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Article

Upfront high‑dose chemotherapy combined with autologous stem cell transplantation: Potential survival benefit for patients with high‑risk diffuse large B‑cell lymphoma

  • Authors:
    • Aya Nakaya
    • Shinya Fujita
    • Atsushi Satake
    • Takahisa Nakanishi
    • Yoshiko Azuma
    • Yukie Tsubokura
    • Masaaki Hotta
    • Hideaki Yoshimura
    • Kazuyoshi Ishii
    • Tomoki Ito
    • Shosaku Nomura
  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan
  • Pages: 3803-3808
    |
    Published online on: July 15, 2017
       https://doi.org/10.3892/ol.2017.6589
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Abstract

In patients with diffuse large B‑cell lymphoma (DLBCL) classified as high‑intermediate risk or high risk using the International Prognosis Index, the efficacy of high‑dose chemotherapy combined with upfront autologous stem cell transplantation (HDT/ASCT) remains controversial in the rituximab era. In the present study, 27 patients who had been treated with HDT/ASCT in an upfront setting were retrospectively analyzed, and compared with 77 patients with similar characteristics who had received conventional chemotherapy without HDT/ASCT (the non‑upfront setting). The 3‑year overall survival and progression‑free survival rates in the upfront setting were 88.5% (P=0.0134 vs. non‑upfront setting) and 68.4% (P=0.113 vs. non‑upfront setting), respectively; in the non‑upfront setting, the 3‑year overall survival and progression‑free survival rates were 60.8 and 50.6%, respectively. In conclusion, the results indicate that upfront HDT/ASCT in patients with high‑risk DLBCL is feasible and may improve the outcome of these patients. It may be beneficial for patients to undergo HDT/ASCT as an early treatment, prior to the development of therapy resistance.
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Copy and paste a formatted citation
Spandidos Publications style
Nakaya A, Fujita S, Satake A, Nakanishi T, Azuma Y, Tsubokura Y, Hotta M, Yoshimura H, Ishii K, Ito T, Ito T, et al: Upfront high‑dose chemotherapy combined with autologous stem cell transplantation: Potential survival benefit for patients with high‑risk diffuse large B‑cell lymphoma. Oncol Lett 14: 3803-3808, 2017.
APA
Nakaya, A., Fujita, S., Satake, A., Nakanishi, T., Azuma, Y., Tsubokura, Y. ... Nomura, S. (2017). Upfront high‑dose chemotherapy combined with autologous stem cell transplantation: Potential survival benefit for patients with high‑risk diffuse large B‑cell lymphoma. Oncology Letters, 14, 3803-3808. https://doi.org/10.3892/ol.2017.6589
MLA
Nakaya, A., Fujita, S., Satake, A., Nakanishi, T., Azuma, Y., Tsubokura, Y., Hotta, M., Yoshimura, H., Ishii, K., Ito, T., Nomura, S."Upfront high‑dose chemotherapy combined with autologous stem cell transplantation: Potential survival benefit for patients with high‑risk diffuse large B‑cell lymphoma". Oncology Letters 14.3 (2017): 3803-3808.
Chicago
Nakaya, A., Fujita, S., Satake, A., Nakanishi, T., Azuma, Y., Tsubokura, Y., Hotta, M., Yoshimura, H., Ishii, K., Ito, T., Nomura, S."Upfront high‑dose chemotherapy combined with autologous stem cell transplantation: Potential survival benefit for patients with high‑risk diffuse large B‑cell lymphoma". Oncology Letters 14, no. 3 (2017): 3803-3808. https://doi.org/10.3892/ol.2017.6589
Copy and paste a formatted citation
x
Spandidos Publications style
Nakaya A, Fujita S, Satake A, Nakanishi T, Azuma Y, Tsubokura Y, Hotta M, Yoshimura H, Ishii K, Ito T, Ito T, et al: Upfront high‑dose chemotherapy combined with autologous stem cell transplantation: Potential survival benefit for patients with high‑risk diffuse large B‑cell lymphoma. Oncol Lett 14: 3803-3808, 2017.
APA
Nakaya, A., Fujita, S., Satake, A., Nakanishi, T., Azuma, Y., Tsubokura, Y. ... Nomura, S. (2017). Upfront high‑dose chemotherapy combined with autologous stem cell transplantation: Potential survival benefit for patients with high‑risk diffuse large B‑cell lymphoma. Oncology Letters, 14, 3803-3808. https://doi.org/10.3892/ol.2017.6589
MLA
Nakaya, A., Fujita, S., Satake, A., Nakanishi, T., Azuma, Y., Tsubokura, Y., Hotta, M., Yoshimura, H., Ishii, K., Ito, T., Nomura, S."Upfront high‑dose chemotherapy combined with autologous stem cell transplantation: Potential survival benefit for patients with high‑risk diffuse large B‑cell lymphoma". Oncology Letters 14.3 (2017): 3803-3808.
Chicago
Nakaya, A., Fujita, S., Satake, A., Nakanishi, T., Azuma, Y., Tsubokura, Y., Hotta, M., Yoshimura, H., Ishii, K., Ito, T., Nomura, S."Upfront high‑dose chemotherapy combined with autologous stem cell transplantation: Potential survival benefit for patients with high‑risk diffuse large B‑cell lymphoma". Oncology Letters 14, no. 3 (2017): 3803-3808. https://doi.org/10.3892/ol.2017.6589
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