with the levels of serum CEA (P=0.006) and CA19‑9 (P=0.001), TNM staging (P<0.001), lymph node involvement (P=0.005), histological typing (P=0.024) and Dukes' stage (P<0.001). Results of the univariate analysis demonstrated that there was a negative correlation between the expression level of FAM172A and overall survival (OS) and relapse‑free survival (RFS) (P=0.013 and P=0.012, respectively), and there was also a negative correlation between NUBP1 expression level and OS and RFS (P<0.001 and P<0.001, respectively). With regards to OS and RFS, multivariate analysis revealed that expression levels of FAM172A and NUBP1 and tumor stage may be independent prognostic factors Thus, the present study suggested that FAM172A and NUBP1 may be prognostic makers for CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Wang S, Qian K, Zhang J, Zhang Z and Liu H: Expression of family with sequence similarity 172 member A and nucleotide‑binding protein 1 is associated with the poor prognosis of colorectal carcinoma Corrigendum in /10.3892/ol.2023.13821. Oncol Lett 14: 3587-3593, 2017.
APA
Liu, W., Wang, S., Qian, K., Zhang, J., Zhang, Z., & Liu, H. (2017). Expression of family with sequence similarity 172 member A and nucleotide‑binding protein 1 is associated with the poor prognosis of colorectal carcinoma Corrigendum in /10.3892/ol.2023.13821. Oncology Letters, 14, 3587-3593. https://doi.org/10.3892/ol.2017.6585
MLA
Liu, W., Wang, S., Qian, K., Zhang, J., Zhang, Z., Liu, H."Expression of family with sequence similarity 172 member A and nucleotide‑binding protein 1 is associated with the poor prognosis of colorectal carcinoma Corrigendum in /10.3892/ol.2023.13821". Oncology Letters 14.3 (2017): 3587-3593.
Chicago
Liu, W., Wang, S., Qian, K., Zhang, J., Zhang, Z., Liu, H."Expression of family with sequence similarity 172 member A and nucleotide‑binding protein 1 is associated with the poor prognosis of colorectal carcinoma Corrigendum in /10.3892/ol.2023.13821". Oncology Letters 14, no. 3 (2017): 3587-3593. https://doi.org/10.3892/ol.2017.6585
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Wang S, Qian K, Zhang J, Zhang Z and Liu H: Expression of family with sequence similarity 172 member A and nucleotide‑binding protein 1 is associated with the poor prognosis of colorectal carcinoma Corrigendum in /10.3892/ol.2023.13821. Oncol Lett 14: 3587-3593, 2017.
APA
Liu, W., Wang, S., Qian, K., Zhang, J., Zhang, Z., & Liu, H. (2017). Expression of family with sequence similarity 172 member A and nucleotide‑binding protein 1 is associated with the poor prognosis of colorectal carcinoma Corrigendum in /10.3892/ol.2023.13821. Oncology Letters, 14, 3587-3593. https://doi.org/10.3892/ol.2017.6585
MLA
Liu, W., Wang, S., Qian, K., Zhang, J., Zhang, Z., Liu, H."Expression of family with sequence similarity 172 member A and nucleotide‑binding protein 1 is associated with the poor prognosis of colorectal carcinoma Corrigendum in /10.3892/ol.2023.13821". Oncology Letters 14.3 (2017): 3587-3593.
Chicago
Liu, W., Wang, S., Qian, K., Zhang, J., Zhang, Z., Liu, H."Expression of family with sequence similarity 172 member A and nucleotide‑binding protein 1 is associated with the poor prognosis of colorectal carcinoma Corrigendum in /10.3892/ol.2023.13821". Oncology Letters 14, no. 3 (2017): 3587-3593. https://doi.org/10.3892/ol.2017.6585
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